BIOACTIVE MATERIALS

Xueying An, Hantao Cai, Wenshu Wu, Minyi Cai et al.

Abstract not available. Bibliographic information is searchable.

Haiyan Weng, Longyou Xiao, Ting Li, Hengrui Chang et al.

Abstract not available. Bibliographic information is searchable.

Jiahao Wang, Xiaokang Zhang, Qi Zhang, Jiheng Xiao et al.

Abstract not available. Bibliographic information is searchable.

Alessandra Di Lorenzo, Amr F. Mohamed, Benedetta Isella, Daniel Behme et al.

Abstract not available. Bibliographic information is searchable.

Luojia Chen, Zihao Li, Chao Shen, Si-Ling Chen et al.

The complexity, high recurrence rate, and need for long-term monitoring in dermatophytosis treatment underscore the demand for high-performance antifungal strategies. Here, we present a theranostic wearable hydrogel dressing (LIG⁺ITZ@PCS hydrogel) that integrates laser-induced graphene (LIG) with co-encapsulated itraconazole (ITZ) for synergistic therapy and real-time monito…

Shijie Ma, Zhirui Zhang, Jiabao Hao, Juan Li et al.

The ability to treat Helicobacter pylori (H. pylori) infection and eliminate its associated gastric cancer risk is highly desirable but has proven to be extremely difficult. In this study, pilot proteomic screening of clinical gastric mucosal samples suggested a progressive decline in Sirtuin 1 abundance along the H. pylori-associated pathological cascade. Based on these findin…

Hongwei Shao, Zehua Lei, Wenjie Yang, Jiaqi Zhou et al.

Osteoarthritis (OA) progression is fueled by a self-perpetuating cycle of synovitis and cartilage degradation. Current clinical therapies exhibit suboptimal efficacy, primarily due to the lack of strategies that target the multifactorial pathogenesis of OA. Herein, we developed an injectable thermosensitive hydroxypropyl chitin hydrogel (HPCH) loaded with an optimized concentra…

Changyi Zhou, Rui Wang, Jiasheng Yin, Yue Yu et al.

Poly-lactic acid (PLA) bioresorbable scaffolds provide temporary vascular support but trigger late-stage inflammation during polymer dissolution, frequently driving neointimal hyperplasia before complete dissolution. While acute biomaterial responses are well documented, the innate immune mechanisms dictating chronic vascular remodeling remain poorly defined. We demonstrate tha…

Jialin Liu, Tang Cai, Chengao Du, Jia She et al.

Biodegradable magnesium (Mg) alloys are promising candidates for guided bone regeneration (GBR) owing to their bone-matched elastic modulus and intrinsic bioactivity. However, simultaneously achieving mechanical robustness, degradation control, and multifunctional bioactivity in a single Mg-based membrane remains a major challenge. Herein, a magnesium-strontium/magnesium-silver…

Yang Xiao, Xingyu Gao, Tingting Sun, Jiasheng Jiang et al.

Postoperative wound management remains challenging, owing to the lack of tools for continuous, localized, and quantitative assessment of wound inflammation. To address this limitation, we advance a device-level integration strategy that enables localized multimodal monitoring within a suturable platform. We develop a multifunctional smart suture by engineering a metal-organic f…

Jinsheng Li, Ming Yang, Guowen Duan, Jianhao Huang et al.

Engineering implant topography has emerged as a promising strategy to promote bone regeneration in complex fractures and large bone defects. Among such topographies, TiO₂ nanotubes serve as a model topography and have been shown, within a certain range, to positively regulate osteogenic differentiation through diameter-dependent effects. However, the underlying mechanisms re…

Aoao Wang, Zebin Gui, Li Ruan, Chaofeng Hu et al.

Titanium implants are widely used in orthopedic surgery due to their excellent biocompatibility and mechanical properties. However, their long-term clinical success is often limited by complications such as postoperative infection, chronic inflammation, and inadequate osseointegration. In recent years, hydrogels have been extensively explored for tissue regeneration because of …

Jiaying Zhao, Sijia Hao, Ning Gao, Hao Zhang et al.

The repair of craniofacial bones requires high-quality mineralization. The key regulator involved in the difference in mineralization of craniofacial bones remains unknown. As the main component of the bone, citrate regulates hydroxyapatite crystallization. We found that the regional accumulation of citrate caused differences in mineralization. Transcriptome analysis showed tha…

Yidong Hu, Zheqian Zhang, Pingping Yuan, Gaoyue Yang et al.

Achieving rapid endothelialization to maintain the patency of small-diameter vascular grafts remains a significant clinical challenge. Conventional surface modification strategies provide limited biochemical signals for recruiting circulating endothelial cells and fail to mitigate perivascular scarring and fibrosis. Emerging evidence underscores the critical role of regenerated…

Nan Wu, Xi Luan, Bihe Yuan, Mingyuan Xia et al.

Incomplete resection and rapid postoperative recurrence remain major challenges in glioblastoma (GBM) treatment. Inspired by the self-healing microduct architecture of pine resin, we developed an injectable magnetothermal-responsive hierarchical hydrogel microsphere platform, HGM + Multi(+), for spatiotemporally programmed magnetothermal ablation, anti-angiogenic blockade, and …

He Liu, Chanchan Chen, Mengjie Li, Lari Häkkinen et al.

Persistent infection and unresolved inflammation remain major obstacles to successful vital pulp therapy. Strategies capable of simultaneously controlling bacterial burden and regulating the inflamed pulp microenvironment remain limited. In this study, we investigated the effects of the innate defense regulator peptide IDR-1002 on pulp repair under inflammatory conditions. IDR-…

Yiming Xiang, Ziya Gong, Juying Liu, Yizhou Zhu et al.

Beyond their conventional role as passive transdermal delivery vehicles, microneedle (MN) platforms now function as active bio-interfaces capable of modulating therapeutic responses in both localized and systemic diseases. This review summarizes recent advances in MN technology, focusing on the transition from traditional matrix-controlled delivery to bioactive microneedles. Al…

Chengcheng Luan, Dong Ming, Xiaosong Gu

Traumatic spinal cord injury (TSCI) typically leads to persistent motor and sensory deficits. Interdisciplinary advances have supported preclinical research into tissue engineering approaches for TSCI repair, with the core objective of reconstructing damaged neural tissue and restoring both anatomical integrity and physiological neural function. Many published reviews provide o…

Linbo Zhang, Pandong Lin, Dandan Wang, Xue Wang et al.

Piezoelectric materials offer a promising bioinspired direction for bone regeneration by mimicking the native electromechanical environment of bone. However, existing studies mainly focus on extracellular piezoelectric cues perceived by cell membrane, while whether force–electric signals can be precisely regulated at subcellular functional units governing osteogenesis remains i…

Yi-Wei Chen, Jia-Li Lin, Nai-Sheng Zhai, Shi-Hao Zhou et al.

Steroid-associated osteonecrosis (SON) is characterized by a refractory bone defect microenvironment involving oxidative stress, persistent inflammation, and impaired vascularization, which limits the efficacy of conventional graft materials. Here, we developed a temporally programmable composite hydrogel, GelMA/dECM@MnO 2 -GA, by integrating human induced pluripotent stem cell…