DataVXACS Applied Materials & InterfacesPaper
journal article·2023-09-13

Lung Toxicity and Molecular Mechanisms of Lead-Based Perovskite Nanoparticles in the Respiratory System

Xuefeng Ding, Rendong He, Tingjun Zhang, Linqiang Mei, Shuang Zhu, Chengyan Wang, You Liao, Dongmei Wang, Hao Wang, Junsong Guo, Li Chen, Zhanjun Gu, Houxiang Hu

ACS Applied Materials & Interfaces· Volume 15· Issue 36
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Source abstract

Abstract

Lead-based perovskite nanoparticles (Pb-PNPs) have found extensive applications across diverse fields. However, because of poor stability and relatively strong water solubility, the potential toxicity of Pb-PNPs released into the environment during their manufacture, usage, and disposal has attracted significant attention. Inhalation is a primary route through which human exposure to Pb-PNPs occurs. Herein, the toxic effects and underlying molecular mechanisms of Pb-PNPs in the respiratory system are investigated. The in vitro cytotoxicity of CsPbBr 3 nanoparticles in BEAS-2B cells is studied using multiple bioassays and electron microscopy. CsPbBr 3 nanoparticles of different concentrations induce excessive oxidative stress and cell apoptosis. Furthermore, CsPbBr 3 nanoparticles specifically recruit the TGF-β1, which subsequently induces epithelial–mesenchymal transition. In addition, the biodistribution and lung toxicity of representative CsPbBr 3 nanoparticles in ICR mice are investigated following intranasal administration. These findings indicate that CsPbBr 3 nanoparticles significantly induce pulmonary inflammation and epithelial–mesenchymal transition and can even lead to pulmonary fibrosis in mouse models. Above findings expose the adverse effects and molecular mechanisms of Pb-PNPs in the lung, which broadens the safety data of Pb-PNPs.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsElectronic materials

OpenAlex topics: Perovskite Materials and Applications · Air Quality and Health Impacts · Sulfur Compounds in Biology

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Academician Workstation, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, P. R. China

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China

Department of Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, P. R. China

Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, P. R. China

Department of Infectious Diseases, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, P. R. China

Center of Materials Science and Optoelectronics Engineering, College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing 100049, P. R. China

CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, Beijing 100190, P. R. China

Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, P. R. China

Funding

National Key Research and Development Program of China · Department of Science and Technology of Sichuan Province · Beijing Municipal Natural Science Foundation · Chinese Academy of Sciences · Science and Technology Project of Nanchong · Research Project Foundation of Affiliated Hospital of North Sichuan Medical College

References (60)

