Recent Developments in Zn-Based Biodegradable Materials for Biomedical Applications
Source abstract
Abstract
Zn-based biodegradable alloys or composites have the potential to be developed to next-generation orthopedic implants as alternatives to conventional implants to avoid revision surgeries and to reduce biocompatibility issues. This review summarizes the current research status on Zn-based biodegradable materials. The biological function of Zn, design criteria for orthopedic implants, and corrosion behavior of biodegradable materials are briefly discussed. The performance of many novel zinc-based biodegradable materials is evaluated in terms of biodegradation, biocompatibility, and mechanical properties. Zn-based materials perform a significant role in bone metabolism and the growth of new cells and show medium degradation without the release of excessive hydrogen. The addition of alloying elements such as Mg, Zr, Mn, Ca, and Li into pure Zn enhances the mechanical properties of Zn alloys. Grain refinement by the application of post-processing techniques is effective for the development of many suitable Zn-based biodegradable materials.
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Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · Corrosion Behavior and Inhibition · Orthopaedic implants and arthroplasty
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Mechanical Engineering, COMSATS University Islamabad, Sahiwal Campus, Punjab 57000, Pakistan
Department of Chemistry, College of Science, King Khalid University, Abha 61413, Saudi Arabia
Department of Mechanical Engineering, Sejong University, Seoul 05006, Republic of Korea
Department of Mechanical Engineering, Gachon University, Seongnam-si 13120, Republic of Korea
References (100+)
Show source-provided references
1. Current Advances in the Roles of Doped Bioactive Metal in Biodegradable Polymer Composite Scaffolds for Bone Repair: A Mini Review10.1002/adem.202101510 ↗
2. Recent Progress in Mg-Based Alloys as a Novel Bioabsorbable Biomaterials for Orthopedic Applications10.1016/j.jma.2022.02.013 ↗
3. Thermal Based Surface Modification Techniques for Enhancing the Corrosion and Wear Resistance of Metallic Implants: A Review10.1016/j.vacuum.2022.111298 ↗
4. Research Progress of Biodegradable Magnesium-Based Biomedical Materials: A Review10.1016/j.jallcom.2022.166377 ↗
5. Abraham, A.M., and Venkatesan, S. (2022). A Review on Application of Biomaterials for Medical and Dental Implants. Proc. Inst. Mech. Eng. Part L J. Mater. Des. Appl., 14644207221121981.
6. Poly-Ether-Ether-Ketone (PEEK) in Orthopaedic Practice- A Current Concept Review10.1016/j.jorep.2022.03.013 ↗
7. Liu, Y., Du, T., Qiao, A., Mu, Y., and Yang, H. (2022). Zinc-Based Biodegradable Materials for Orthopaedic Internal Fixation. J. Funct. Biomater., 13.10.3390/jfb13040164 ↗
8. Paiva, J.C.C., Oliveira, L., Vaz, M.F., and Costa-de-Oliveira, S. (2022). Biodegradable Bone Implants as a New Hope to Reduce Device-Associated Infections—A Systematic Review. Bioengineering, 9.10.3390/bioengineering9080409 ↗
9. Synthetic Biodegradable Polyesters for Implantable Controlled-Release Devices10.1080/17425247.2022.2131768 ↗
10. In Vitro Degradation and In Vivo Biocompatibility of Strontium-Doped Magnesium Phosphate-Reinforced Magnesium Composites10.1021/acsbiomaterials.2c00142 ↗
