Tissue Engineering of the Corneal Endothelium: A Review of Carrier Materials
Source abstract
Abstract
Functional impairment of the human corneal endothelium can lead to corneal blindness. In order to meet the high demand for transplants with an appropriate human corneal endothelial cell density as a prerequisite for corneal function, several tissue engineering techniques have been developed to generate transplantable endothelial cell sheets. These approaches range from the use of natural membranes, biological polymers and biosynthetic material compositions, to completely synthetic materials as matrices for corneal endothelial cell sheet generation. This review gives an overview about currently used materials for the generation of transplantable corneal endothelial cell sheets with a special focus on thermo-responsive polymer coatings.
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Research context
OpenAlex topics: Corneal Surgery and Treatments · Corneal surgery and disorders · Ocular Surface and Contact Lens
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials, Institute of Biofunctional Polymer Materials, Hohe Straße 6, Dresden 01069, Germany
Institute of Anatomy, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany
CRTD/DFG-Center for Regenerative Therapies Dresden—Cluster of Excellence, Fetscherstraße 105, Dresden 01307, Germany
Department of Ophthalmology, Klinikum Chemnitz gGmbH, Flemmingstraße 2, Chemnitz 09116, Germany
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