Show source-provided references
1. 10.1021/ja809598r10.1021/ja809598r ↗
2. 10.1002/adma.20200500010.1002/adma.202005000 ↗
3. 10.1002/adma.20210627810.1002/adma.202106278 ↗
4. 10.1126/science.abj118610.1126/science.abj1186 ↗
5. 10.1002/adma.20210793210.1002/adma.202107932 ↗
6. 10.1021/acs.accounts.1c0034310.1021/acs.accounts.1c00343 ↗
7. 10.1126/science.abq701310.1126/science.abq7013 ↗
8. 10.1038/s41560-022-01096-510.1038/s41560-022-01096-5 ↗
9. 10.1021/acs.chemrev.1c0018110.1021/acs.chemrev.1c00181 ↗
10. 10.1039/D1NR05667K10.1039/D1NR05667K ↗
11. 10.1038/nnano.2015.9010.1038/nnano.2015.90 ↗
12. 10.1038/s41928-022-00712-210.1038/s41928-022-00712-2 ↗
13. 10.1038/s41467-021-21805-010.1038/s41467-021-21805-0 ↗
14. 10.1038/s41586-018-0451-110.1038/s41586-018-0451-1 ↗
15. 10.1002/advs.20220083110.1002/advs.202200831 ↗
16. 10.1038/s41563-022-01331-010.1038/s41563-022-01331-0 ↗
17. 10.1016/j.joule.2020.07.02510.1016/j.joule.2020.07.025 ↗
18. 10.1038/s41467-019-13910-y10.1038/s41467-019-13910-y ↗
19. 10.1021/acsabm.2c0029510.1021/acsabm.2c00295 ↗
20. 10.1021/acs.jpclett.1c0196810.1021/acs.jpclett.1c01968 ↗
21. 10.1016/j.scitotenv.2019.13513410.1016/j.scitotenv.2019.135134 ↗
22. 10.1002/aenm.20220414410.1002/aenm.202204144 ↗
23. 10.1016/j.tree.2022.01.00210.1016/j.tree.2022.01.002 ↗
24. Agency for Toxic Substances and Disease Registry (ATSDR) · 2020
25. 10.1016/j.envres.2021.11098010.1016/j.envres.2021.110980 ↗
26. 10.1016/j.jalz.2013.02.01210.1016/j.jalz.2013.02.012 ↗
27. 10.3389/fphar.2020.55624810.3389/fphar.2020.556248 ↗
28. 10.1006/enrs.1999.401110.1006/enrs.1999.4011 ↗
29. 10.1016/j.toxlet.2019.10.01210.1016/j.toxlet.2019.10.012 ↗
30. World Health Organization. Lead poisoning. https://www.who.int/news-room/fact-sheets/detail/lead-poisoning-and-health (accessed August 31, 2022).
31. 10.1186/1743-8977-7-210.1186/1743-8977-7-2 ↗
32. 10.1093/toxsci/kfm08810.1093/toxsci/kfm088 ↗
33. 10.3390/pharmaceutics1211102510.3390/pharmaceutics12111025 ↗
34. 10.1161/hc0402.10411810.1161/hc0402.104118 ↗
35. 10.1093/rpd/ncm24910.1093/rpd/ncm249 ↗
36. 10.1080/17435390.2018.143867910.1080/17435390.2018.1438679 ↗
37. 10.3390/ijerph1721822110.3390/ijerph17218221 ↗
38. 10.1016/j.nantod.2023.10183010.1016/j.nantod.2023.101830 ↗
39. 10.1021/acsnano.8b0420910.1021/acsnano.8b04209 ↗
40. 10.1002/smll.20197028610.1002/smll.201970286 ↗
41. 10.1002/smll.20230112910.1002/smll.202301129 ↗
42. 10.1021/acs.est.2c0398010.1021/acs.est.2c03980 ↗
43. 10.1002/smll.20190691510.1002/smll.201906915 ↗
44. 10.1016/j.ecoenv.2020.11123110.1016/j.ecoenv.2020.111231 ↗
45. 10.1002/advs.20200279710.1002/advs.202002797 ↗
46. 10.1016/j.cej.2021.13172510.1016/j.cej.2021.131725 ↗
47. 10.1002/smll.20210203510.1002/smll.202102035 ↗
48. 10.1183/09059180.0000441310.1183/09059180.00004413 ↗
49. 10.1038/nrm375810.1038/nrm3758 ↗
50. 10.1080/17435390.2022.203082210.1080/17435390.2022.2030822 ↗
51. 10.1016/j.taap.2019.04.01310.1016/j.taap.2019.04.013 ↗
52. 10.1016/j.tiv.2016.09.00310.1016/j.tiv.2016.09.003 ↗
53. 10.1038/s41580-021-00442-x10.1038/s41580-021-00442-x ↗
54. 10.1016/j.devcel.2021.02.02810.1016/j.devcel.2021.02.028 ↗
55. 10.1146/annurev-pathol-042320-03024010.1146/annurev-pathol-042320-030240 ↗
56. 10.1152/physrev.00021.201810.1152/physrev.00021.2018 ↗
57. 10.1016/j.carbpol.2021.11856710.1016/j.carbpol.2021.118567 ↗
58. 10.1002/adma.20200391310.1002/adma.202003913 ↗
59. 10.1016/j.etap.2016.06.00810.1016/j.etap.2016.06.008 ↗
60. 10.1016/j.chemosphere.2020.12875810.1016/j.chemosphere.2020.128758 ↗