11. Progress in Manufacturing and Processing of Degradable Fe-Based Implants: A Review10.1007/s40204-022-00189-4 ↗
12. Lin, X., Wu, X., Wu, K., Chen, J., Tan, L., Witte, F., Yang, H., Mantovani, D., and Zhou, H. (2022). Biodegradable Mg-Based Alloys: Biological Implications and Restorative Opportunities. Int. Mater. Rev.10.1080/09506608.2022.2079367 ↗
13. Biodegradable Magnesium Phosphates in Biomedical Applications10.1039/D1TB02836G ↗
14. In Vitro and in Vivo Degradation Assessment and Preventive Measures of Biodegradable Mg Alloys for Biomedical Applications10.1002/jbm.a.37297 ↗
15. Improving the Corrosion Behavior of Magnesium Alloys with a Focus on AZ91 Mg Alloy Intended for Biomedical Application by Microstructure Modification and Coating10.1177/09544119221105705 ↗
16. Development of Degradable Magnesium-Based Metal Implants and Their Function in Promoting Bone Metabolism (A Review)
17. A Review on Recent Advancements in Biodegradable Mg-Ca Alloys10.1016/j.jma.2022.08.002 ↗
18. Di, T., Xu, Y., Liu, D., and Sun, X. (2022). Microstructure, Mechanical Performance and Anti-Bacterial Activity of Degradable Zn-Cu-Ag Alloy. Metals, 12.10.3390/met12091444 ↗
19. A Biodegradable Fe/Zn–3Cu Composite with Requisite Properties for Orthopedic Applications10.1016/j.actbio.2022.04.048 ↗
20. Wątroba, M., Bednarczyk, W., Szewczyk, P.K., Kawałko, J., Mech, K., Grünewald, A., Unalan, I., Taccardi, N., Boelter, G., and Banzhaf, M. (2022). In Vitro Cytocompatibility and Antibacterial Studies on Biodegradable Zn Alloys Supplemented by a Critical Assessment of Direct Contact Cytotoxicity Assay. J. Biomed. Mater. Res. Part B Appl. Biomater.10.1002/jbm.b.35147 ↗
21. A Review on Current Research Status of the Surface Modification of Zn-Based Biodegradable Metals
22. Opportunities and Challenges of Biodegradable Zn-Based Alloys10.1016/j.jmst.2019.12.014 ↗
23. Recent Research and Progress of Biodegradable Zinc Alloys and Composites for Biomedical Applications: Biomechanical and Biocorrosion Perspectives
24. Design Biodegradable Zn Alloys: Second Phases and Their Significant Influences on Alloy Properties
25. Recent Advances on the Mechanical Behavior of Zinc Based Biodegradable Metals Focusing on the Strain Softening Phenomenon10.1016/j.actbio.2022.08.041 ↗
26. Zinc-Nutrient Element Based Alloys for Absorbable Wound Closure Devices Fabrication: Current Status, Challenges, and Future Prospects10.1016/j.biomaterials.2021.121301 ↗
27. Utilizing Biodegradable Alloys as Guided Bone Regeneration (GBR) Membrane: Feasibility and Challenges10.1007/s40843-022-2118-3 ↗
28. Zupo, R., Sila, A., Castellana, F., Bringiotti, R., Curlo, M., De Pergola, G., De Nucci, S., Giannelli, G., Mastronardi, M., and Sardone, R. (2022). Prevalence of Zinc Deficiency in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. Nutrients, 14.10.3390/nu14194052 ↗
29. Zinc and Gut Microbiota in Health and Gastrointestinal Disease under the COVID-19 Suggestion10.1002/biof.1829 ↗
30. Husain, H., and Ahmad, R. (2022). Role of Zinc in Liver Pathology. Microb. Biofertil. Micronutr. Availab., 101–113.10.1007/978-3-030-76609-2_5 ↗
31. Allai, F.M., Gul, K., Zahoor, I., Ganaie, T.A., Nasir, G., and Azad, Z.R. (2022). Malnutrition: Impact of Zinc on Child Development. Microb. Biofertil. Micronutr. Availab., 83–100.10.1007/978-3-030-76609-2_4 ↗
32. Conformational Remodeling Enhances Activity of Lanthipeptide Zinc-Metallopeptidases10.1038/s41589-022-01018-2 ↗
