DataVXACS Applied Materials & InterfacesPaper
journal article·2020-03-11

Virus-Like Fe3O4@Bi2S3 Nanozymes with Resistance-Free Apoptotic Hyperthermia-Augmented Nanozymitic Activity for Enhanced Synergetic Cancer Therapy

Yajie Zhao, Binbin Ding, Xiao Xiao, Fan Jiang, Meifang Wang, Zhiyao Hou, Bengang Xing, Bo Teng, Ziyong Cheng, Ping’an Ma, Jun Lin

ACS Applied Materials & Interfaces· Volume 12· Issue 10
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Source abstract

Abstract

Nanomaterials with intrinsic peroxidase-like activities are able to catalyze the oxidation of the substrate with the peroxide, which have been widely considered as artificial enzymatic agents in cancer therapy. However, current peroxidase catalytic oxidation treatments generating reactive oxygen species rely highly on hydrogen peroxide and pH, which limit greatly their therapeutic efficiency in the tumor microenvironment. Here, we report a strategy to construct the complex virus-like Fe3O4@Bi2S3 nanocatalysts (F-BS NCs) by connecting typical peroxidase Fe3O4 (MNPs) with a narrow band gap semiconductor Bi2S3 (BS) to enhance the enzymatic activity resorting to the limited intratumoral peroxide and efficient external photothermal stimuli. In this formulation, the integrated F-BS NCs induce cancer-cell death through mild photothermal treatment and sequential photothermal-stimulative catalysis of H2O2 into highly toxic •OH under 808 nm laser, which successfully realize a remarkable synergistic anticancer achievement.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsElectronic materialsCatalysis & surfaces

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China

University of Science and Technology of China, No. 96, JinZhai Road, Baohe District, Hefei, Anhui 230026, P. R. China

School of Physical & Mathematical Sciences, Nanyang Technological University, 637371, Singapore

Department of Otolaryngology Head and Neck Surgery, The Second Hospital, Jilin University, Changchun 130041, China

Funding

Ministry of Science and Technology of the People's Republic of China · Department of Industry and Science, Australian Government · Youth Innovation Promotion Association of the Chinese Academy of Sciences · People's Government of Jilin Province · Croucher Foundation · National Natural Science Foundation of China · Chinese Academy of Sciences · Guangdong Province · Jiangmen Innovative Research Team Program

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