Autologous Tooth-Derived Biomaterials in Alveolar Bone Regeneration: A Systematic Review of Clinical Outcomes and Histological Evidence
Source abstract
Abstract
Background: Autologous tooth-derived grafts have recently gained attention as an innovative alternative to conventional biomaterials for alveolar ridge preservation (ARP) and augmentation (ARA). Their structural similarity to bone and osteoinductive potential support clinical use. Methods: This systematic review was conducted according to PRISMA 2020 guidelines and registered in PROSPERO (CRD420251108128). A comprehensive search was performed in PubMed, Scopus, and Web of Science (2010–2025). Randomized controlled trials (RCTs), split-mouth, and prospective clinical studies evaluating autologous dentin-derived grafts were included. Two reviewers independently extracted data and assessed risk of bias using Cochrane RoB 2.0 (for RCTs) and ROBINS-I (for non-randomized studies). Results: Nine studies involving 321 patients were included. Autologous dentin grafts effectively preserved ridge dimensions, with horizontal and vertical bone loss significantly reduced compared to controls. Histomorphometric analyses reported 42–56% new bone formation within 4–6 months, with minimal residual graft particles and favorable vascularization. Implant survival ranged from 96–100%, with stable marginal bone levels and no major complications. Conclusions: Autologous tooth-derived biomaterials represent a safe, biologically active, and cost-effective option for alveolar bone regeneration, showing comparable or superior results to xenografts and autologous bone. Further standardized, long-term RCTs are warranted to confirm their role in clinical practice.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Dental Implant Techniques and Outcomes · Periodontal Regeneration and Treatments · Bone Tissue Engineering Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70121 Bari, Italy
Department of Biomedical, Surgical and Dental Sciences, Milano University, 20122 Milan, Italy
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Unit of Maxillo-FacialSurgery and Dentistry, 20122 Milan, Italy
Department of Experimental Medicine, University of Salento, 73100 Lecce, Italy
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