Extracorporeal hydroxyapatite-chamber for bone and biomaterial studies
Source abstract
Abstract
Hydroxyapatite (HA) spherules and autologous bone (AB) with a central vascular pedicle were housed inside an HA-chamber to form the skeletal segment of specific shape. Experimental chambers were then inserted in a pocket between medial thigh muscles in 13 New Zealand male rabbits for 3 months. Three graft group were scheduled: (A) HA and AB without vascular pedicle, (B) HA with vascular pedicle, (C) HA and AB with vascular pedicle. At term, histology showed tissue and cellular degeneration in group A chambers. Due to spherules coalescence, fibrous tissue is formed in group B chambers. Group C chambers contained living osteocytes in the implanted bone, several newly formed vessels in soft tissue, bone and partial hydroxyapatite erosions. New bone was formed in apposition to both autologous bone and hydroxyapatite. Our study suggests that this experimental model could be used to grow adequately sized vascularized skeletal segments.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental Implant Techniques and Outcomes · Orthopaedic implants and arthroplasty
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (27)
Show source-provided references
1. S. C. GAMRADT and J. R. LIEBERMAN, Clin. Orthop. Relat. Res. 417 (2003) 18310.1097/01.blo.0000096814.78689.77 ↗
2. J. N. GRAUER, J. M. BEINER, B. K. KWON and A. R. VACCARO, BioDrugs 17 (2003) 39110.2165/00063030-200317060-00002 ↗
3. J UPTON, N. FERRARO, G. HEALY, R. KHOURI and C. MERREL, Plast. Reconstr. Surg. 94 (1994) 57310.1097/00006534-199410000-00001 ↗
4. Y. CAO, J. P. VACANTI, K. T. PAIGE, J. UPON and C. A. VACANTI, Plast. Reconstr. Surg. 100 (1997) 29710.1097/00006534-199708000-00001 ↗
5. N. ISOGAI, W. LANDIS, T. KIM, L. GERSTENFELD and J. UPTON, J. Bone Joint Surg. 81A (1999) 30610.2106/00004623-199903000-00002 ↗
6. Y. HORY, S. TAMAI, H. OKUDA, H. SAKAMOTO, T. TAKITA and K. MASUHARA, J. Hand Surg. 4 (1979) 2310.1016/S0363-5023(79)80101-X ↗
7. J. H. GUO, Ann. Plast. Surg. 36 (1996) 13310.1097/00000637-199602000-00005 ↗
8. G. M. GARTSMAN, A. J. WEILAND, J. R. MOORE and M. A. RANDOLPH, J. Reconstr. Microsurg. 1 (1985) 21510.1055/s-2007-1007077 ↗
9. D. R. GILL, D. C. IRELAND, J. V. HURLEY and W. A. MORRISON, J. Hand Surg. 23A (1998) 31210.1016/S0363-5023(98)80133-0 ↗
10. T. KASASHIMA, A. MINAMI, H. KATO and K. KANEDA, J. Reconstr. Microsurg. 16 (2000) 12110.1055/s-2000-7546 ↗
11. M. CELIK, S. TUNCER, U. EMEKLI and S. N. KESIM, J. Oral Maxillofac. Surg. 58 (2000) 29210.1016/S0278-2391(00)90056-9 ↗
12. R. BUSA, R. ADANI, C. CASTAGNETTI, D. ZAFFE and A. MINGIONE, Microsurgery 19 (1999) 28910.1002/(SICI)1098-2752(1999)19:6<289::AID-MICR7>3.0.CO;2-# ↗
13. H. NETTELBLAD, M. A. RANDOLPH, L. T. OSTRUP and T. I. WEILAND, Plast. Reconstr. Surg. 76 (1985) 85110.1097/00006534-198512000-00008 ↗
14. S. MIZUMOTO, Y. INADA and A. J. WEILAND, J. Reconstr. Microsurg. 8 (1992) 32510.1055/s-2007-1006716 ↗
15. S. MIZUMOTO, Y. INADA and A. J. WEILAND, J. Reconstr. Microsurg. 9 (1993) 44110.1055/s-2007-1006754 ↗
16. C. C. LIN, C. J. LIAO, J. S. SUN, H. C. LIU and F. H. LIN, Biomaterials 17 (1996) 113310.1016/0142-9612(96)85916-3 ↗
17. A. MORONI, S. GIANNINI, D. ZAFFE, A. RAVAGLIOLI, A. KRAJEWSKI, A. VENTURINI, M. POMPILI, S. CANTAGALLI, V. PEZZUTO and L. TRINCHESE, Bioceramics Vol. 2. (Köln:Deutsche Keramische Gesellschaft e.V.; 1990), p. 125
18. D. ZAFFE, BIOSIS Int. Soc. for Bio-Analog Skel Impl. (Elztal-Dallau - D:Laub GmbH & Co.; 1992), p. 63
19. D. ZAFFE, S. GIANNINI, A. MORONI, A. KRAJEWSKI and A. RAVAGLIOLI, Bioceramics and the Human Body (London: Elsevier Sci Publ Ltd, 1992), p. 38810.1007/978-94-011-2896-4_54 ↗
20. H. M. T. U. HERATH, L. DI SILVIO and J. R. G. EVANS J. Appl. Biomater. Biomech. 3 (2005) 192
21. D. ZAFFE, G. C. LEGHISSA, J. PRADELLI and A. R. BOTTICELLI, J. Mater. Sci. Mater. Med. 16 (2005) 78910.1007/s10856-005-3574-5 ↗
22. C. BERTOLDI, J. PRADELLI, U. CONSOLO and D. ZAFFE, J. Mater. Sci. Mater. Med. 16 (2005) 85710.1007/s10856-005-3575-4 ↗
23. A. M. PARFITT, M. K. DREZNER, F. H. GLORIEUX, J. A. KANIS, H. MALLUCHE and P. J. MEUNIER, J. Bone Miner. Res. 2 (1987) 59510.1002/jbmr.5650020617 ↗
24. M. FERRETTI, C. PALUMBO and G. MAROTTI, Anat. Embryol. 206 (2002) 2110.1007/s00429-002-0265-6 ↗
25. D. ZAFFE, C. BERTOLDI and U. CONSOLO, Biomaterials 25 (2004) 383710.1016/j.biomaterials.2003.10.020 ↗
26. R. R. KANIA, A. MEUNIER, M. HAMADOUCHE, L. SEDEL and H. PETITE, J. Biomed. Mater. Res. 43 (1998) 3810.1002/(SICI)1097-4636(199821)43:1<38::AID-JBM4>3.0.CO;2-N ↗
27. A. CIGADA, G. De SANCTIS, A. M. GATTI, A. ROOS and D. ZAFFE, J. Appl. Biomater. 4 (1993) 3910.1002/jab.770040105 ↗