Bisphenol A Release from Fiber-Reinforced vs. Conventional Stainless-Steel Fixed Retainers: An In Vitro Study
Source abstract
Abstract
Objectives: The objectives of this study were to investigate in vitro BPA release from two common fiberglass fixed lingual canine-to-canine retainers and to compare these amounts with those released from a conventional multistranded stainless-steel orthodontic retainer. Methods: Fifty-four recently extracted teeth were divided into groups of six teeth each, formed in an arch shape. Three different retainer types were evaluated: Ribbond, EverStick Ortho and Wildcut wire. Three identical specimens were constructed for each retainer type. BPA release was determined with validated the liquid chromatography–tandem mass spectrometry method at 1 and 24 h, as well as at 7, 14 and 30 days. The method’s limits of detection and quantification were 0.32 ng/mL and 0.96 ng/mL, respectively. A two-way mixed, repeated-measures analysis of variance with Greenhouse–Geisser correction was employed to verify the existence of any significant differences. Results: Higher levels of BPA were released from the polyethylene fiber and glass fiber retainer in comparison with the conventional retainer in the present study. The differences between the systems over time were not statistically significant at the 95% confidence level. Conclusions: In vitro BPA release during the first month did not differ between the examined retainer types. The highest BPA concentrations were observed at 1 month.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Effects and risks of endocrine disrupting chemicals · Dental materials and restorations · Orthodontics and Dentofacial Orthopedics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece
Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece
References (43)
Show source-provided references
1. European Food Safety Authority (2007). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the commission related to Lutein for use in particular nutritional uses. EFSA J., 5, 1–75.10.2903/j.efsa.2007.315 ↗
2. Cimmino, I., Fiory, F., Perruolo, G., Miele, C., Beguinot, F., Formisano, P., and Oriente, F. (2020). Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease. Int. J. Mol. Sci., 21.10.3390/ijms21165761 ↗
3. Release and toxicity of bisphenol-A (BPA) contained in orthodontic adhesives: A systematic review10.1016/j.ortho.2020.11.002 ↗
4. Release of bisphenol-A from a light-cured adhesive bonded to lingual fixed retainers10.1016/j.ajodo.2009.12.026 ↗
5. An investigation into bisphenol A leaching from materials used intraorally10.1016/j.adaj.2016.01.013 ↗
6. Aungst, J., Lin, F.S., and Keefe, D.M. (Dep. Health Hum. Serv. Food Drug Adm., 2014). Updated safety assessment of Bisphenol A (BPA) for use in food contact applications, Dep. Health Hum. Serv. Food Drug Adm., Memorandum.
7. EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Lambré, C., Barat Baviera, J.M., Bolognesi, C., Chesson, A., Cocconcelli, P.S., Crebelli, R., Gott, D.M., Grob, K., and Lampi, E. (2021). Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs. EFSA J., 21, e06857.
8. Paula, A.B., Toste, D., Marinho, A., Amaro, I., Marto, C.-M., Coelho, A., Marques-Ferreira, M., and Carrilho, E. (2019). Once resin composites and dental sealants release bisphenol-a, how might this affect our clinical management?—A systematic review. Int. J. Environ. Res. Public Health, 16.10.3390/ijerph16091627 ↗
9. Impact of Bisphenol A and its alternatives on oocyte health: A scoping review10.1093/humupd/dmae025 ↗
10. A systematic study of the release of bisphenol A by orthodontic materials and its biological effects
11. A Systematic Review of Exposure to Bisphenol A from Dental Treatment
12. An integrative review on the toxicity of Bisphenol A (BPA) released from resin composites used in dentistry10.1002/jbm.b.34843 ↗
13. Bisphenol A release from an orthodontic resin composite: A GC/MS and LC/MS study10.1016/j.dental.2017.11.018 ↗
14. Release of monomers from orthodontic adhesives10.1016/j.ajodo.2016.02.027 ↗
15. Bisphenol-A and residual monomer leaching from orthodontic adhesive resins and polycarbonate brackets: A systematic review10.1016/j.ajodo.2012.11.015 ↗
16. A systematic review of biocompatibility and safety of orthodontic clear aligners and transparent vacuum-formed thermoplastic retainers: Bisphenol-A release, adverse effects, cytotoxicity, and estrogenic effects10.4103/1735-3327.372658 ↗
17. Evaluation of bisphenol release of different clear aligner materials using the liquid chromatography-mass spectrometry/mass spectrometry method10.2319/010923-17.1 ↗
18. Iliadi, A., Koletsi, D., Papageorgiou, S.N., and Eliades, T. (2020). Safety considerations for thermoplastic-type appliances used as or-thodontic aligners or retainers. a systematic review and meta-analysis of clinical and in-vitro research. Materials, 13.10.3390/ma13081843 ↗
19. Cytotoxicity evaluation of dental and or-thodontic light-cured composite resins10.1002/cre2.337 ↗
20. An investigation into bisphenol-A leaching from orthodontic materials10.2319/081413-600.1 ↗
21. Bisphenol A as degradation product of monomers used in resin-based dental materials10.1016/j.dental.2021.03.005 ↗
22. Bisphenol A release from orthodontic adhesives and its correlation with the degree of conversion10.1016/j.ajodo.2014.09.013 ↗
23. Meta-analytical analysis on components released from resin-based dental materials10.1007/s00784-022-04625-4 ↗
24. Katsaros, C., and Eliades, T. (2023). Release of Bisphenol-A from materials used for fixed retainer bonding. Ch. 11. Debonding and Fixed Retention in Orthodontics: An Evidence Based Clinical Guide, John Wiley & Sons, Ltd.. [1st ed.].
