JOURNAL OF FUNCTIONAL BIOMATERIALS

Alexandru Mihai Micu, Robert Mihai Bacalu, Teodor Raul Constantin, Alexia-Ecaterina Cârstea et al.

Conventional typodonts for preclinical operative dentistry are idealised and lack the variability and tactile feedback of natural teeth; virtual-reality and haptic simulators remain costly for large cohorts. This study developed a reproducible, low-cost digital workflow for patient-specific, multi-material 3D-printed dental simulators and evaluated the models from a learner’s p…

Zahra Khaleghi Moghadam, Mohammad Nourany, Saadi Hosseini, Naser Farokhi et al.

Current bone regeneration strategies face significant constraints, relying either on synthetic scaffolds with slow degradation that require biochemical supplements or on bioactive fillers. Recently, the focus has shifted towards functional natural biomaterials with inherent osteoinductive potential. This study presents a promising candidate based on a silica-containing plant-de…

Abdulrahman Alblowi, Siyu Lin, Olivier Bouchot, Jeremy Lagrange et al.

Background: Energy dissipation reflects the viscoelastic behavior of biological tissues and plays a key role in arterial elastic recoil and diastolic flow support. In the native aorta, efficient storage and release of mechanical energy are essential for maintaining ventriculo–aortic coupling. The energy dissipation ratio (EDR) quantifies the proportion of mechanical energy lost…

Mahmoud Elsaafin, Alexandra Mihaela Stoica, Marius Mariș, Adina Simona Coșarcă et al.

Background: Palatal orthodontic mini-implants are increasingly used for sagittal, vertical, and transverse mechanics, including molar distalization, mesialization, posterior intrusion, impacted tooth traction, and miniscrew-assisted rapid palatal expansion. Yet site selection is often discussed as if anatomical bone availability were the dominant determinant of performance. Obj…

Antonio V. Vega, Arnold Solano, Fausto Acosta-Fiallos, Raúl Dávalos Monteiro

The corrosion of metallic biomaterials under physiological conditions remains a critical challenge due to the risk of ion release affecting biocompatibility. In this study, the time-dependent electrochemical behavior of a poly(vinyl alcohol) (PVA)/chitosan biopolymer coating applied to biomedical-grade steel was evaluated to assess its protective performance. The coating was pr…

Kang-Il Kim, Gi-Young Jang, Kye-Youl Cho, Myung-Seo Kim et al.

When delivered intravenously, mesenchymal stem cells (MSCs) enhance fracture healing and can be injected at various time points, but the optimal timing remains unclear. This study aimed to clarify the optimal timing of MSC delivery to enhance the healing. For-ty-nine Wistar rats with femoral shaft fractures were randomized according to injection timing: immediately after fractu…

Micaela Berni, Laura Caliogna, Elisa Lenta, Gloria Acquafredda et al.

This in vitro study investigates the effects of therapeutic magnetic resonance (TMR®), a novel biophysical stimulation technology, on mesenchymal stromal cells (MSCs) to support its potential application in regenerative medicine. The role of pulsed electromagnetic fields in bone healing is already established. We evaluated whether TMR® influences MSC proliferation, differentiat…

Valerie Lankes, Andrea Coldea, John Meinen, Bogna Stawarczyk

This study investigated the effects of airborne-particle abrasion angle and nozzle geometry on the surface free energy (SFE), surface roughness (Ra), and flexural strength (FS) of a feldspar ceramic. A total of 70 feldspar ceramic substrates were assigned to seven groups (n = 10). Six groups were air-abraded with 50 µm Al2O3 at 0.05 MPa for 10 s using a conventional nozzle at 2…

Chloé Duchatelle, Rosana Costa, Ana Sofia Vinhas, Filomena Salazar et al.

Based on the growing use of guided bone regeneration (GBR) for implant rehabilitation in atrophic alveolar ridges, the choice of barrier membrane remains a critical factor for clinical success. This review aimed to evaluate the clinical effectiveness of titanium-reinforced dense polytetrafluoroethylene (d-PTFE-Ti) membranes compared with resorbable collagen membranes in vertica…

André F. V. Pedroso, Luciana Silva, Marta L. S. Barbosa, Wenfeng Ding et al.