33. A Biomimetic Zeolite-Based Nanoenzyme Contributes to Neuroprotection in the Neurovascular Unit after Ischaemic Stroke via Efficient Removal of Zinc and ROS10.1016/j.actbio.2022.03.018 ↗
34. Catalytic Potential of Endophytes Facilitates Synthesis of Biometallic Zinc Oxide Nanoparticles for Agricultural Application10.1007/s10534-022-00417-1 ↗
35. Regulation of Zinc-Dependent Enzymes by Metal Carrier Proteins10.1007/s10534-022-00373-w ↗
36. Effects of Zinc Glycinate on Growth Performance, Serum Biochemical Indexes, and Intestinal Morphology of Yellow Feather Broilers10.1007/s12011-021-02990-x ↗
37. Herrera-Quintana, L., Vázquez-Lorente, H., Molina-López, J., Gamarra-Morales, Y., Martín-López, J.I., and Planells, E. (2022). Vitamin D Status in Critically Ill Patients with SIRS and Its Relationship with Circulating Zn and Related Parameters during ICU Stay. Nutrients, 14.10.3390/nu14173580 ↗
38. Enhanced Anti-Biofilm and Biocompatibility of Zn and Mg Substituted β-Tricalcium Phosphate/Functionalized Multiwalled Carbon Nanotube Composites towards A. Baumannii and Methicillin-Resistant Staphylococcus Aureus, and MG-63 Cells10.1016/j.ijpharm.2022.122248 ↗
39. Fabrication of Magnesium Phosphate Bone Cement with Enhanced Osteogenic Properties by Employing Zeolitic Imidazolate Framework-810.1557/s43578-022-00663-6 ↗
40. Kazachenko, A.S., Vasilieva, N.Y., Malyar, Y.N., Karacharov, A.A., Kondrasenko, A.A., Levdanskiy, A.V., Borovkova, V.S., Miroshnikova, A.V., Issaoui, N., and Kazachenko, A.S. (2022). Sulfation of Arabinogalactan with Ammonium Sulfamate. Biomass Convers. Biorefin.10.1007/s13399-021-02250-x ↗
41. The Influence of Alloying and Fabrication Techniques on the Mechanical Properties, Biodegradability and Biocompatibility of Zinc: A Comprehensive Review10.1016/j.actbio.2019.01.035 ↗
42. Sustainable Biomaterials and Their Applications: A Short Review10.1016/j.matpr.2020.01.437 ↗
43. Drug-Loaded Biomaterials for Orthopedic Applications: A Review10.1016/j.jconrel.2022.02.029 ↗
44. A Review of Current Challenges and Prospects of Magnesium and Its Alloy for Bone Implant Applications10.1007/s40204-022-00182-x ↗
45. A Biodegradable in Situ Zn–Mg2Ge Composite for Bone-Implant Applications10.1016/j.actbio.2022.05.017 ↗
46. Performance Analysis of Biodegradable Materials for Orthopedic Applications10.1016/j.mtcomm.2022.103167 ↗
47. Corrosion Behavior of Biodegradable Metals in Two Different Simulated Physiological Solutions: Comparison of Mg, Zn and Fe10.1016/j.corsci.2021.109278 ↗
48. Ghali, E. (2010). Corrosion Resistance of Aluminum and Magnesium Alloys: Understanding, Performance, and Testing, John Wiley and Sons.10.1002/9780470531778 ↗
49. Biodegradation Behaviour of Fe-Based Alloys in Hanks’ Balanced Salt Solutions: Part II. The Evolution of Local PH and Dissolved Oxygen Concentration at Metal Interface
50. A PH-Sensitive Self-Healing Coating for Biodegradable Magnesium Implants10.1016/j.actbio.2019.04.045 ↗
51. Localized Currents and PH Distribution Studied during Corrosion of MA8 Mg Alloy in the Cell Culture Medium10.1016/j.corsci.2020.108689 ↗
52. Influences of Albumin on in Vitro Corrosion of Pure Zn in Artificial Plasma10.1016/j.corsci.2019.04.003 ↗
53. Initial Formation of Corrosion Products on Pure Zinc in Saline Solution
