ADVANCED HEALTHCARE MATERIALS

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Huixiang Lan, Danlin Ou, Chaoming Mei, Yufei Qin et al.

ABSTRACT Sacituzumab govitecan (SG), a trophoblast cell surface antigen 2 (TROP2)‐targeting antibody‐drug conjugate, is effective against solid tumors and a promising carrier for molecular imaging, yet its role in near‐infrared (NIR) fluorescence imaging of metastases is unclear. Based on the dual rationale of frequent lymph node metastasis in esophageal squamous cell carcinoma…

Qing Zhou, Wenwei Zhao, Suyun Li, Yixuan Wang et al.

ABSTRACT Extensive bone defects complicated by infection, malignancy, or metabolic disorders remain a critical clinical challenge, as conventional calcium phosphate bioceramics provide only passive osteoconductive support. The integration of additive manufacturing with external physical stimuli, such as mechanical, piezoelectric, photothermal, magnetothermal, and ultrasonic, ha…

Shuang Liu, Hewen Li, Yuhang Ding, Dengyi Duan et al.

ABSTRACT Ferroptosis is triggered by iron‐dependent lipid peroxidation, which shows great potential in tumor therapy. However, its biomedical applications are constrained by suboptimal therapeutic efficacy, leakage of metal ions from inducing agents, and the absence of noninvasive evaluation methods. In this study, we aimed to develop a self‐reducing nano‐theranostic agent (Fe@…

Huixi Yi, Yue Zheng, Nannan Fu, Qiuhua Li et al.

ABSTRACT Hypoxia in the tumor microenvironment (TME) is a hallmark of solid tumors and is tightly associated with the development of chemoresistance and immunosuppression, severely compromising the efficacy of mainstream clinical oncological treatments. Platinum‐based metallodrugs, especially oxaliplatin (Oxa), serve as first‐line chemotherapeutics in clinical practice. However…

Yingying Li, Chen Hu, Keyi Fang, Qiang Li et al.

ABSTRACT Clinical management of chronic wounds remains a major challenge, stemming from their complex etiology, high infection risk, and pronounced inter‐patient variability. While nanomaterials offer innovative solutions to overcome the limitations of conventional therapies via tunable physicochemical and biological properties, research into their rational design for chronic w…

A. Aslihan Gokaltun, Dinesh Shrestha, Carolina Dos Anjos, Nafiseh Khoshnevisan et al.

ABSTRACT Burn wound infections, caused by Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) , remain a major clinical challenge, delaying healing and increasing the risk of mortality. Gentamicin sulfate (GEN) is a broad‐spectrum antibiotic widely used for infection control. However, conventional GEN‐loaded hydrogels often suffer from burst release and…

Juanjuan Zheng, Hui Liu, Yaosheng Li, Yuankai Sun et al.

ABSTRACT Blood–brain barrier (BBB) disruption is found in many acute and chronic inflammatory encephalopathies. Timely restoration of BBB integrity is essential for controlling disease progression, especially in ischemic stroke. While various brain‐targeting strategies have been developed, achieving precise BBB‐targeting and sustained retention at the BBB to enable faster and m…

Yun Seop Shim, Sung Min Han, Yun Kee Jo

ABSTRACT Lung cancer remains a leading cause of cancer‐related mortality worldwide, with metastatic disease accounting for ∼90% of deaths. While p53 gene therapy offers promise for restoring tumor suppressor function, its clinical translation has been hindered by inefficient delivery systems and pulmonary administration challenges. Here, we developed redox‐responsive thiolated …

Tingting Chen, Jiaying Li, Tao Lin, Jiamin Li et al.

ABSTRACT Osteonecrosis of the femoral head (ONFH) is a debilitating condition caused by compromised local blood supply to the femoral head, which leads to bone tissue death. The primary therapeutic goals are to restore blood perfusion and reconstruct the damaged bone structure. In this study, we present an advanced three dimensional printed multifunctional composite scaffold th…

Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan et al.

ABSTRACT Translating preclinical research findings to clinical applications presents challenges due to the metabolic and anatomical disparities between animal models and humans. Although organ‐on‐a‐chip models replicate the organization of human cells, they lack the complexity of the microenvironment and anatomical fidelity. Developing alternative research models with greater p…

Sabrina Stecher, Joachim Schenk, Alessandro Cianciosi, Katherina Hemmen et al.

