journal article·2025-08-27

Fully Triazine-Based Covalent Framework for Antibacterial Phototreatment with High Biosafety

Hu Liu, Ruoyan Miao, Xiaoying Zhao, Xiaolong Du, Lizhen Liu, Wenfeng Li, Zhenhui Ma, Liang Zhang, Jianzheng He, Zhichuan J. Xu

ACS Applied Materials & Interfaces· Volume 17· Issue 34
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Abstract

The application of antibacterial photocatalytic therapy remains a great challenge due to the limitations of photocatalytic efficiency and biosafety of photocatalysts. Herein, we report an organic semiconductor catalyst featuring a unique covalent triazine framework (CTF) structure, which is entirely composed of triazine-based rings. This catalyst exhibits the lowest forbidden bandgap, full spectral absorption range, and high biosafety, achieving a record-high antibacterial activity under visible light irradiation. The experimental and theoretical results confirm that the CTF structure broadens the light absorption range of carbon nitride and enhances the separation efficiency of photogenerated electron–hole pairs, which improves the photocatalytic activity. The unique CTF structure not only exhibits excellent antibacterial activity toward both Escherichia coli and Staphylococcus aureus but also eradicates Staphylococcus aureus in a mouse wound infection model and greatly promotes wound healing. The in vivo toxicity evaluation was conducted on the physiological activities of Drosophila, confirming the high biosafety and great potential of as-prepared CTF/poly(vinyl alcohol) hydrogel for antibacterial and wound healing applications.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Advanced Photocatalysis Techniques · Covalent Organic Framework Applications · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Chemistry and Chemical Engineering, Xi’an University of Architecture and Technology, 13 Middle Section of Yanta Road, Xi’an 710055, China

Key Laboratory of Green and High-End Utilization of Salt Lake Resources, Qinghai Engineering and Technology Research Center of Comprehensive Utilization of Salt Lake Resources, Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, 18 Xining Road, Xining 810008, China

Department of Vascular Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, 22 Hankou Road, Nanjing 210008, China

School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore

Department of Physics, Beijing Technology and Business University, 51 Fucheng Road, Beijing 100048, China

Colleges and University, Gansu University of Chinese Medicine, 35 Dingxi East Road, Lanzhou 730000, China

The Centre of Advanced Catalysis Science and Technology, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore

Funding

National Natural Science Foundation of China · Natural Science Foundation of Qinghai Province · Chinese Academy of Sciences

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