Identification and Drug Screening of Single Cells from Human Tumors on Semiconductor Chip for Cancer Precision Medicine (Adv. Sci. 28/2025)

Impedance Sensing Semiconductor Chip for Precision Medicine The cover image demonstrates a system integrating single-cell identification and drug screening on a semiconductor chip. In article number 2503131 by Shuhong Yi, Ping Wang, Yanwei Jia, and co-workers, an integrated circuit and microelectrode array is built on a semiconductor chip for single-cell electric cell-substrate impedance sensing (IC-ECIS) of ultra-weak signals, for distinguishing cancer cells from non-cancerous cells obtained from human tumors. Drug screening was run on the same chip after cell identification for dual evaluation of drug efficacy and toxicity in clinical cancer patients.