In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications
Source abstract
Abstract
In situ forming hydrogels are a class of biomaterials that can fulfil a variety of important biomedically relevant functions and hold promise for the emerging field of patient-specific treatments (e.g., cell therapy, drug delivery). Here we report the results of our investigations on the generation of in situ forming hydrogels with potential for wound healing applications (e.g., complex blast injuries). The combination of polysaccharides that were oxidized to display aldehydes, amine displaying chitosan and nanostructured ZnO yields in situ forming bionanocomposite hydrogels. The physicochemical properties of the components, their cytotoxicity towards HaCat cells and the in vitro release of zinc ions on synthetic skin were studied. The in situ gel formation process was complete within minutes, the components were non-toxic towards HaCat cells at functional levels, Zn2+ was released from the gels, and such materials may facilitate wound healing.
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Research context
OpenAlex topics: Hydrogels: synthesis, properties, applications · Electrospun Nanofibers in Biomedical Applications · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry, Lancaster University, Lancaster LA1 4YB, UK
Department of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YG, UK
Politecnico di Torino, Department of Applied Science and Technology, Corso Duca Degli Abruzzi 24, 10129 Turin, Italy
Lancashire Teaching Hospitals NHS Trust, Emergency Department, Royal Preston Hospital, Sharoe Green Lane, Preston PR2 9HT, UK
Advanced Medical Solutions Group PLC., Premier Park, 33 Road One, Winsford Industrial Estate, Winsford, Cheshire CW7 3RT, UK
Materials Science Institute, Lancaster University, Lancaster LA1 4YB, UK
Funding
Royal Society of Chemistry · Royal Society · Biotechnology and Biological Sciences Research Council · Medical Research Council
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