journal article·2023-06-29Open access

Understanding the Degradation of Core-Shell Nanogels Using Asymmetrical Flow Field Flow Fractionation

Edyta Niezabitowska, Dominic M. Gray, Eduardo Gallardo-Toledo, Andrew Owen, Steve P. Rannard, Tom O. McDonald

Abstract

Nanogels are candidates for biomedical applications, and core-shell nanogels offer the potential to tune thermoresponsive behaviour with the capacity for extensive degradation. These properties were achieved by the combination of a core of poly(N-isopropylmethacrylamide) and a shell of poly(N-isopropylacrylamide), both crosslinked with the degradable crosslinker N,N′-bis(acryloyl)cystamine. In this work, the degradation behaviour of these nanogels was characterised using asymmetric flow field flow fractionation coupled with multi-angle and dynamic light scattering. By monitoring the degradation products of the nanogels in real-time, it was possible to identify three distinct stages of degradation: nanogel swelling, nanogel fragmentation, and nanogel fragment degradation. The results indicate that the core-shell nanogels degrade slower than their non-core-shell counterparts, possibly due to a higher degree of self-crosslinking reactions occurring in the shell. The majority of the degradation products had molecule weights below 10 kDa, which suggests that they may be cleared through the kidneys. This study provides important insights into the design and characterisation of degradable nanogels for biomedical applications, highlighting the need for accurate characterisation techniques to measure the potential biological impact of nanogel degradation products.
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Research context

OpenAlex topics: Field-Flow Fractionation Techniques · Optimization and Mathematical Programming

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, UK

Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L3 5TR, UK

Centre of Excellence in Long-Acting Therapeutics (CELT), University of Liverpool, Liverpool L3 5TR, UK

Materials Innovation Factory, University of Liverpool, Liverpool L7 3NY, UK

Department of Materials, The University of Manchester, Oxford Road, Manchester M13 9PL, UK

Henry Royce Institute, The University of Manchester, Oxford Road, Manchester M13 9PL, UK

Funding

EPSRC

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