Plasmonic Resonance Energy Transfer Enhanced Photodynamic Therapy with Au@SiO2@Cu2O/Perfluorohexane Nanocomposites
Source abstract
Abstract
Reactive oxygen species generation efficiency of photosensitizers and hypoxia microenvironment in solid tumor hamper photodynamic therapy (PDT) efficacy. Here, we introduce an efficient inorganic photosensitizer by incorporating plasmonic gold metal nanostructures into Cu 2 O semiconductors for PDT. By utilizing the plasmon-induced resonance energy transfer (PIRET) process from Au to Cu 2 O, Au@SiO 2 @Cu 2 O (ASC) demonstrates a high singlet oxygen quantum yield of 0.71 under a 670 nm laser irradiation. The ASC is loaded into oxygen self-enriched perfluorohexane (PFH) droplets and coated with liposome (Lip) to form Lip(ASC/PFH) nanocomposites. The achieved Lip(ASC/PFH) shows considerable anticancer efficacy for in vitro cancer cells and in vivo tumor growth. The proposed oxygen self-enriched PIRET-PDT concept has significant implication in PDT design.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Photoacoustic and Ultrasonic Imaging
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Research Center for Bioengineering & Sensing Technology, School of Chemistry & Biological Engineering, University of Science & Technology Beijing, Beijing 100083, P. R. China
Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, West Virginia 26506-6106, United States
Funding
Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Beijing Key Laboratory of Plant Resources Research and Development, Beijing Technology and Business University
References (58)
Show source-provided references
1. 10.3322/caac.2010710.3322/caac.20107 ↗
2. 10.1021/acsami.6b1444610.1021/acsami.6b14446 ↗
3. 10.1039/C6CS00616G10.1039/C6CS00616G ↗
4. 10.1021/cr500419810.1021/cr5004198 ↗
5. 10.1039/c0an00144a10.1039/c0an00144a ↗
6. 10.1039/C6CS00271D10.1039/C6CS00271D ↗
7. 10.1021/acsami.6b1286510.1021/acsami.6b12865 ↗
8. 10.1016/0167-5699(94)90018-310.1016/0167-5699(94)90018-3 ↗
9. 10.1021/acsnano.6b0140110.1021/acsnano.6b01401 ↗
10. 10.1038/nnano.2015.1710.1038/nnano.2015.17 ↗
11. 10.1021/nn506107c10.1021/nn506107c ↗
12. 10.1007/s12274-015-0712-310.1007/s12274-015-0712-3 ↗
13. 10.1021/ja038690510.1021/ja0386905 ↗
14. 10.2217/nnm.09.910.2217/nnm.09.9 ↗
15. 10.1016/j.sder.2008.08.00310.1016/j.sder.2008.08.003 ↗
16. 10.1002/anie.20131009710.1002/anie.201310097 ↗
17. 10.1002/adma.20110090510.1002/adma.201100905 ↗
18. 10.1021/jacs.5b0968210.1021/jacs.5b09682 ↗
19. 10.1021/acs.jpclett.5b0239310.1021/acs.jpclett.5b02393 ↗
20. 10.1021/ja305603t10.1021/ja305603t ↗
21. 10.1002/smtd.20160003210.1002/smtd.201600032 ↗
22. 10.1002/adma.20170481110.1002/adma.201704811 ↗
23. 10.1038/nphoton.2015.14210.1038/nphoton.2015.142 ↗
24. 10.1016/j.elecom.2004.06.00810.1016/j.elecom.2004.06.008 ↗
25. 10.1021/jp904198d10.1021/jp904198d ↗
26. 10.1021/nn300934k10.1021/nn300934k ↗
27. 10.1021/acs.nanolett.6b0236510.1021/acs.nanolett.6b02365 ↗
28. 10.1002/adfm.20160067610.1002/adfm.201600676 ↗
29. 10.1002/anie.20151074810.1002/anie.201510748 ↗
30. 10.1002/adma.20160190210.1002/adma.201601902 ↗
31. 10.1021/ja511420n10.1021/ja511420n ↗
32. 10.1021/acs.nanolett.6b0006810.1021/acs.nanolett.6b00068 ↗
33. 10.1016/j.biomaterials.2012.02.01610.1016/j.biomaterials.2012.02.016 ↗
34. 10.1038/ncomms978510.1038/ncomms9785 ↗
35. 10.1111/j.1525-1594.2009.00944.x10.1111/j.1525-1594.2009.00944.x ↗
36. 10.1002/adma.20150461710.1002/adma.201504617 ↗
37. 10.1021/la960187110.1021/la9601871 ↗
38. 10.1021/ja906533310.1021/ja9065333 ↗
39. 10.1021/acs.langmuir.6b0033110.1021/acs.langmuir.6b00331 ↗
40. 10.1021/la503988e10.1021/la503988e ↗
41. 10.1016/j.jallcom.2016.09.29110.1016/j.jallcom.2016.09.291 ↗
42. 10.1021/la503988e10.1021/la503988e ↗
43. 10.1021/cs100117v10.1021/cs100117v ↗
44. 10.1016/j.biomaterials.2013.06.04510.1016/j.biomaterials.2013.06.045 ↗
45. 10.1021/jacs.5b0602510.1021/jacs.5b06025 ↗
46. 10.1111/j.1751-1097.1999.tb08240.x10.1111/j.1751-1097.1999.tb08240.x ↗
47. 10.1021/cs300672f10.1021/cs300672f ↗
48. 10.1002/adma.20160219710.1002/adma.201602197 ↗
49. 10.1021/acsnano.6b0752510.1021/acsnano.6b07525 ↗
50. 10.1186/cc36410.1186/cc364 ↗
51. 10.1007/s11051-013-1507-710.1007/s11051-013-1507-7 ↗
52. 10.2217/nnm.15.17810.2217/nnm.15.178 ↗
53. 10.14348/molcells.2016.219810.14348/molcells.2016.2198 ↗
54. 10.1021/acsami.6b1315010.1021/acsami.6b13150 ↗
55. 10.1021/ja408286k10.1021/ja408286k ↗
56. 10.1016/j.biomaterials.2012.07.00310.1016/j.biomaterials.2012.07.003 ↗
57. 10.1038/nrc189310.1038/nrc1893 ↗
58. 10.1016/j.drudis.2016.06.02410.1016/j.drudis.2016.06.024 ↗