Cuttlefish Bone-Derived Calcium Phosphate Bioceramics Have Enhanced Osteogenic Properties
Source abstract
Abstract
Cuttlefish bones are byproducts of cuttlefish processing and are readily available in the marine food industry. In this study, calcium phosphate bioceramics were prepared from cuttlefish bones using a two-stage hydrothermal calcination process. The results indicated that all bioceramics derived from cuttlefish bones had a higher degradation capacity, better bone-like apatite formation ability, and higher degree of osteogenic differentiation than commercially available hydroxyapatite. Notably, β-tricalcium phosphate, which had the highest degree of Ca2+ and Sr2+ dissolution among the bioceramics extracted, can significantly upregulate osteogenic markers (alkaline phosphatase, osteocalcin) and stimulate bone matrix mineralization. Thus, it is a promising bioceramic material for applications in bone regeneration.
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Research context
OpenAlex topics: Bone Tissue Engineering Materials · Endodontics and Root Canal Treatments · Dental Implant Techniques and Outcomes
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou 570228, China
Institute of Orthopaedic & Musculoskeletal Science, University College London, Royal National Orthopaedic Hospital, London HA7 4LP, UK
Funding
International Science & Technology Cooperation Program of Hainan Province · Engineering and Physical Sciences Research Council via DTP CASE Programme · Medical Research Council through MRC-UCL Therapeutic Acceleration Support (TAS) Fund · National Institute for Health and Care Research through UCLH BRC-UCL Therapeutic Acceleration Support (TAS) Fund
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