Synthesis and Evaluation of a Molecularly Imprinted Polymer for Selective Solid-Phase Extraction of Irinotecan from Human Serum Samples
Source abstract
Abstract
A molecularly imprinted polymer (MIP) was synthesized by non-covalent imprinting polymerization using irinotecan as template. Methacrylic acid and 4-vinylpyridine were selected as functional monomers. An optimized procedure coupled to LC-PDA analysis was developed for the selective solid-phase extraction of irinotecan from various organic media. A specific capacity of 0.65 µmol•g−1 for the MIP was determined. The high specificity of this MIP was demonstrated by studying the retention behaviour of two related compounds, camptothecin and SN-38. This support was applied for the extraction of irinotecan from human serum samples.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Cancer therapeutics and mechanisms · Antibiotics Pharmacokinetics and Efficacy · Neutropenia and Cancer Infections
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institut des Biomolécules Max Mousseron, Université Montpellier 2, UMR 5247 CNRS-UM1-UM2, case courrier 1705, Place Eugène Bataillon, Montpellier Cedex 05 F-34095, France
Laboratoire de Ciblage Thérapeutique en Cancérologie, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre Bénite F-69495, France
Laboratoire de Cytologie Analytique, Inserm U590, Université Lyon 1, Lyon F-69008, France
References (21)
Show source-provided references
1. Irinotecan (CPT-11): Recent developments and future directions-colorectal cancer and beyond10.1634/theoncologist.6-1-66 ↗
2. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11
3. Case study: Irinotecan (CPT-11), a water-soluble prodrug of SN-38
4. Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by human liver carboxylesterase10.1016/0006-2952(96)00457-1 ↗
5. Proficient metabolism of irinotecan by a human intestinal carboxylesterase
6. Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)
7. Metabolic fate of irinotecan in humans: Correlation of glucuronidation with diarrhea
8. Genetic predisposition to the metabolism of irinotecan (CPT-11)
9. A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues10.1002/jps.2600810718 ↗
10. Simple non-ion-paired high-performance liquid chromatographic method for simultaneous quantitation of carboxylate and lactone forms of 14 new camptothecin derivatives10.1016/S1570-0232(03)00485-9 ↗
11. The current status of camptothecin analogues as antitumor agents10.1093/jnci/85.4.271 ↗
12. Irinotecan and its active metabolite, SN-38: Review of bioanalytical methods and recent update from clinical pharmacology perspective10.1002/bmc.1345 ↗
13. Kinetics of the in vivo interconversion of the carboxylate and lactone forms of irinotecan (CPT-11) and of its metabolite SN-38 in patients
14. Simultaneous determination of the camptothecin analogue CPT-11 and its active metabolite SN-38 by high-performance liquid chromatography: application to plasma pharmacokinetic studies in cancer patients10.1016/0378-4347(92)80156-K ↗
15. High-performance liquid chromatographic technique for the simultaneous determination of lactone and hydroxy acid forms of camptothecin and SN-38 in tissue culture media and cancer cells10.1006/abio.2001.5317 ↗
16. A liquid chromatography/electrospray ionization mass spectrometry (LC-MS/MS) assay for the determination of irinotecan (CPT-11) and its two major metabolites in human liver microsomal incubations and human plasma samples10.1016/j.jchromb.2008.10.011 ↗
17. Molecular imprinting for drug bioanalysis: A review on the application of imprinted polymers to solid-phase extraction and binding assay10.1016/S0378-4347(99)00432-6 ↗
18. Molecularly imprinted sorbent assays: Recent developments and applications10.1002/chem.200802401 ↗
19. Selective sample treatment using molecularly imprinted polymers10.1016/j.chroma.2007.02.109 ↗
20. Molecularly imprinted polymer for analysis of zidovudine and stavudine in human serum by liquid chromatography-mass spectrometry10.1016/j.jchromb.2009.02.068 ↗
21. Development and validation of reversed phase liquid chromatographic method utilizing ultraviolet detection for quantification of irinotecan (CPT-11) and its active metabolite, SN-38, in rat plasma and bile samples: Application to pharmacokinetic studies10.1016/j.talanta.2008.04.058 ↗