Hydrogel coatings for titanium implants: From smart stimuli-responsive strategies to multimodal bone regeneration
Source abstract
Abstract
Titanium implants are widely used in orthopedic surgery due to their excellent biocompatibility and mechanical properties. However, their long-term clinical success is often limited by complications such as postoperative infection, chronic inflammation, and inadequate osseointegration. In recent years, hydrogels have been extensively explored for tissue regeneration because of their biological activity and functional versatility. One emerging application is the surface modification of titanium implants, in which hydrogel coatings can be engineered to improve implant adaptability and osseointegration under complex pathological conditions. This review summarizes the classification, fabrication methods, stimuli-responsive features, and emerging bone-regenerative applications of hydrogel coatings on titanium implants. We also discuss the prospects and challenges of functionalized hydrogel coatings for titanium implants in clinical translation. By examining the latest advances in this rapidly evolving research area, the review aims to catalyze innovation in implant-based bone repair and therapeutic applications.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
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References (100+)
Show source-provided references
1. Surface coating of orthopedic implant to enhance the osseointegration and reduction of bacterial colonization: a review10.1186/s40824-022-00269-3 ↗
2. 3D printing metal implants in orthopedic surgery: methods, applications and future prospects
3. Bone biomaterials and interactions with stem cells10.1038/boneres.2017.59 ↗
4. Engineering precise interconnected porosity in β-tricalcium phosphate (β-TCP) matrices by means of top-down digital light processing10.3390/biomedicines12040736 ↗
5. Incorporating zinc ion into titanium surface promotes osteogenesis and osteointegration in implantation early phase10.1007/s10856-023-06751-1 ↗
6. Development of novel Ti-Mo-Mn alloys for biomedical applications10.1038/s41598-020-62865-4 ↗
7. Toward a better regeneration through implant-mediated immunomodulation: harnessing the immune responses10.1002/advs.202100446 ↗
8. Advanced surface engineering of titanium materials for biomedical applications: from static modification to dynamic responsive regulation
9. Self-assembled anchor layers/polysaccharide coatings on titanium surfaces: a study of functionalization and stability10.3762/bjnano.6.63 ↗
10. Enzymatically-degradable hydrogel coatings on titanium for bacterial infection inhibition and enhanced soft tissue compatibility via a self-adaptive strategy
11. A surface-engineered multifunctional TiO2 based nano-layer simultaneously elevates the corrosion resistance, osteoconductivity and antimicrobial property of a magnesium alloy10.1016/j.actbio.2019.09.008 ↗
12. Plasma proteins at the interface of dental implants modulate osteoblasts focal adhesions expression and cytoskeleton organization10.3390/nano9101407 ↗
13. Multifunctional and transformable ‘clickable’ hydrogel coatings on titanium surfaces: from protein immobilization to cellular attachment10.3390/polym12061211 ↗
14. Nanostructured titanium implant surface facilitating osseointegration from protein adsorption to osteogenesis: the example of TiO2 NTAs10.2147/IJN.S362720 ↗
15. The synergy of topographical micropatterning and Ta|TaCu bilayered thin film on titanium implants enables dual-functions of enhanced osteogenesis and anti-infection
16. Recent advances in anti-inflammatory material design10.1002/adhm.202001373 ↗
17. Iodine-doped 3D print Ti alloy for antibacterial therapy on orthopedic implants10.1021/acsomega.3c04721 ↗
18. Mesenchymal stromal cells-loaded 3D radially aligned composite scaffold with potentiated paracrine signaling for sequential bone regeneration
19. Spatiotemporal delivery of required facilitators for microenvironment remodeling propels neural regeneration after spinal cord injury10.1002/adma.202503479 ↗
20. Near-field electrospun 3D anisotropic fiber-hydrogel scaffold integrated with photothermal effect for skin wound healing
21. Multifunctional coatings for robotic implanted device10.3390/ijms20205126 ↗
22. Antibacterial hydrogel coating: strategies in surface chemistry10.1016/j.cis.2020.102280 ↗
23. A multifunction hydrogel-coating engineered implant for rescuing biofilm infection and boosting osseointegration by macrophage-related immunomodulation10.1002/adhm.202300722 ↗
24. Construction of pH-responsive hydrogel coatings on titanium surfaces for antibacterial and osteogenic properties10.3389/fchem.2025.1546637 ↗
25. ROS-responsive hydrogel coating modified titanium promotes vascularization and osteointegration of bone defects by orchestrating immunomodulation10.1016/j.biomaterials.2022.121683 ↗