54. Control of Degradation Rate of Mg Alloys Using Silica Sol–Gel Coatings for Biodegradable Implant Materials10.1007/s10971-018-4824-6 ↗
55. Effect of Exposure Time on Corrosion Behavior of Zinc-Alloy in Simulated Body Fluid Solution: Electrochemical and Surface Investigation10.1016/j.jmrt.2020.12.050 ↗
56. Biodegradation of Crude Oil in Seawater by Using a Consortium of Symbiotic Bacteria10.1016/j.envres.2022.113721 ↗
57. A Study on the Uptake of Methylene Blue by Biodegradable and Eco-Friendly Carboxylated Starch Grafted Polyvinyl Pyrrolidone10.1016/j.envres.2022.114241 ↗
58. A Biodegradable Zn-1Cu-0.1Ti Alloy with Antibacterial Properties for Orthopedic Applications10.1016/j.actbio.2020.02.017 ↗
59. Binary Zn–Ti Alloys for Orthopedic Applications: Corrosion and Degradation Behaviors, Friction and Wear Performance, and Cytotoxicity10.1016/j.jmst.2020.10.031 ↗
60. Laser Additive Manufacturing of Zn Metal Parts for Biodegradable Applications: Processing, Formation Quality and Mechanical Properties10.1016/j.matdes.2018.05.057 ↗
61. Synthesis and Characterization of Mg-Zn-Mn-HA Composite by Spark Plasma Sintering Process for Orthopedic Applications10.1016/j.vacuum.2018.06.063 ↗
62. Development of Biodegradable Zn–1Mg–0.1RE (RE = Er, Dy, and Ho) Alloys for Biomedical Applications10.1016/j.actbio.2020.09.036 ↗
63. Biodegradable Zn–3Cu and Zn–3Cu–0.2Ti Alloys with Ultrahigh Ductility and Antibacterial Ability for Orthopedic Applications10.1016/j.jmst.2020.06.052 ↗
64. Microstructure, Mechanical, Corrosion Properties and Cytotoxicity of Beta-calcium Polyphosphate Reinforced ZK61 Magnesium Alloy Composite by Spark Plasma Sintering10.1016/j.msec.2019.02.050 ↗
65. Fabrication and Characterization of In Situ Zn-TiB2 Nanocomposite10.1016/j.promfg.2020.05.055 ↗
66. Manufacturing and Characterization of Zn-WC as Potential Biodegradable Material10.1016/j.promfg.2019.06.146 ↗
67. Novel Zinc/Tungsten Carbide Nanocomposite as Bioabsorbable Implant10.1016/j.matlet.2019.127282 ↗
68. Galib, R., and Sharif, A. (2015). Development of Zn-Mg Alloys as a Degradable Biomaterial.
69. Effects of Alloying Elements (Ca and Sr) on Microstructure, Mechanical Property and in Vitro Corrosion Behavior of Biodegradable Zn–1.5Mg Alloy10.1016/j.jallcom.2015.10.116 ↗
70. Fabrication of Biodegradable Zn-Al-Mg Alloy: Mechanical Properties, Corrosion Behavior, Cytotoxicity and Antibacterial Activities10.1016/j.msec.2016.11.138 ↗
71. Near-Eutectic Zn-Mg Alloys: Interrelations of Solidification Thermal Parameters, Microstructure Length Scale and Tensile/Corrosion Properties10.1016/j.cap.2019.02.013 ↗
72. Characterization of Nanostructured Biodegradable Zn-Mn Alloy Synthesized by Mechanical Alloying10.1016/j.jallcom.2017.11.155 ↗
73. Selective Laser Melting of Zn–Ag Alloys for Bone Repair: Microstructure, Mechanical Properties and Degradation Behaviour10.1080/17452759.2018.1458991 ↗
74. Effects of the Intermetallic Phases on Microstructure and Properties of Biodegradable Magnesium Matrix and Zinc Matrix Prepared by Powder Metallurgy10.2320/matertrans.M2018142 ↗
75. Extrusion of the Biodegradable ZnMg0.8Ca0.2 Alloy—The Influence of Extrusion Parameters on Microstructure and Mechanical Characteristics10.1016/j.jmbbm.2020.103796 ↗
76. Ultrafine- and Uniform-Grained Biodegradable Zn-0.5Mn Alloy: Grain Refinement Mechanism, Corrosion Behavior, and Biocompatibility in Vivo10.1016/j.msec.2020.111391 ↗
