DataVXACS Applied Materials & InterfacesPaper
journal article·2023-10-04

Accelerated Bone Regeneration on the Metal Surface through Controllable Surface Potential

Weiming Lin, Zhiyuan Zhou, Zhuoneng Chen, Kaicheng Xu, Chengwei Wu, Xiyue Duan, Lingqing Dong, Zuobing Chen, Wenjian Weng, Kui Cheng

ACS Applied Materials & Interfaces· Volume 15· Issue 39
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Source abstract

Abstract

Surface potential is rarely investigated as an independent factor in influencing tissue regeneration on the metal surface. In this work, the surface potential on the titanium (Ti) surface was designed to be tailored and adjusted independently, which arises from the ferroelectricity and piezoelectricity of poled poly(vinylidene fluoride-trifluoroethylene) (PVTF). Notably, it is found that such controllable surface potential on the metal surface significantly promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in vitro as well as bone regeneration in vivo. In addition, the intracellular calcium ion (Ca 2+ ) concentration measurement further proves that such controllable surface potential on the metal surface could activate the transmembrane calcium channels and allow the influx of extracellular Ca 2+ into the cytoplasm. That might be the reason for improved osteogenic differentiation of BMSCs and bone regeneration. These findings reveal the potential of the metal surface with improved bioactivity for stimulation of osteogenesis and show great prospects for fabricable implantable medical devices with adjustable surface potential.
Source: openalex_inverted_index · Quality: baseline

Research context

BiomaterialsElectronic materials

OpenAlex topics: Bone Tissue Engineering Materials · Advanced Sensor and Energy Harvesting Materials · 3D Printing in Biomedical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Materials Science and Engineering, Center of Rehabilitation Biomedical Materials, Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou 310027, Peoples R China

Department of Gastroenterology, Zhejiang University School of Medicine, Affiliated Hospital 1, Hangzhou 310003, Peoples R China

Department of Orthopedics, Zhejiang University School of Medicine, Affiliated Hospital 2, Hangzhou 310009, Peoples R China

Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Province Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou 310006, Peoples R China

Department of Rehabilitation Medicine, Zhejiang University School of Medicine, Affiliated Hospital 1, Hangzhou 310003, Peoples R China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China

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