ADVANCED SCIENCE

Ailing Pan, De Yan, Anwu Xu, Hong Du et al.

ABSTRACT Precise interfacial engineering and rational component synergy are critical for high‐performance photocatalysts but remain challenging to achieve. Here, we report a COF/nanocluster hybrid photocatalyst (NZT‐1) constructed by a hydrogen‐bonding‐directed assembly strategy. The catalyst comprises a photoactive TP‐TDS COF (a covalent organic framework built from 2,4,6‐trif…

Anna V. Leopold, Vladislav V. Verkhusha

ABSTRACT Toll‐like receptors (TLRs) are single‐pass transmembrane proteins that initiate innate immune responses through recognition of pathogen‐associated molecular patterns, including lipopolysaccharide, flagellin, and microbial nucleic acids. In mammals, TLRs are expressed in both immune and non‐immune cells, where they activate cytokine expression through the myeloid differ…

Yupeng Wang, Nicolas Raison, Xuyang Zhang, Aijia Yang et al.

ABSTRACT Minimally invasive surgery (MIS) removes direct tactile feedback from surgical procedures, making it challenging for surgeons to manipulate delicate anatomy, such as vasculature and other soft tissue. Existing tactile tools developed for MIS in prior research are either too bulky or have limited sensing coverage, restricting their utility in practical surgical workflow…

Kaiyue Wang, Xueting Huang, Lingxiao Yang, Jin Liu et al.

ABSTRACT Hepatic encephalopathy (HE) is a serious neuropsychiatric complication of acute or chronic liver failure. It occurred in approximately 40% of acute liver failure cases and affected 30%–45% of patients with chronic liver failure or decompensated cirrhosis. Hyperammonemia is widely recognized as a central pathogenic factor in the pathogenesis of HE. Rifaximin (RIF), a no…

Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano et al.

ABSTRACT Therapeutic needs to modulate brain circuits highlight graphene‐based materials (GBMs) as an emerging tool to engineer specific interventions to treat neuro‐diseases. In this context, graphene oxide (GO) nanosheets offer new drug delivery strategies to reach neural cells and signaling networks selectively. To complex and transport neuropeptide Y (NPY), GO was engineere…

Zhennan Tian, Jun Wu, Haifeng Zhao, Yong Yang et al.

ABSTRACT All‐inorganic CsPbI ₃ perovskite holds great promise for high‐performance deep‐red light‐emitting diodes (LEDs), yet its hardly controllable phase transition and crystallization readily induce abundant defects in the resultant thin‐film emitters. The development of alkaline substrate‐assisted CsPbI ₃ modulation has enabled significant performance improvements in …

Jian Pan, Chan Shu, Oscar Tutusaus, Rana Mohtadi

ABSTRACT Metal‐anode batteries promise energy densities beyond conventional Li‐ion. However, despite decades of study and earlier discontinued commercialization efforts, they still lag Li‐ion in efficiency, cycle life, and safety, leaving practical adoption uncertain. Key challenges stem from the metals’ inherent reactivity, incomplete understanding of interphase formation and …

Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz et al.

ABSTRACT With the growing burden of age‐related diseases, understanding and modulating the aging process has become a priority. Transcriptomic aging clocks (TACs) can track biological age but remain limited by platform dependence, tissue specificity, or restricted accessibility. To address this, we developed Pasta, a robust and broadly applicable human TAC, built using a novel …

Jing Huang, Lu Chen, Tiancheng Wu, Yating Li et al.

ABSTRACT The incidence of peripheral precocious puberty (PPP) in females has been rising steadily, emerging as a significant public health concern. However, the paternal developmental origins of PPP remain poorly understood. Using a rat model, we found that paternal preconception caffeine exposure (PPCE) induced PPP‐like phenotypes in female offspring and showed paternal‐line p…

Zhuohao Liu, Gang Li, Kaiying Wang

ABSTRACT Micro‐supercapacitors (MSCs) are emerging as indispensable energy units for integrated microsystems, where miniaturization, rapid power delivery, and long‐term stability must be achieved simultaneously. Despite substantial progress in electrode materials, device architectures, and microfabrication technologies, the field remains largely device‐centric, with advances st…

Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin et al.

ABSTRACT Haploinsufficiency of the histone methyltransferase NSD2 is a major cause of Wolf‐Hirschhorn syndrome (WHS) and the related Rauch‐Steindl syndrome (RAUST), both of which exhibit microcephaly and intellectual disability. However, the precise role of NSD2 in brain development remains unclear. Here, we identify NSD2 as a pivotal epigenetic regulator orchestrating the tran…

Suman Kundu, Tao Shen, Kai Betlem, Murali K. Ghatkesar et al.

ABSTRACT Ultraviolet (UV) imagers are important for a variety of applications, such as quality inspection in the semiconductor industry, forensics and food quality inspection, but are often costly because they require dedicated semiconductor process flows. Here, an imaging chip is introduced that has been fabricated using standard 40 nm complementary metal‐oxide‐semiconductor (…

Kelong Fan, Hui Wei, Xiyun Yan

Abstract not available. Bibliographic information is searchable.

Jongbin Yu, Dosung Lee, Namjung Kim

ABSTRACT Recent advancements in artificial intelligence (AI)–based design strategies have expanded the ability to generate complex mechanical metamaterials across multiple length scales. However, achieving precise control of mechanical properties while preserving structural connectivity remains a major challenge, especially for functionally graded metamaterials with heterogeneo…

Ting‐Han Lin, Yin‐Hsuan Chang, Jia‐Mao Chang, Ciao‐Yun Huang et al.

ABSTRACT The accumulation of microplastic waste has raised growing environmental concerns, motivating the development of sustainable strategies for plastic‐to‐fuel conversion. Here, we report a platinum single‐atom catalyst anchored on distorted graphitic carbon nitride (Pt ₁ /CN) for efficient photocatalytic microplastics photoreforming. Unlike conventional planar g‐C ₃ …

Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan et al.

Abstract not available. Bibliographic information is searchable.

Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay et al.

ABSTRACT Background Amyotrophic lateral sclerosis (ALS) is considered a highly complex, heterogeneous, fatal disease with a high unmet medical need that affects multiple pathophysiological pathways and has no known singular cause. Oxidative stress, however, is implicated as a central player in the progression of ALS and other neurodegenerative diseases. To date, only two FDA‐ap…

Hao Guo, Linheng He, Qinxin Wang, Man Yuan et al.

ABSTRACT Gas sensing technology has significant applications in environmental monitoring, industrial safety, and disease diagnosis. Aerogel has become a key material for building high‐performance gas sensors through engineering design such as heterostructure construction and component compositing, with its high specific surface area, three‐dimensional interconnection network st…

Xiaxia Cui, Yiqing Liu, Xinyi Qiu, Manfei Liu et al.

ABSTRACT We present a photo‐gated corona microfluidics (PGCM) platform for programmable manipulation of diverse microscale objects on open, electrode‐pattern‐free surfaces. In PGCM, near‐infrared laser irradiation locally triggers a reversible solid–liquid phase transition in the paraffin layer, switching the charge‐transport regime from diffusion‐limited to convection‐dominate…

Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer

ABSTRACT Rapid and accurate characterization of antimicrobial resistance is essential for effective patient treatment and outcomes. Infection‐causing microorganisms often harbour multi‐drug resistance, requiring multiple tests for identification. Here, we present a multiplex functional assay using liquid atmospheric pressure (LAP) matrix‐assisted laser desorption/ionization (MA…