25. Bisphenol A release from orthodontic adhesives measured in vitro and in vivo with gas chromatography10.1016/j.ajodo.2016.07.019 ↗
26. Monomer release from orthodontic retentions: An in vitro study10.1016/j.ajodo.2017.06.021 ↗
27. Release of bisphenol A from resin composite used to bond orthodontic lingual retainers10.1016/j.ajodo.2011.04.022 ↗
28. Comparative evaluation of salivary bisphenol A levels in patients wearing vacuum-formed and Hawley retainers: An in-vivo study10.1016/j.ajodo.2016.07.022 ↗
29. Fatigue resistance, debonding force, and failure type of fiber-reinforced composite, polyethylene ribbon-reinforced, and braided stainless steel wire lingual retainers in vitro10.4041/kjod.2013.43.4.186 ↗
30. Comparative evaluation between glass and polyethylene fiber reinforced composites: A review of the current literature
31. Adverse reactions to orthodontic materials10.1111/adj.12473 ↗
32. Simultaneous determination of bisphenol A and its chlorinated derivatives in human plasma: Development, validation and application of a UHPLC-MS/MS method10.1016/j.chemosphere.2019.125236 ↗
33. (2012). Biological Evaluation of Medical Devices—Part 12: Sample Preparation and Reference Materials (Standard No. ISO 10993-12:2012).
34. Materials Preparation10.1016/S0080-8784(08)60069-1 ↗
35. Hampe, T., Wiessner, A., Frauendorf, H., Alhussein, M., Karlovsky, P., Bürgers, R., and Krohn, S. (2022). Monomer Release from Dental Resins: The Current Status on Study Setup, Detection and Quantification for In Vitro Testing. Polymers, 14.10.3390/polym14091790 ↗
36. Bisphenol-A release from thermoplastic clear aligner materials: A systematic review10.1177/14653125231160570 ↗
37. Biological significance of long-term bisphenol A release in the saliva of patients wearing orthodontic appliances: A systematic review and meta-analysis
38. Release of bisphenol A and its derivatives from orthodontic adhesive systems available on the European market as a potential health risk factor10.5604/12321966.1141390 ↗
39. Effects of Tooth Brushing and MouthWashing on Leaching Bisphenol A Levels From an Orthodontic Adhesive: An In Vitro Study10.5152/TurkJOrthod.2021.21176 ↗
40. BPA qualtitative and quantitative assessment associated with orthodontic bonding in vivo10.1016/j.dental.2015.04.020 ↗
41. High-performance liquid chromatography analysis of salivary bisphenol A levels from light-cured and chemically cured orthodontic adhesives10.1016/j.ajodo.2018.02.008 ↗
42. Hassan, R., Khan, M.U.A., Abdullah, A.M., and Razak, S.I.A. (2021). A Review on Current Trends of Polymers in Orthodontics: BPA-Free and Smart Materials. Polymers, 13.10.3390/polym13091409 ↗
43. Development and testing of novel bisphenol A-free adhesives for lingual fixed retainer bonding10.1093/ejo/cjv090 ↗