Gold Nanoparticle-Decorated g-C3N4 Nanosheets for Controlled Generation of Reactive Oxygen Species upon 670 nm Laser Illumination
Source abstract
Abstract
Conventional photosensitizer-based photodynamic therapy is triggered by UV-light irradiation and depends on oxygen. However, it is hard to be applied to the deep and hypoxic tumor. To address this issue, we reported a new kind of g-C3N4 nanosheet decorated with gold nanoparticles (AuNPs), which could generate a high amount of reactive oxygen species (ROS) under a 670 nm laser irradiation in an oxygen-free environment. This synthesized semiconductor-metal heterojunction served as a superior photodynamic agent, showing prominent cancer cell-killing and tumor growth-suppressing effects in the presence of a 670 nm light and g-C3N4-AuNP composites, and its excellent ROS generation property was also validated by further bactericidal experiment.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Photocatalysis Techniques · Advanced Nanomaterials in Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, P. R. China
MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350116, P. R. China
Funding
National Natural Science Foundation of China · Center for Global Health, Nanjing Medical University · Priority Academic Program Development of Jiangsu Higher Education Institutions
References (39)
Show source-provided references
1. 10.1038/nrc107010.1038/nrc1070 ↗
2. 10.1021/cr900300p10.1021/cr900300p ↗
3. 10.1002/adfm.20170749610.1002/adfm.201707496 ↗
4. 10.1038/nrc189410.1038/nrc1894 ↗
5. 10.1093/jnci/djm13510.1093/jnci/djm135 ↗
6. 10.1021/jacs.7b0239610.1021/jacs.7b02396 ↗
7. 10.1038/nrd261410.1038/nrd2614 ↗
8. 10.1002/adma.20160190210.1002/adma.201601902 ↗
9. 10.1021/nn506107c10.1021/nn506107c ↗
10. 10.1002/adma.20170167410.1002/adma.201701674 ↗
11. 10.1021/acs.chemrev.6b0007510.1021/acs.chemrev.6b00075 ↗
12. 10.1002/adfm.20170269510.1002/adfm.201702695 ↗
13. 10.1021/ja308249k10.1021/ja308249k ↗
14. 10.1002/anie.20160550910.1002/anie.201605509 ↗
15. 10.1038/natrevmats.2017.3010.1038/natrevmats.2017.30 ↗
16. 10.1016/j.trac.2016.03.00210.1016/j.trac.2016.03.002 ↗
17. 10.1002/smll.20160168110.1002/smll.201601681 ↗
18. 10.1039/c3cy20836b10.1039/c3cy20836b ↗
19. 10.1016/j.apcatb.2013.09.00210.1016/j.apcatb.2013.09.002 ↗
20. 10.1039/C4CS00126E10.1039/C4CS00126E ↗
21. 10.1002/aenm.20170150310.1002/aenm.201701503 ↗
22. 10.1039/C6CS00616G10.1039/C6CS00616G ↗
23. 10.1007/s12274-018-2075-z10.1007/s12274-018-2075-z ↗
24. 10.1002/smll.20170281510.1002/smll.201702815 ↗
25. 10.1021/acs.chemmater.6b0359810.1021/acs.chemmater.6b03598 ↗
26. 10.1021/acsami.7b0065110.1021/acsami.7b00651 ↗
27. 10.1039/C7BM00798A10.1039/C7BM00798A ↗
28. 10.1039/C4CS00011K10.1039/C4CS00011K ↗
29. 10.1021/acsnano.6b0581010.1021/acsnano.6b05810 ↗
30. 10.1021/nn503450t10.1021/nn503450t ↗
31. 10.1038/nrd196010.1038/nrd1960 ↗
32. 10.1039/C4CP02021A10.1039/C4CP02021A ↗
33. 10.1021/jacs.7b0670810.1021/jacs.7b06708 ↗
34. 10.1016/j.biomaterials.2012.02.04910.1016/j.biomaterials.2012.02.049 ↗
35. 10.1016/j.bbamem.2009.09.01410.1016/j.bbamem.2009.09.014 ↗
36. 10.1039/c3nr05112a10.1039/c3nr05112a ↗
37. 10.1021/acsnano.5b0336810.1021/acsnano.5b03368 ↗
38. 10.1039/C7NR06807G10.1039/C7NR06807G ↗
39. 10.1021/jacs.5b1141110.1021/jacs.5b11411 ↗