Bionic Research on Multistage Pain Sensitization Based on Ionic Oxide Transistor Array
Source abstract
Abstract
Multistage pain perception is of great significance for surviving the outside harmful stimuli for organisms.In this work, using a sodium alginate biopolymer electrolyte as neurotransmitter layer, a 5×5 array of junctionless transistoris successfully fabricated for pain perception.The device operates well at low voltage (2 V) with a large current on-off ratio (>10 4 ) and on-state current (>10 μA).This coplanar-gate array can not only emulate the important functions of synapses, such as excitatory postsynaptic current, paired-pulse facilitation, and dynamic filtering, but also successfully mimic pain-perception and sensitization abilities of the artificial nociceptor network.Furthermore, this work also successfully emulates the multistage spatio-temporal sensitization in the nociceptor network.Construction of this kind of network system provides a new way for the application of the next-generation neuromorphic brain-like system.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Neuroscience and Neural Engineering · Advanced Memory and Neural Computing · Diamond and Carbon-based Materials Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (35)
Show source-provided references
1. BASBAUM A I, BAUTISTA D M, SCHERRER G, et al. Cellular and molecular mechanisms of pain. Cell, 2009, 139(2):267.10.1016/j.cell.2009.09.028 ↗
2. CORTELLI P, GIANNINI G, FAVONI V, et al. Nociception and autonomic nervous system. Neurological Sciences, 2013, 34(1):41.10.1007/s10072-013-1391-z ↗
3. RAJA S N, CARR D B, COHEN M, et al. The revised international association for the study of pain definition of pain: concepts, challenges, and compromises. Pain, 2020, 161(9): 1976.10.1097/j.pain.0000000000001939 ↗
4. TRACEY J R, DANIEL W. Nociception. Current Biology, 2017, 27(4):129.10.1016/j.cub.2017.01.037 ↗
5. LI Y, YIN K, JIANG J, et al. A biopolymer-gated ionotronicjunctionless oxide transistor array for spatiotemporal pain-perception emulation in nociceptor network. Nanoscale, 2022, 14(6):2316.10.1039/D1NR07896H ↗
6. LI F, GAO S, LU Y, et al. Bio-inspired multi-mode pain-perceptual system (MMPPS) with noxious stimuli warning, damage localization, and enhanced damage protection. Advanced Science, 2021, 8(10):2004208.10.1002/advs.202004208 ↗
7. LU Q, SUN F, LIU L, et al. Bio-inspired flexible artificial synapses for pain perception and nerve injuries. npj Flexible Electronics, 2020, 4: 3.10.1038/s41528-020-0066-0 ↗
8. KUMAR M, KIM H S, KIM J. A highly transparent artificial photonic nociceptor. Advanced Materials, 2019, 31(19):e1900021.10.1002/adma.201900021 ↗
9. GE J, ZHANG S, LIU Z, et al. Flexible artificial nociceptor using a biopolymer-based forming-free memristor. Nanoscale, 2019, 11(14):6591.10.1039/C8NR08721K ↗
10. WANG C, LIANG S, WANG S, et al. Gate-tunable van der waals heterostructure for reconfigurable neural network vision sensor. Science Advances, 2020, 6(26):eaba6173.10.1126/sciadv.aba6173 ↗
11. CHEN Y, SHU Z, ZHANG S, et al. Sub-10 nm fabrication: methods and applications. International Journal of Extreme Manufacturing, 2021, 3(3):032002.10.1088/2631-7990/ac087c ↗
12. XIE D, YIN K, JANG J, et al. Polarization-perceptual anisotropic two-dimensional ReS2 neuro-transistor with reconfigurable neuromorphic vision. Materials Horizons, 2022, 9(5):1448.10.1039/D1MH02036F ↗
13. YUKIHIRO K, YU N, MICHIHITO U. Ferroelectric artificial synapses for recognition of a multishaded image. IEEE Transactions on Electron Devices, 2014, 61(8):2827.10.1109/TED.2014.2331707 ↗
14. JIANG J, GUO J, WAN X, et al. 2D MoS2 neuromorphic devices for brain-like computational systems. Small, 2017, 13(29):1700933.10.1002/smll.201700933 ↗
15. JANG J, HU W, XIE D, et al. 2D electric-double-layer phototransistor for photoelectronic and spatiotemporal hybrid neuromorphic integration. Nanoscale, 2019, 11(3):1360.10.1039/C8NR07133K ↗
