Osseointegration of Titanium Implants in Onlay of Cerament™, a New Ceramic Bone Substitute
Source abstract
Abstract
The purpose was to investigate whether a new biphasic and injectable ceramic bone substitute Cerament™ that rapidly remodels to bone, may contribute to the retention of titanium implant screws during the healing period, and to analyze the pattern of bone formation around titanium implants.Titanium screws were implanted in rat tibiae and embedded with or without Cerament™ on the cortical surface. Torsional resistance was measured after 1 day, and after 6 and 12 weeks. Implant areas without bone substitute were analyzed histologically for comparison. The torsional resistance increased over time as the screws were osseointegrated. There was no difference in resistance between screws embedded in the bone substitute and control screws. The bone apposition was more pronounced on the proximal side of the screw than on the distal side. Cerament™ is capable of conducting bone growth from a cortical bone surface. The newly formed bone in this application does not significantly add to the osseointegrative strength of the implant screw, as measured by torque resistance, during the first 12 weeks.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Dental Implant Techniques and Outcomes · Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Oral Pathology, Faculty of Odontology, Malmö University, Malmö SE-205 06, Sweden
Department of Orthopedics, Lund University Hospital, Lund SE-221 85, Sweden
References (28)
Show source-provided references
1. Anatomical aspects of sinus floor elevations10.1034/j.1600-0501.2000.011003256.x ↗
2. Sinus augmentation for dental implants: The use of autogenous bone10.1016/S0278-2391(97)90185-3 ↗
3. Morbidity at bone graft donor sites10.1097/00005131-198909000-00002 ↗
4. Autogenous iliac crest bone graft. Complications and functional assessment10.1097/00003086-199706000-00011 ↗
5. Prospective study on the augmentation of the maxillary sinus with calcium sulfate: Histological results10.1902/jop.2000.71.6.940 ↗
6. A 3-year prospective follow-up study of implant-supported fixed prostheses in patients subjected to maxillary sinus floor augmentation with a 80:20 mixture of deproteinized bovine bone and autogenous bone Clinical, radiographic and resonance frequency analysis10.1016/j.ijom.2004.09.009 ↗
7. Maxillary sinus floor grafting with beta-tricalcium phosphate in humans: Density and microarchitecture of the newly formed bone10.1111/j.1600-0501.2005.01166.x ↗
8. Esposito, M., Grusovin, M.G., Worthington, H.V., and Coulthard, P. (2006). Interventions for replacing missing teeth: Bone augmentation techniques for dental implant treatment. Cochrane Database Syst. Rev.10.1002/14651858.CD003607.pub2 ↗
9. Augmentation of anterior vertebral body screw fixation by an injectable, biodegradable calcium phosphate bone substitute10.1097/00007632-200112150-00009 ↗
10. Enhancement of pedicle screw stability using calcium phosphate cement in osteoporotic vertebrae: In vivo biomechanical study10.1007/s10776-003-0639-6 ↗
11. Histology and stability study of cortical bone graft influence on titanium implants10.1016/j.tripleo.2006.11.043 ↗
12. Stability assessments and histology of titanium implants placed simultaneously with autogenous onlay bone in the rabbit tibia10.1016/S0901-5027(98)80019-2 ↗
13. The effects of guided bone regeneration and grafting on implants placed into immediate extraction sockets. An experimental study in dogs10.1902/jop.1998.69.8.927 ↗
14. Histomorphometric and removal torque analysis for TiO2-blasted titanium implants. An experimental study on dogs10.1034/j.1600-0501.1992.030205.x ↗
15. Mechanical and histologic evaluation of Ca-P plasma-spray and magnetron sputter-coated implants in trabecular bone of the goat10.1002/(SICI)1097-4636(199707)36:1<75::AID-JBM9>3.0.CO;2-I ↗
16. Quantitative and qualitative investigations of surface enlarged titanium and titanium alloy implants10.1034/j.1600-0501.1998.090101.x ↗
17. Effectiveness of a bone substitute (CERAMENT™) as an alternative to PMMA in percutaneous vertebroplasty: 1-year follow-up on clinical outcome10.1007/s00586-012-2228-9 ↗
18. Biodegradation and biocompatability of a calcium sulphate-hydroxyapatite bone substitute10.1302/0301-620X.86B1.14040 ↗
19. The use of plaster of Paris to fill defects in bone
20. In vivo evaluation of resorbable bone graft substitutes in a rabbit tibial defect model10.1016/j.biomaterials.2004.02.014 ↗
21. Bone substitute as an onlay graft on rat tibia10.1111/j.1600-0501.2009.01875.x ↗
22. Biological factors involved in the osseointegration of oral titanium implants with different surfaces: A pilot study in minipigs10.1902/jop.2005.76.10.1710 ↗
23. Strength of fixation of anterior vertebral body screws10.1097/00007632-199602150-00007 ↗
24. Influence of mono- and bicortical anchorage on the integration of titanium implants. A study in the rabbit tibia10.1016/S0901-5027(96)80036-1 ↗
25. Osteoinduction, osteoconduction and osseointegration10.1007/s005860100282 ↗
26. Zampelis, V., Tagil, M., Lidgren, L., Isaksson, H., Atroshi, I., and Wang, J.S. (2013). The effect of a biphasic injectable bone substitute on the interface strength in a rabbit knee prosthesis model. J. Orthop. Surg. Res., 8.10.1186/1749-799X-8-25 ↗
27. Understanding mechanisms and factors related to implant fixation; a model study of removal torque10.1016/j.jmbbm.2014.02.006 ↗
28. Torque and histomorphometric evaluation of c.p. titanium screws blasted with 25- and 75-microns-sized particles of Al2O310.1002/(SICI)1097-4636(199602)30:2<251::AID-JBM16>3.0.CO;2-P ↗