Advances and Challenges in Tissue Engineering: Biomaterials, Cellular Strategies, and Clinical Applications
Source abstract
Abstract
Tissue engineering integrates concepts from medicine, biology, and engineering to create living constructs capable of repairing, replacing, or supporting damaged tissues. This multidisciplinary field relies on the interplay between biomaterials, cellular sources, and bioactive signaling to achieve functional tissue regeneration. This review provides a comprehensive overview of recent advances in scaffold design, highlighting natural, synthetic, and hybrid materials, as well as innovative fabrication techniques such as electrospinning, 3D bioprinting, and smart biomaterials. It discusses the role of stem cells and growth factors in directing regeneration and examines a wide range of clinical applications, including skin regeneration, cartilage repair, bone tissue engineering, dental and periodontal regeneration, nerve repair, cardiac tissue engineering, liver tissue models, and ophthalmic applications. Current challenges, such as immune responses, limited vascularization, scalability, and regulatory barriers, are addressed alongside emerging strategies aimed at improving clinical translation. By integrating diverse tissue types and engineering approaches within a unified framework, this review offers a broad yet detailed perspective on the current state and future directions of regenerative medicine.
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Research context
OpenAlex topics: Tissue Engineering and Regenerative Medicine · 3D Printing in Biomedical Research · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Health Services Research and Management, School of Health and Psychological Sciences, City, University of London, London WC1E 7HU, UK
Department of Bioscience Research, Bioscience Research Centre, College of Dentistry, University of Tennessee Health Science Centre, 875 Union Avenue, Memphis, TN 38163, USA
Dental School, University of Greater Manchester, Bolton BL3 5AB, UK
Faculty of Dentistry, University of Puthisastra, Phnom Penh 12211, Cambodia
Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy
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