Synthesis and Characterization of Modified Chitosan Materials with Assessment of Their Antibacterial and Antiviral Activities
Source abstract
Abstract
Modified chitosan (Cs) derivatives were synthesized and evaluated as potential antibacterial and antiviral coatings of medical protective equipment (facial masks, gloves, …). Quaternized chitosan (HTCC) and chitosan–silver nanocomposites (Ag/Cs) were successfully prepared, with structural characterization confirming efficient quaternization and uniform incorporation of silver nanoparticles. Antibacterial testing revealed that HTCC exhibited concentration-dependent activity, while Ag/Cs showed strong broad-spectrum antibacterial effects and enhanced thermal stability. Antiviral assays against SARS-CoV-2 demonstrated significant viral inhibition for HTCC6 and Ag/Cs at non-cytotoxic concentrations (6 mg/mL), highlighting the role of cationic charge and nanoparticle inclusion in antiviral efficacy. These findings indicate that the developed chitosan derivatives are promising candidates for sustainable functional coatings on medical devices, offering potential applications in infection prevention.
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Research context
OpenAlex topics: Nanocomposite Films for Food Packaging · Antimicrobial agents and applications · Nanoparticles: synthesis and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Textile Materials and Processes Laboratory (MPTex), National Engineering School of Monastir (ENIM), University of Monastir, Monastir 5019, Tunisia
Textile Science and TechnologyResearch Center in Monastir (CRSTTM), University of Monastir, Monastir 5019, Tunisia
LPIM (EA 4567), ENSCMu, University of Haute Alsace (UHA), 68093 Mulhouse, France
LPMT (UR 4365), ENSISA, University of Haute-Alsace (UHA), 68093 Mulhouse, France
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