Biodegradable β-tricalcium phosphate cement with anti-washout property based on chelate-setting mechanism of inositol phosphate
Source abstract
Abstract
Novel biodegradable β-tricalcium phosphate (β-TCP) cements with anti-washout properties were created on the basis of chelate-setting mechanism of inositol phosphate (IP6) using β-TCP powders. The β-TCP powders were ball-milled using ZrO₂ beads for 0-6 h in the IP6 solutions with concentrations from 0 to 10,000 ppm. The chelate-setting β-TCP cement with anti-washout property was successfully fabricated by mixing the β-TCP powder ball-milled in 3,000 ppm IP6 solution for 3 h and 2.5 mass% Na₂HPO₄ solution, and compressive strength of the cement was 13.4 ± 0.8 MPa. An in vivo study revealed that the above cement was directly in contact with host and newly formed bones without fibrous tissue layers, and was resorbed by osteoclast-like cells on the surface of the cement. The chelate-setting β-TCP cement with anti-washout property is promising for application as a novel injectable artificial bone with both biodegradability and osteoconductivity.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Periodontal Regeneration and Treatments · Oral and gingival health research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (38)
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1. Ishikawa K, Takagi S, Chow LC, Ishikawa Y. Properties and mechanism of fast-setting calcium phosphate cements. J Mater Sci Mater Med. 1995;6:528–33.10.1007/BF00151034 ↗
2. Gbureck U, Barralet JE, Spatz K, Grover LM, Thull R. Ionic modification of calcium phosphate cement viscosity. Part I: hypodermic injection and strength improvement of apatite cement. Biomaterials. 2004;25:2187–95.10.1016/j.biomaterials.2003.08.066 ↗
3. Barralet JE, Tremayne M, Lilley KJ, Gbureck U. Modification of calcium phosphate cement with α-hydroxy acids and their salts. Chem Mater. 2005;17:1313–9.10.1021/cm048803z ↗
4. Miyamoto Y, Ishikawa K, Takechi M, Toh T, Yuasa T, Nagayama M, Suzuki K. Histological and compositional evaluations of three types of calcium phosphate cements when implanted in subcutaneous tissue immediately after mixing. J Biomed Mater Res Appl Biomater. 1999;48:36–42.10.1002/(SICI)1097-4636(1999)48:1<36::AID-JBM8>3.0.CO;2-I ↗
5. LeGeros RZ, Chohayeb A, Shulman A. Apatitic calcium phosphates: possible dental restorative materials. J Dent Res. 1982;61:343.
6. Brown WE, Chow LC. A new calcium phosphate setting cement. J Dent Res. 1983;62:672.
7. Brown WE, Chow LC. Dental restorative cement pastes. US Patent No. US4518430; 1985.
8. Apelt D, Theiss F, El-Warrak AO, Zlinszky K, Bettschart-Wolfisberger R, Bohner M, Matter S, Auer JA, von Rechenberg B. In vivo behavior of three different injectable hydraulic calcium phosphate cements. Biomaterials. 2004;25:1439–51.10.1016/j.biomaterials.2003.08.073 ↗
9. Mirtchi AA, Lemaitre J, Terao N. Calcium phosphate cements: study of the β-tricalcium phosphate–monocalcium phosphate system. Biomaterials. 1989;10:475–80.10.1016/0142-9612(89)90089-6 ↗
10. Bohner M, Lemaitre J, Ring TA. Effects of sulfate, pyrophosphate, and citrate ions on the physicochemical properties of cements made of β-tricalcium phosphate-phosphoric acid-water mixtures. J Am Ceram Soc. 1996;79:1427–34.10.1111/j.1151-2916.1996.tb08746.x ↗
11. Barralet JE, Grover LM, Gbureck U. Ionic modification of calcium phosphate cement viscosity. Part II: hypodermic injection and strength improvement of brushite cement. Biomaterials. 2004;25:2197–203.10.1016/j.biomaterials.2003.09.085 ↗
12. Aizawa M, Haruta Y, Okada I. Development of novel cement processing using hydroxyapatite particles modified with inositol phosphate. Arch Bioceram Res. 2003;3:134–8.
13. Horiguchi Y, Yoshikawa A, Oribe K, Aizawa M. Fabrication of chelate-setting hydroxyapatite cements from four kinds of commercially-available powder with various shape and crystallinity and their mechanical property. J Ceram Soc Jpn. 2008;116:50–5.10.2109/jcersj2.116.50 ↗
14. Konishi T, Horiguchi Y, Mizumoto M, Honda M, Oribe K, Morisue H, Ishii K, Toyama Y, Matsumoto M, Aizawa M. Novel chelate-setting calcium-phosphate cements fabricated with wet-synthesized hydroxyapatite powder. J Mater Sci Mater Med. 2012. doi: 10.1007%2Fs10856-012-4834-9 .
15. Dao TH. Polyvalent cation effects on myo-inositol hexakis dihydrogenphosphate enzymatic dephosphorylation in dairy wastewater. J Environ Qual. 2003;32:694–701.10.2134/jeq2003.6940 ↗
16. Elliott JC. Structure and chemistry of the apatites and other calcium orthophosphates. 1st ed. Amsterdam: Elsevier; 1994.
17. Takahashi S, Konishi T, Nishiyama K, Mizumoto M, Honda M, Horiguchi Y, Oribe K, Aizawa M. Fabrication of novel bioresorbable β-tricalcium phosphate cement on the basis of chelate-setting mechanism of inositol phosphate and its evaluation. J Ceram Soc Jpn. 2011;119:35–42.10.2109/jcersj2.119.35 ↗
18. Nishiyama K, Takahashi S, Mizumoto M, Oribe K, Matsumoto M, Morisue H, Toyama Y, Aizawa M. In vitro and in vivo evaluations of chelate-setting β-tricalcium phosphate cements using inositol phosphate. Proc Bioceram. 2009;22:871–4.