Additive manufacturing (AM) has expanded the design space of biomaterials for biomedical engineering, enabling patient-specific geometries, controlled porosity, multi-material constructs and cell-compatible fabrication. However, clinical translation remains constrained by a mismatch between fabrication capability and biological, mechanical and regulatory performance. Unlike rev…

Mhd Kher Alsaeyd Ahmad, Doina Chioran, Dana-Emanuela Pitic (Coţ), Elena-Alina Moacă et al.

Background/Objectives: Plant-mediated silver nanoparticles (AgNPs) are promising components for oral biomaterials because of their antimicrobial potential; however, their biological behavior depends strongly on the phytochemical matrix, physicochemical characteristics, and exposure concentration. This study aimed to evaluate silver nanoparticles formulations synthesized using t…

Mehmet Ates, Ceyda Akin

This study evaluated the biomechanical performance of different abutment types, superstructure materials, prosthetic designs, and loading conditions in the implant-supported rehabilitation of three consecutive missing teeth in the mandibular posterior region using three-dimensional finite element analysis (3D-FEA). Twenty FEA models were constructed, simulating two-implant (pon…

Bára Frýdlová, Nikola Slepičková Kasálková, Irena Vacková, Šimon Pražák et al.

This study aims to construct patterns with defined shapes on perfluoroethylene propylene (FEP) via a replication process that has potential applications in tissue engineering. Our focus was on creating ripple periodic submicron-scale structures and subsequently activating them with argon plasma. Plasma activation of the replicated pattern on FEP substrates proved to be an effec…

Zubair Ahmed, Huiliang Cao

Fibrinogen adsorption governs biological responses to implantable medical devices; however, surface properties influence the overall functionality of the biomaterial, and guided fibrinogen adsorption remains limited. In the present work, CaCO3 was electrochemically deposited on commercial Ti at −1.6 V for 1 h, 2 h, and 3 h. Furthermore, the effects on fibrinogen adsorption were…

Zainab Alknery, Ali Arab

The current study investigates the mechanical performance of the hollow cylindrical scaffolds with varying inner radii designed for bone tissue engineering. The biomimetic Voronoi-based structures with distinct inner diameters were manufactured using the stereolithography (SLA) technique and eco-friendly plant-based resin. The experimental results revealed that increasing the i…

Agnes E. Terek, John T. Walker, Gillian I. Bell, John A. Ronald et al.

Cellular therapies harnessing the potential of endothelial colony-forming cells (ECFCs) for therapeutic revascularization in patients with critical limb ischemia (CLI) have garnered much interest. However, limited cell persistence following intramuscular injection into ischemic tissues has prompted the development of biomaterials as cell-delivery platforms to support cell survi…

Kacper Wiertelak-Makała, Joanna Nowak, Agata Szczesio-Włodarczyk, Piotr Wysocki et al.

While resin-based dental composites (RBCs) are widely recognized as the golden standard in restorative dentistry, there is a need for improvement in their properties, including their potential biofunctional behavior. The aim of this study was to assess the impact of hydroxyapatite (HA) filler on the mechanical properties and provide preliminary evidence of biofunctional potenti…

Quang Thai Vu, Hoang Ngan Nguyen, Thi Xoan Le, Thi Thuy Trang Do et al.

Background/Objectives: This study evaluated the hemostatic efficacy of a chitosan-based field hemostatic sponge (FHS), the first hemostatic product of this type manufactured in Vietnam, across bleeding models of varying injury severity under both normal physiological conditions and after aspirin administration. Methods: An in vivo experimental study was conducted using two mode…

Su Yeon Noh, Jee Hyun Kang, In Gyu Yang, Min Young Jeong et al.

Intratympanic (IT) injection of corticosteroids is a standard clinical treatment for sensorineural hearing loss; however, achieving both biocompatibility and efficient cochlea drug delivery remains a significant challenge. Herein, we engineered a novel drug nanocrystal (NS)-loaded thermo-reversible hydrogel (NS-TG) system of dexamethasone-21-palmitate (DEX-P), a lipophilic prod…

Rald V. M. Groven, Changlin Qi, Philipp Schräder, Deniz D. Özman et al.

Metal alloys in arthroplasty face limitations including aseptic loosening, material failure, and allergic reactions. High-performance oxide ceramics (HPOCs) represent an alternative but are bioinert, restricting osseointegration and osteoconduction. The aim of this study was to convert bioinert HPOC surfaces into bioactive osteogenic microenvironments through stable peptide-bio…