77. The Effects of Alloying with Cu and Mn and Thermal Treatments on the Mechanical Instability of Zn-0.05Mg Alloy10.1016/j.msea.2019.138529 ↗
78. Microstructure and Mechanical Properties of the Micrograined Hypoeutectic Zn–Mg Alloy10.1007/s12613-016-1336-7 ↗
79. Thermal Parameters and Microstructural Development in Directionally Solidified Zn-Rich Zn-Mg Alloys10.1007/s11661-016-3494-7 ↗
80. Structural and Mechanical Aspects of Hypoeutectic Zn–Mg Binary Alloys for Biodegradable Vascular Stent Applications
81. Highly Ductile Zn-2Fe-WC Nanocomposite as Biodegradable Material10.1007/s11661-020-05878-y ↗
82. A High-Strength and Biodegradable Zn–Mg Alloy with Refined Ternary Eutectic Structure Processed by ECAP10.1007/s40195-020-01027-x ↗
83. Biocompatibility and Biodegradation Studies of a Commercial Zinc Alloy for Temporary Mini-Implant Applications10.1038/s41598-017-15873-w ↗
84. Novel High-Strength, Low-Alloys Zn-Mg (< 0.1 Wt% Mg) and Their Arterial Biodegradation10.1016/j.msec.2017.11.021 ↗
85. Alloying Design of Biodegradable Zinc as Promising Bone Implants for Load-Bearing Applications
86. Structure, Mechanical Characteristics and in Vitro Degradation, Cytotoxicity, Genotoxicity and Mutagenicity of Novel Biodegradable Zn–Mg Alloys10.1016/j.msec.2015.08.015 ↗
87. Novel Zn-Based Alloys for Biodegradable Stent Applications: Design, Development and in Vitro Degradation10.1016/j.jmbbm.2016.03.018 ↗
88. Mechanical Strength, Biodegradation, and in Vitro and in Vivo Biocompatibility of Zn Biomaterials10.1021/acsami.8b20634 ↗
89. A Combined Strategy to Enhance the Properties of Zn by Laser Rapid Solidification and Laser Alloying10.1016/j.jmbbm.2018.03.018 ↗
90. A New Approach to Plastic Deformation of Biodegradable Zinc Alloy with Magnesium and Its Effect on Microstructure and Mechanical Properties10.1016/j.matlet.2017.09.090 ↗
91. Indirectly Extruded Biodegradable Zn-0.05wt%Mg Alloy with Improved Strength and Ductility: In Vitro and in Vivo Studies10.1016/j.jmst.2018.01.006 ↗
92. Effect of Cumulative Strain on the Microstructural and Mechanical Properties of Zn-0.02 Wt%Mg Alloy Wires during Room-Temperature Drawing Process10.1016/j.jallcom.2018.01.059 ↗
93. Processing of Zn-3Mg Alloy by Equal Channel Angular Pressing for Biodegradable Metal Implants10.1016/j.jksus.2017.07.008 ↗
94. Mechanical Properties, in Vitro Degradation Behavior, Hemocompatibility and Cytotoxicity Evaluation of Zn–1.2Mg Alloy for Biodegradable Implants10.1039/C6RA14300H ↗
95. In Vitro and in Vivo Studies of Zn-Mn Biodegradable Metals Designed for Orthopedic Applications10.1016/j.actbio.2020.03.009 ↗
96. Enhancement in Mechanical and Corrosion Resistance Properties of a Biodegradable Zn-Fe Alloy through Second Phase Refinement10.1016/j.msec.2020.111197 ↗
97. Kafri, A., Ovadia, S., Goldman, J., Drelich, J., and Aghion, E. (2018). The Suitability of Zn–1.3%Fe Alloy as a Biodegradable Implant Material. Metals, 8.10.3390/met8030153 ↗
98. Potential Biodegradable Zn-Cu Binary Alloys Developed for Cardiovascular Implant Applications10.1016/j.jmbbm.2017.05.013 ↗
99. Investigation of Zinc-copper Alloys as Potential Materials for Craniomaxillofacial Osteosynthesis Implants10.1016/j.msec.2019.109826 ↗
100. Zn-Li Alloy after Extrusion and Drawing: Structural, Mechanical Characterization, and Biodegradation in Abdominal Aorta of Rat10.1016/j.msec.2017.02.167 ↗