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journal article·2026-07-06Open access

Rapid In Vitro Pathological Diagnosis of Glioma Using Dual‐Color Quantum Dot Probes for Precise Intraoperative Resection

Dongdong Wu, Chenxuan Yang, Yuanbin Wu, Minghang Liu, Yizhi Zhang, Yuang Cai, Yibo Zhang, Jimei Chi, Hengchao Ma, Ding Zhang, Chenqing Liu, Meng Su, Guochen Sun

Advanced Science
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Source abstract

Abstract

ABSTRACT Brain gliomas’ variable growth patterns and locations hinder complete surgical removal, while existing clinical imaging/histological methods fail to guide intraoperative resection. To address this, we developed blue‐green dual‐color probes (perovskite quantum dots conjugated to antibodies) targeting glioma cells and IDH1‐mutant simultaneously. These enable rapid intraoperative in vitro pathological diagnosis, helping surgeons devise resection strategies for personalized precise treatment. Tested on 56 clinical frozen sections, the combined detection using dual probes can be completed within 30 min with 91% accuracy: the glioma‐targeting probe identifies tumor boundaries, while the IDH1‐targeting one distinguishes subtypes for optimized margin delineation. We established a personalized resection strategy guided by these results; the dual‐target probes show great potential to assist neurosurgeons in precise glioma resection.
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Research context

Electronic materials

OpenAlex topics: Quantum Dots Synthesis And Properties · Carbon and Quantum Dots Applications · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Neurosurgery The First Medical Centre Chinese PLA General Hospital Beijing Beijing China

Medical School of Chinese PLA Beijing China

Department of Emergency Medicine, the Seventh Medical Center Chinese PLA General Hospital Beijing China

Nankai University School of Medicine Nankai University Tianjin China

Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing Engineering Research Center of Nanomaterials for Green Printing Technology Beijing National Laboratory for Molecular Sciences (BNLMS) Beijing China

Department of Otorhinolaryngology, Head and Neck Surgery Sixth Medical Center of the Chinese PLA General Hospital Beijing China

Funding

National Key Research and Development Program of China

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