ABSTRACT In breast cancer, local invasion of cancer cells into surrounding tissue marks the first step of metastasis. However, to elucidate the impact of cells from the tumor microenvironment on this process, advanced 3D migration models are still urgently needed. To enable migration and invasion studies in a fully 3D bioprinted tumor‐stroma model, a migration‐permissive bioink…

Pragti, Bidyut Kumar Kundu, Jiajie Diao, Yujie Sun

ABSTRACT The design of organic photosensitizers that operate efficiently in the near‐infrared (NIR) region remains challenging due to the need to balance electronic delocalization, stability, and biological compatibility. Here we report a rational, electronegativity‐guided strategy for engineering (donor–π) ₃ –acceptor pyrylium‐based chromophores capable of concurrent NIR ph…

Xi Lin, Jian Lin, Yezi Zhang, Xinyan Zhang et al.

ABSTRACT Acute lung injury (ALI) is a lethal respiratory disease. The inflammatory storm triggered by neutrophil extracellular traps (NETs) is the critical pathogenesis of pulmonary injury. But the effective clinical treatments remain limited for ALI. Hence, developing a pulmonary‐targeting nano‐drug is urgent in the clinic. Lonicera japonica ‐derived nanovesicles (LDNVs) was i…

Xuemei Dong, Lingan Zeng, Yunlong Liu, Mingming Wang et al.

ABSTRACT Photodynamic therapy (PDT) faces significant challenges in treating solid tumors due to the hypoxic tumor microenvironment and high degree of tumor heterogeneity. To address this issue, this study employed a strategy of acceptor planarization coupled with tunable terminal aryl modulation to design and synthesize a series of type I photosensitizers (DPP‐1–DPP‐3) with sy…

Iván Cortés Domínguez, Xabier Morales Urteaga, Maider Esparza, Lucía Grande et al.

ABSTRACT Intravital microscopy (IVM) using dorsal skinfold chambers (DSCs) enables real‐time, high‐resolution imaging of the tumor microenvironment. Conventional, metal‐based DSC systems often cause animal distress and require technically demanding surgical implantation. To address these challenges and adhere to the 3Rs principles of animal welfare, this study presents a novel,…

Yuhui Wang, Simin Wei, Yingdong Zhou, Siqi Su et al.

ABSTRACT Due to the self‐delivery, self‐release, biodegradation, and biocompatibility, Chinese herbal medicine‐based self‐assembled hydrogels are recognized as promising candidates as wound dressing to dispose diabetic wound. However, most of them consist of single‐component that induces dissatisfactory therapeutic effects, imposing obstacles to their widespread applications. H…

Qipeng Wu, Yuan Xiong, Li Lu, Han Wang et al.

ABSTRACT Chronic diabetic wounds are characterized by persistent inflammation, impaired angiogenesis, and disrupted intercellular communication, including altered macrophage‐endothelial interactions. In this study, we develop macrophage membrane‐camouflaged, didymin (DM)‐loaded metal‐organic framework microneedles (Mac@DM‐MOF MNs), a biomimetic nanozyme platform designed to sel…

Zachary M. Eidman, Jhanvi Sharma, Joanne C. Lee, Nicholas F. Schulze et al.

ABSTRACT Regenerative engineering harnesses materials science and stem cell biology to develop strategies to repair damaged and diseased tissue. Despite advances in designer materials, few techniques effectively provide auto‐regulated feedback mechanisms that govern how cells sense and respond to discrete microenvironmental changes. Here, we demonstrate that the artificial, jux…

Xuan Zhang, Bin Dong, Shan Su, Xinxin Li et al.

ABSTRACT Photodynamic immunotherapy is constrained by the immunosuppressive tumor microenvironment (TME) that scavenges reactive oxygen species (ROS) and limits immunogenic cell death. Lanthanide‐doped upconversion nanoparticles enable near‐infrared‐triggered singlet oxygen generation, yet their efficacy is hampered by intrinsically low upconversion luminescence efficiency and …