26. Modified titanium implants satisfy the demands of diabetic osseointegration via sequential regulation of macrophages and mesenchymal stem cells10.1002/adhm.202401556 ↗
27. Progress in surface modification of titanium implants by hydrogel coatings10.3390/gels9050423 ↗
28. Hydrogel coatings of implants for pathological bone repair10.1002/adhm.202401296 ↗
29. Growth factor delivery approaches in hydrogels10.1021/bm801103c ↗
30. Overview of natural hydrogels for regenerative medicine applications10.1007/s10856-019-6318-7 ↗
31. Pharmacological functions, synthesis, and delivery progress for collagen as biodrug and biomaterial10.3390/pharmaceutics15051443 ↗
32. Promoted angiogenesis and osteogenesis by dexamethasone-loaded calcium phosphate nanoparticles/collagen composite scaffolds with microgroove networks
33. Novel biomedical applications of crosslinked collagen10.1016/j.tibtech.2018.10.007 ↗
34. Bone formation from porcine dental germ stem cells on surface modified polybutylene succinate scaffolds
35. Collagen- and hyaluronic acid-based hydrogels and their biomedical applications10.1016/j.mser.2021.100641 ↗
36. Synthesis and characterization of a photocleavable collagen-like peptide10.1039/C7OB02198D ↗
37. Enhanced biological response of AVS-functionalized Ti6Al4V alloy through covalent immobilization of collagen10.1038/s41598-018-21685-3 ↗
38. Collagen type I coating stimulates bone regeneration and osteointegration of titanium implants in the osteopenic rat10.1007/s00264-015-2926-0 ↗
39. Biomimetic surfaces coated with covalently immobilized collagen type I: an X-ray photoelectron spectroscopy, atomic force microscopy, micro-CT and histomorphometrical study in rabbits10.3390/ijms20030724 ↗
40. Regulation of macrophage polarization by mineralized collagen coating to accelerate the osteogenic differentiation of mesenchymal stem cells10.1021/acsbiomaterials.1c00834 ↗
41. Type I collagen decorated nanoporous network on titanium implant surface promotes osseointegration through mediating immunomodulation, angiogenesis, and osteogenesis10.1016/j.biomaterials.2022.121684 ↗
42. Dual-functional 3D-printed porous bioactive scaffold enhanced bone repair by promoting osteogenesis and angiogenesis
43. Bioactive hydrogels for bone regeneration
44. Effects of temoporfin-based photodynamic therapy on the in vitro antibacterial activity and biocompatibility of gelatin-hyaluronic acid cross-linked hydrogel membranes10.3390/pharmaceutics14112314 ↗
45. Surface immobilization of gelatin onto TiO2 nanotubes to modulate osteoblast behavior10.1016/j.colsurfb.2017.08.043 ↗
46. Initial bone regeneration around fenestrated implants in beagle dogs using basic fibroblast growth factor-gelatin hydrogel complex with varying biodegradation rates10.1016/j.jpor.2008.08.009 ↗
47. Construction and osteogenic effects of 3D-printed porous titanium alloy loaded with VEGF/BMP-2 shell-core microspheres in a sustained-release system
48. Enhanced bone regeneration of cortical segmental bone defects using porous titanium scaffolds incorporated with colloidal gelatin gels for time- and dose-controlled delivery of dual growth factors10.1089/ten.tea.2013.0181 ↗
49. Research on the osteogenic properties of 3D-printed porous titanium alloy scaffolds loaded with GelMA/PAAM-ZOL composite hydrogels
50. Silk fibroin and silk-based biomaterial derivatives for ideal wound dressings10.1016/j.ijbiomac.2020.08.041 ↗
51. Processing, mechanical properties and bio-applications of silk fibroin-based high-strength hydrogels10.1016/j.actbio.2021.02.018 ↗
52. Non-mulberry silk fibroin influence osteogenesis and osteoblast-macrophage cross talk on titanium based surface10.1038/srep04745 ↗
53. Biomimetic AgNPs@antimicrobial peptide/silk fibroin coating for infection-trigger antibacterial capability and enhanced osseointegration
54. Antibiotics drug release controlling and osteoblast adhesion from titania nanotubes arrays using silk fibroin coating
55. Dual delivery of platelet-derived growth factor and bone morphogenetic factor-6 on titanium surface to enhance the early period of implant osseointegration10.1111/jre.12756 ↗
56. A 3D-printed scaffold composed of Alg/HA/SIS for the treatment of diabetic bone defects
57. Injectable sodium alginate hydrogel loaded with plant polyphenol-functionalized silver nanoparticles for bacteria-infected wound healing10.1016/j.ijbiomac.2023.123691 ↗
58. Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting10.1186/s13036-020-0227-7 ↗
59. Alginate-derived antibacterial and antifungal agents: a review of applications and advancements (2019-2025)
60. Using a degradable three-layer sandwich-type coating to prevent titanium implant infection with the combined efficient bactericidal ability and fast immune remodeling property10.1016/j.actbio.2022.10.033 ↗
61. Long acting anti-infection constructs on titanium10.1016/j.jconrel.2020.06.013 ↗
62. Poly-l-lysine/sodium alginate coating loading nanosilver for improving the antibacterial effect and inducing mineralization of dental implants10.1021/acsomega.0c00986 ↗
