journal article·2021-06-16

Hyalase-Mediated Cascade Degradation of a Matrix Barrier and Immune Cell Penetration by a Photothermal Microneedle for Efficient Anticancer Therapy

Ting He, Yu Luo, Qin Zhang, Zening Men, Tong Su, Linpeng Fan, Hangrong Chen, Teng Shen

ACS Applied Materials & Interfaces· Volume 13· Issue 23
Publisher page

Abstract

For melanoma with high lethality and metastasis rate, traditional therapy has limited effects; local photothermal therapy (PTT) synergetic with immune therapy for cancer treatment can perhaps improve the situation. However, because of the natural existence of the tumor matrix barrier, the penetration depth of drugs and immune cells often dampens the efficacy of cancer treatment. Herein, we report an innovative synergetic PTT and immune therapy through dissolving microneedles for the codelivery of the hyaluronidase-modified semiconductor polymer nanoparticles containing poly(cyclopentadithiophene-alt-benzothiadiazole) and immune adjuvant polyinosinic–polycytidylic acid (PIC). Benefiting from the dissolution of an extracellular matrix of hyaluronidase, the semiconductor polymer nanoparticles and PIC penetrate the tumor deeply, under synergetic therapy with PTT, activating the immune cells and enhancing the T-cell immune response for inhibition of tumor growth and metastasis. This study provides a promising platform for effective melanoma treatment and a novel strategy to overcome the stromal barrier.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Advancements in Transdermal Drug Delivery · Immunotherapy and Immune Responses

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai 201203, P.R. China

State Key Laboratory of High-Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P.R. China

Frontier Institute of Medical & Pharmaceutical Science and Technology, College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, No. 333 Longteng Road, Shanghai 201620, P.R. China

Institute of Translational Medicine, Shanghai University, Shanghai 200444, P.R. China

Institute for Frontier Materials, Deakin University, Geelong, Victoria 3216, Australia

Funding

National Natural Science Foundation of China · State Key Laboratory of High Performance Ceramics and Superfine Microstructure · Key Program for Basic Research of Shanghai · Development Project of Shanghai Peak Disciplines-Integrative Medicine of The Institutes of Integrative Medicine of Fudan University

References (52)

Show source-provided references
1. 10.1016/j.canlet.2014.11.00110.1016/j.canlet.2014.11.001 ↗
2. 10.1021/nn301218z10.1021/nn301218z ↗
3. 10.1021/ja057254a10.1021/ja057254a ↗
4. 10.1038/nmat470710.1038/nmat4707 ↗
5. 10.1016/j.cej.2018.06.10010.1016/j.cej.2018.06.100 ↗
6. 10.1002/adma.20130525610.1002/adma.201305256 ↗
7. 10.1016/j.biomaterials.2014.10.00110.1016/j.biomaterials.2014.10.001 ↗
8. 10.1002/anie.20171014410.1002/anie.201710144 ↗
9. 10.1021/acs.nanolett.6b0406010.1021/acs.nanolett.6b04060 ↗
10. 10.1002/ijc.3171710.1002/ijc.31717 ↗
11. 10.1016/j.biomaterials.2017.11.02510.1016/j.biomaterials.2017.11.025 ↗
12. 10.1039/C6TB03393H10.1039/C6TB03393H ↗
13. 10.1002/smtd.20190055310.1002/smtd.201900553 ↗
14. 10.1002/adma.20170598010.1002/adma.201705980 ↗
15. 10.1021/acsnano.8b0406610.1021/acsnano.8b04066 ↗
16. 10.1038/s41571-020-0410-210.1038/s41571-020-0410-2 ↗
17. 10.1016/j.copbio.2017.03.00110.1016/j.copbio.2017.03.001 ↗
18. 10.1016/j.ejpb.2018.02.01410.1016/j.ejpb.2018.02.014 ↗
19. 10.1016/j.ejps.2017.11.03110.1016/j.ejps.2017.11.031 ↗
20. 10.1016/j.ijpharm.2017.09.05510.1016/j.ijpharm.2017.09.055 ↗
21. 10.1089/hum.2011.21110.1089/hum.2011.211 ↗
22. 10.1016/j.jconrel.2015.05.27810.1016/j.jconrel.2015.05.278 ↗
23. 10.1021/acs.nanolett.5b0503010.1021/acs.nanolett.5b05030 ↗
24. 10.1002/adma.20150602510.1002/adma.201506025 ↗
25. 10.1021/acsnano.6b0498910.1021/acsnano.6b04989 ↗
26. 10.1016/j.ejso.2016.07.14510.1016/j.ejso.2016.07.145 ↗
27. 10.4161/onci.1989410.4161/onci.19894 ↗
28. 10.1016/j.apjtm.2016.03.01910.1016/j.apjtm.2016.03.019 ↗
29. 10.1158/1078-0432.CCR-17-186610.1158/1078-0432.CCR-17-1866 ↗
30. 10.1002/eji.20184788810.1002/eji.201847888 ↗
31. 10.4049/jimmunol.160018210.4049/jimmunol.1600182 ↗
32. 10.1016/j.biomaterials.2019.11941710.1016/j.biomaterials.2019.119417 ↗
33. 10.7150/thno.2974610.7150/thno.29746 ↗
34. 10.1038/nrd130410.1038/nrd1304 ↗
35. 10.1101/gad.191999.11210.1101/gad.191999.112 ↗
36. 10.1021/acsami.7b1829310.1021/acsami.7b18293 ↗
37. 10.1016/j.jconrel.2020.05.00610.1016/j.jconrel.2020.05.006 ↗
38. 10.1002/smll.20180299110.1002/smll.201802991 ↗
39. 10.1038/ni.270310.1038/ni.2703 ↗
40. 10.1158/0008-5472.CAN-07-532410.1158/0008-5472.CAN-07-5324 ↗
41. 10.1126/science.119844310.1126/science.1198443 ↗
42. 10.1046/j.1523-1747.2000.00992.x10.1046/j.1523-1747.2000.00992.x ↗
43. 10.2217/nnm-2017-014510.2217/nnm-2017-0145 ↗
44. 10.1088/0957-4484/27/13/13510210.1088/0957-4484/27/13/135102 ↗
45. 10.1002/adma.20120468310.1002/adma.201204683 ↗
46. 10.1021/acs.nanolett.6b0082010.1021/acs.nanolett.6b00820 ↗
47. 10.1016/j.ijbiomac.2018.05.09710.1016/j.ijbiomac.2018.05.097 ↗
48. 10.1016/j.jconrel.2012.01.04210.1016/j.jconrel.2012.01.042 ↗
49. 10.1038/s41598-018-26978-110.1038/s41598-018-26978-1 ↗
50. 10.1021/acs.nanolett.9b0057910.1021/acs.nanolett.9b00579 ↗
51. 10.1016/0167-5699(96)80606-210.1016/0167-5699(96)80606-2 ↗
52. 10.1002/adma.20190019210.1002/adma.201900192 ↗