In Vivo Glutamate Sensing inside the Mouse Brain with Perovskite Nickelate–Nafion Heterostructures
Source abstract
Abstract
Glutamate, one of the main neurotransmitters in the brain, plays a critical role in communication between neurons, neuronal development, and various neurological disorders. Extracellular measurement of neurotransmitters such as glutamate in the brain is important for understanding these processes and developing a new generation of brain–machine interfaces. Here, we demonstrate the use of a perovskite nickelate–Nafion heterostructure as a promising glutamate sensor with a low detection limit of 16 nM and a response time of 1.2 s via amperometric sensing. We have designed and successfully tested novel perovskite nickelate–Nafion electrodes for recording of glutamate release ex vivo in electrically stimulated brain slices and in vivo from the primary visual cortex (V1) of awake mice exposed to visual stimuli. These results demonstrate the potential of perovskite nickelates as sensing media for brain–machine interfaces.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Memory and Neural Computing · Conducting polymers and applications · Perovskite Materials and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Materials Engineering, Purdue University, West Lafayette, Indiana 47907, United States
Birck Nanotechnology Center, Center for Implantable Device, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States
Department of Biological Sciences, Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana 47907, United States
Center for Nanoscale Materials, Argonne National Laboratory, Lemont, Illinois 60439, United States
X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, Lemont, Illinois 60439, United States
Funding
Air Force Office of Scientific Research
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