Novel Platform for Surface-Mediated Gene Delivery Assisted with Visible-Light Illumination
Source abstract
Abstract
Surface-mediated gene delivery has attracted more and more attentions in biomedical research and applications because of its characteristics of low toxicity and localized delivery. Herein, a novel visible-light-regulated, surface-mediated gene-delivery platform is exhibited, arising from the photoinduced surface-charge accumulation on silicon. Silicon with a pn junction is used and tested subsequently for the behavior of surface-mediated gene delivery under visible-light illumination. It is found that positive-charge accumulation under light illumination changes the surface potential and then facilitates the delivery of gene-loaded carriers. As a result, the gene-expression efficiency shows a significant improvement from 6% to 28% under a 10 min visible-light illumination. Such improvement is ascribed to the increase in surface potential caused by light illumination, which promotes both the release of gene-loaded carriers and the cellular uptake. This work suggests that silicon with photovoltaic effect could offer a new strategy for surface-mediated, gene-delivery-related biomedical research and applications.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanowire Synthesis and Applications · Advanced biosensing and bioanalysis techniques · Quantum Dots Synthesis And Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou 310027, P. R. China
The Affiliated Stomatologic Hospital of Medical College, Zhejiang University, Hangzhou 310003, P. R. China
The First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310003, P. R. China
College of Electrical Engineering, Zhejiang University, Hangzhou 310027, P. R. China
Funding
State Administration of Foreign Experts Affairs · Ministry of Education of the People's Republic of China · National Natural Science Foundation of China
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