16. LUO C, KUNER T, KUNER R. Synaptic plasticity in pathological pain. Trends in Neurosciences, 2014, 37(6):343.10.1016/j.tins.2014.04.002 ↗
17. CHANG Y, SHAN K, XU Y, et al. Hardware implementation of photoelectrically modulated dendritic arithmetic and spike-timing-dependent plasticity enabled by an ion-coupling gate-tunable vertical 0D-perovskite/2D-MoS2 hybrid-dimensional van der Waals heterostructure. Nanoscale, 2020, 12(42):21798.10.1039/D0NR04950F ↗
18. WANG Y Q, WANG J, XIA S H, et al. Neuropathic pain generates silent synapses in thalamic projection to anterior cingulate cortex. Pain, 2021, 162(5):1322.10.1097/j.pain.0000000000002149 ↗
19. HU W, JIANG J, XIE D, et al. Proton-electron-coupled MoS2 synaptic transistors with a natural renewable biopolymer neurotransmitter for brain-inspired neuromorphic learning. Journal of Materials Chemistry C, 2019, 7(3):682.10.1039/C8TC04740E ↗
20. XIE D, JING J, HU W, et al. Coplanar multigate MoS2 electric-double-layer transistors for neuromorphic visual recognition. ACS Appled Materials Interfaces, 2018, 10(31):25943.10.1021/acsami.8b07234 ↗
21. CITRI A, MALENKA R C. Synaptic plasticity: multiple forms, functions, and mechanisms. Neuropsychopharmacology, 2008, 33(1):18.10.1038/sj.npp.1301559 ↗
22. FENG G, JIANG J, ZHAO Y, et al. A sub-10 nm vertical organic/ inorganic hybrid transistor for pain-perceptual and sensitization-regulated nociceptor emulation. Advanced Materials, 2020, 32(6):1906171.10.1002/adma.201906171 ↗
23. GOLD M S, GEBHART G F. Nociceptor sensitization in pain pathogenesis. Nature Medicine, 2010, 16(11):1248.10.1038/nm.2235 ↗
24. JIANG S, HE Y, LIU R, et al. Freestanding dual-gate oxide-based neuromorphic transistors for flexible artificial nociceptors. IEEE Transactions on Electron Devices, 2021, 68(1):415.10.1109/TED.2020.3039762 ↗
25. FENG G, JIANG J, LI Y, et al. Flexible vertical photogating transistor network with an ultrashort channel for in‐sensor visual nociceptor. Advanced Functional Materials, 2021, 31(36):2104327.10.1002/adfm.202104327 ↗
26. FORTUNATO E, BARQUINHA P, MARTINS R. Oxide semiconductor thin-film transistors: a review of recent advances. Advanced Materials, 2012, 24(22):2945.10.1002/adma.201103228 ↗
27. DENG X, WANG S Q, LIU Y X, et al. A flexible mott synaptic transistor for nociceptor simulation and neuromorphic computing. Advanced Functional Materials, 2021, 31(23):2101099.10.1002/adfm.202101099 ↗
28. BARON R, MAIER C, ATTAL N, et al. Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles. Pain, 2017, 158(2):261.10.1097/j.pain.0000000000000753 ↗
29. GU L, LI Y, XIE D, et al. Fully Optical-driving ionotronic InGaZnO4 phototransistor for gate-tunable bidirectional photofiltering and visual perception. IEEE Transactions on Electron Devices, 2022, 69(8):4382.10.1109/TED.2022.3185954 ↗
30. LI M, YANG F S, HSU H C, et al. Defect engineering in ambipolar layered materials for mode-regulable nociceptor. Advanced Functional Materials, 2020, 31(5):2007587.10.1002/adfm.202007587 ↗
31. VERRIPTIS M, CHANG P, FITZGERALD M, et al. The development of the nociceptive brain. Neuroscience, 2016, 338(3):207.10.1016/j.neuroscience.2016.07.026 ↗
32. XIE D, JIANG J, DING L. Anisotropic 2D materials for post-Moore photoelectric devices. Journal of Semiconductors, 2022, 43(1):010201.10.1088/1674-4926/43/1/010201 ↗
33. LI Q, TAO Q, CHE Y, et al. Low voltage and robust InSe memristor using van der Waals electrodes integration. International Journal of Extreme Manufacturing, 2021, 3(4):045103.10.1088/2631-7990/ac2296 ↗
34. ZHAO Y, LIU W, ZHAO J, et al. The fabrication, characterization and functionalization in molecular electronics. International Journal of Extreme Manufacturing, 2022, 4(2):022003.10.1088/2631-7990/ac5f78 ↗
35. LI G XIE, D, ZHONG H, et al. Photo-induced non-volatile VO2 phase transition for neuromorphic ultraviolet sensors. Nature Communications, 2022, 13: 1729.10.1038/s41467-022-29456-5 ↗