63. Ceramic scaffolds enriched with gentamicin loaded poly(lactide-co-glycolide) microparticles for prevention and treatment of bone tissue infections
64. Controlled release of dopamine coatings on titanium bidirectionally regulate osteoclastic and osteogenic response behaviors
65. Chitosan-based scaffolds incorporated with silver nanoparticles for the treatment of infected wounds10.3390/pharmaceutics16030327 ↗
66. Chitin and chitosan from the Norway lobster by-products: antimicrobial and anti-proliferative activities10.1016/j.ijbiomac.2016.02.057 ↗
67. Enhanced antibacterial and wound healing activities of microporous chitosan-Ag/ZnO composite dressing10.1016/j.carbpol.2016.09.051 ↗
68. Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices10.1093/rb/rby013 ↗
69. An improved osseointegration of metal implants by pitavastatin loaded multilayer films with osteogenic and angiogenic properties10.1016/j.biomaterials.2021.121260 ↗
70. Coating polyelectrolyte multilayers loaded with quercetin on titanium surfaces by layer-by-layer assembly technique to improve surface osteogenesis under osteoporotic condition10.1166/jbn.2021.3115 ↗
71. Insulin growth factor binding protein-3 enhances dental implant osseointegration against methylglyoxal-induced bone deterioration in a rat model10.5051/jpis.2101200060 ↗
72. BMP2-loaded titania nanotubes coating with pH-responsive multilayers for bacterial infections inhibition and osteogenic activity improvement10.1016/j.colsurfb.2019.02.014 ↗
73. Applications of chitosan in prevention and treatment strategies of infectious diseases10.3390/pharmaceutics16091201 ↗
74. An enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property
75. Gentamicin-loaded bioactive hydroxyapatite/chitosan composite coating electrodeposited on titanium10.1021/acsbiomaterials.8b00859 ↗
76. Optimized electrophoretic deposition of chitosan/mesoporous glass nanoparticles with gentamicin on titanium implants: enhancing hemocompatibility and antibacterial activity10.1021/acsabm.4c00488 ↗
77. Deposition of catechol-functionalized chitosan and silver nanoparticles on biomedical titanium surfaces for antibacterial application
78. Photo-responsive chitosan/Ag/MoS2 for rapid bacteria-killing10.1016/j.jhazmat.2019.121122 ↗
79. Functional chitosan gel coating enhances antimicrobial properties and osteogenesis of titanium alloy under persistent chronic inflammation
80. Hydrogel-exosome system in tissue engineering: a promising therapeutic strategy
81. Microbial production of hyaluronic acid: current state, challenges, and perspectives10.1186/1475-2859-10-99 ↗
82. Improved new bone formation capacity of hyaluronic acid-bone substitute compound in rat calvarial critical size defect10.1186/s12903-024-04679-8 ↗
83. Effect of high- and low-molecular-weight hyaluronic-acid-functionalized-AZ31 Mg and Ti alloys on proliferation and differentiation of osteoblast cells10.1021/acsbiomaterials.8b00968 ↗
84. Poly(vinyl alcohol) hydrogels: the old and new functional materials10.1155/2021/2225426 ↗
85. Conducting polymer hydrogels based on supramolecular strategies for wearable sensors
86. Harnessing stimuli-responsive biomaterials for advanced biomedical applications10.1002/EXP.20230133 ↗
87. Electrically conductive lignin reinforced PAA/HA scaffolds with enhanced biological activity via polyelectrolyte multilayer coatings for tissue engineering applications10.1038/s41598-025-99440-8 ↗
88. Alginate-Sr/Mg containing bioactive glass scaffolds: the characterization of a new 3D composite for bone tissue engineering10.3390/jfb15070183 ↗
89. Alginate-agarose hydrogels improve the in vitro differentiation of human dental pulp stem cells in chondrocytes. A histological study10.3390/biomedicines9070834 ↗
90. Advances in the development and optimization strategies of the hemostatic biomaterials
91. Collagen-based hydrogels for cartilage regeneration10.1111/os.13884 ↗
92. Au nanozyme-based multifunctional hydrogel for inflammation visible monitoring and treatment
93. A multi-functional double cross-linked chitosan hydrogel with tunable mechanical and antibacterial properties for skin wound dressing10.1016/j.carbpol.2023.121344 ↗
94. Hydrogel-enhanced autologous chondrocyte implantation for cartilage regeneration-an update on preclinical studies10.3390/bioengineering11111164 ↗
95. Nanomaterials-incorporated hydrogels for 3D bioprinting technology10.1186/s40580-023-00402-5 ↗
96. Gelatin methacryloyl hydrogels for musculoskeletal tissue regeneration10.3390/bioengineering9070332 ↗
97. Silk fibroin hydrogels for biomedical applications
98. A digital light processing 3D-printed artificial skin model and full-thickness wound models using silk fibroin bioink10.1016/j.actbio.2023.04.034 ↗
99. Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications10.1186/s40779-023-00448-w ↗
100. Mechanotransducive biomimetic systems for chondrogenic differentiation in vitro10.3390/ijms22189690 ↗