19. Konishi T, Takahashi S, Mizumoto M, Honda M, Oribe K, Aizawa M. Effect of the addition of various polysaccharides on the material properties and cytotoxicity of chelate-setting β-tricalcium phosphate cement. Phosphorus Res Bull. 2012;26:59–64.10.3363/prb.26.59 ↗
20. Konishi T, Zhuang Z, Mizumoto M, Honda M, Aizawa M. Fabrication of chelate-setting cement from hydroxyapatite powder prepared by simultaneously grinding and surface-modifying with sodium inositol hexaphosphate and their material properties. J Ceram Soc Jpn. 2012;120:1–7.10.2109/jcersj2.120.159 ↗
21. Sudo H, Kodama H, Amagai Y, Yamamoto S, Kasai S. In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J Cell Biol. 1983;96:191–8.10.1083/jcb.96.1.191 ↗
22. Gbureck U, Grolms O, Barralet JE, Grover LM, Thull R. Mechanical activation and cement formation of β-tricalcium phosphate. Biomaterials. 2003;24:4123–31.10.1016/S0142-9612(03)00283-7 ↗
23. Gbureck U, Barralet JE, Thull R. Thermodynamic study of formation of amorphous β-tricalcium phosphate for calcium phosphate cements. Key Eng Mater. 2004;254–256:249–52.10.4028/www.scientific.net/KEM.254-256.249 ↗
24. Kaneno M, Sakamoto K, Yamaguchi S, Suganuma K. Formation of hydroxyapatite from mechanochemically treated β-tricalcium bis(orthophosphate). Key Eng Mater. 2006;317–318:781–4.10.4028/www.scientific.net/KEM.317-318.781 ↗
25. Sakamoto K, Yamaguchi S, Fujihara I, Satoh K, Tsunawaki Y. Hardening of β-tricalcium phosphate mechanically treated by morter grinder. Phosphorus Res Bull. 2011;25:64–7.10.3363/prb.25.64 ↗
26. Martin CJ, Evans WJ. Phytic acid-metal ion interactions. II. The effect of pH on Ca(II) binding. J Inorg Biochem. 1986;27:17–30.10.1016/0162-0134(86)80105-2 ↗
27. Luttrell BM. The biological relevance of the binding of calcium ions by inositol phosphates. J Biol Chem. 1993;268:1521–4.10.1016/S0021-9258(18)53883-7 ↗
28. Fernández E, Boltong MG, Ginebra MP, Bermúdez O, Driessens FCM, Planell JA. Common ion effect on some calcium phosphate cements. Clin Mater. 1994;16:99–103.10.1016/0267-6605(94)90103-1 ↗
29. Ishikawa K, Asaoka K. Estimation of ideal mechanical strength and critical porosity of calcium phosphate cement. J Biomed Mater Res. 1995;29:1537–43.10.1002/jbm.820291210 ↗
30. Barralet JE, Gaunt T, Wright AJ, Gibson IR, Knowles JC. Effect of porosity reduction by compaction on compressive strength and microstructure of calcium phosphate cement. J Biomed Mater Res. 2002;63:1–9.10.1002/jbm.1074 ↗
31. Suzuki T, Ohashi R, Yokogawa Y, Nishizawa K, Nagata F, Kawamoto Y, Kameyama T, Toriyama M. Initial anchoring and proliferation of fibroblast L-929 cells on unstable surface of calcium phosphate ceramics. J Biosci Bioeng. 1999;87:320–7.10.1016/S1389-1723(99)80039-5 ↗
32. Deligianni DD, Katsala ND, Koutsoukos PG, Missirlis YF. Effect of surface roughness of hydroxyapatite on human bone marrow cell adhesion, proliferation, differentiation and detachment strength. Biomaterials. 2001;22:87–96.10.1016/S0142-9612(00)00174-5 ↗
33. Wiltfang J, Merten HA, Schlegel KA, Schultze-Mosgau S, Kloss FR, Rupprecht S, Kessler P. Degradation characteristics of α and β tri-calcium-phosphate (TCP) in minipigs. J Biomed Mater Res. 2002;63:115–21.10.1002/jbm.10084 ↗
34. Zerbo IR, Bronckers AL, de Lange G, Burger EH. Localisation of osteogenic and osteoclastic cells in porous β-tricalcium phosphate particles used for human maxillary sinus floor elevation. Biomaterials. 2005;26:1445–51.10.1016/j.biomaterials.2004.05.003 ↗
35. Sun J, Shen QY, Lu JX. Comparative study of microstructural remodification to porous β-TCP and HA in rabbits. Chinese Sci Bull. 2009;54:2962–7.10.1007/s11434-009-0332-y ↗
36. Ohura K, Bohner M, Hardouin P, Lemaitre J, Pasquier G, Flautre B. Resorption of, and bone formation from, new β-tricalcium phosphate-monocalcium phosphate cements: An in vivo study. J Biomed Mater Res. 1996;30:192–200.10.1002/(SICI)1097-4636(199602)30:2<193::AID-JBM9>3.0.CO;2-M ↗
37. Theiss F, Apelt D, Brand B, Kutter A, Zlinszky K, Bohner M, Matter S, Frei C, Auer JA, von Rechenberg B. Biocompatibility and resorption of a brushite calcium phosphate cement. Biomaterials. 2005;26:4383–94.10.1016/j.biomaterials.2004.11.056 ↗
38. Ducheyne P, Radin S, King L. The effect of calcium phosphate ceramic composition and structure on in vitro behavior. I. Dissolution. J Biomed Mater Res. 1993;27:25–34.10.1002/jbm.820270105 ↗