journal article·2023-05-31

Ti–Si–Zr–Zn Nanometallic Glass Substrate with a Tunable Zinc Composition for Surface-Enhanced Raman Scattering of Cytochrome c

Rong An, Hangbing Zheng, Yihui Dong, Chang Liu, Luyu Zou, Tao Feng, Aatto Laaksonen, Xiaoyan Ji

ACS Applied Materials & Interfaces· Volume 15· Issue 21
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Abstract

As a remarkably powerful analytical technique, surface-enhanced Raman scattering (SERS) continues to find applications from molecular biology and chemistry to environmental and food sciences. In search of reliable and affordable SERS substrates, the development has moved from noble metals to other diverse types of structures, e.g., nano-engineered semiconductor materials, but the cost of the enhancement factors (EF) substantially decreasing. In this work, we employ biocompatible thin films of Ti–Si–Zr–Zn nanometallic glasses as the SERS substrates, while tuning the Zn composition. Aided by quartz crystal microbalance, we find that the composition of 4.3% Zn (Ti–Si–Zr–Zn 4.3 ) gives an ultrasensitive detection of Cytochrome c (Cyt c ) with an EF of 1.38 × 10 4, 10-fold higher than the previously reported EF in the semiconducting metal oxide nanomaterials, such as TiO 2, and even comparable to the reported noble-metal-assisted semiconducting tungsten oxide hydrate. Ti–Si–Zr–Zn 4.3 exhibits a stronger adhesion force toward Cyt c, which ensures the strong binding of Cyt c to the surface, facilitating the Cyt c adsorption onto the surface and thus enhancing the SERS signal. The high separation efficiency of photoinduced electrons and holes in Ti–Si–Zr–Zn 4.3 is also acknowledged for promoting the SERS activity.
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Research context

OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Quantum Dots Synthesis And Properties · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Herbert Gleiter Institute of Nanoscience, School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China

Department of Molecular Chemistry and Materials Science, Weizmann Institute of Science, Rehovot 76100, Israel

State Key Laboratory of Materials-Oriented and Chemical Engineering, Nanjing Tech University, Nanjing 210009, P. R. China

Department of Engineering Sciences and Mathematics, Division of Energy Science, Luleå University of Technology, 97187 Luleå, Sweden

Department of Materials and Environmental Chemistry, Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden

Centre of Advanced Research in Bionanoconjugates and Biopolymers, Petru Poni Institute of Macromolecular Chemistry, Aleea Grigore Ghica-Voda, 41A, 700487 Iasi, Romania

Department of Chemical and Geological Sciences, University of Cagliari, Campus Monserrato, SS 554 Bivio per Sestu, 09042 Monserrato, Italy

Funding

Vetenskapsr?det · Kempe Foundation · HORIZON EUROPE Widening participation and spreading excellence · China Postdoctoral Science Foundation · Fundamental Research Funds for the Central Universities · National Natural Science Foundation of China

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