journal article·2025-12-16Open access

Three-Dimensional Printing of Calcium Phosphate-Mesoporous Bioactive Glass Scaffolds for Bone Tissue Engineering

Ana Beatriz Gomes de Carvalho, Lais Medeiros Cardoso, Igor Paulino Mendes Soares, Joyce Rodrigues de Souza, Arpita Roy, Prabaha Sikder, Aldo R. Boccaccini, Eliandra de Sousa Trichês, Marco C. Bottino

Journal of Functional Biomaterials· Volume 16· Issue 12

Abstract

Calcium phosphate cements (CPCs) and biomaterials, such as mesoporous bioactive glass (MBG), are critical for bone tissue engineering. This study aimed to 3D-print CPC scaffolds modified with MBG to enhance their osteogenic potential and regenerative ability. MBG powder was synthesized and characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), and nitrogen adsorption–desorption techniques. A commercial CPC ink (hydroxyapatite/α-tricalcium phosphate) was mixed with 5% MBG (w/w; CPC/MBG), and, after rheological assessment, the mixture was used to obtain scaffolds via 3D printing. These scaffolds were then tested for chemical, morphological, and mechanical properties, as well as ion release analysis. Unmodified CPC 3D-printed scaffolds served as controls. Biological experiments, including cell viability, DNA content, cell adhesion/spreading, and osteogenic gene expression, were performed by seeding alveolar bone-derived mesenchymal stem cells onto the scaffolds. Statistics were performed using Student’s t-test and ANOVA with post hoc tests (α = 5%). MBG characterization showed a typical mesoporous structure with aligned microchannels and an amorphous structure. Both formulations released calcium and phosphate ions; however, CPC/MBG also released silicon. Cell viability, adhesion/spreading, and DNA content were significantly greater in CPC/MBG scaffolds compared to CPC (p < 0.05) after 3 and 7 days of culture. Furthermore, CPC/MBG supported increased expression of key osteogenic genes, including collagen (COL1A1), osteocalcin (OCN), and Runt-related transcription factor 2 (RUNX2), after 14 days (p < 0.05). The combination of CPC ink with MBG particles effectively enhances the biocompatibility and osteogenic potential of the scaffold, making it an innovative bioceramic ink formulation for 3D printing personalized scaffolds for bone regeneration.
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Research context

OpenAlex topics: Bone Tissue Engineering Materials · Dental Implant Techniques and Outcomes · Magnesium Alloys: Properties and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA

Department of Dental Materials and Prosthodontics, São Paulo State University, São José dos Campos 12245-000, SP, Brazil

Department of Dental Materials and Prosthodontics, São Paulo State University, Araraquara 14801-385, SP, Brazil

Department of Mechanical Engineering, Cleveland State University, Cleveland, OH 44115, USA

Institute of Biomaterials, University of Erlangen-Nuremberg, 91085 Erlangen, Germany

Institute of Science and Technology, Federal University of São Paulo, São José dos Campos 12231-280, SP, Brazil

Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI 48109, USA

Funding

National Institutes of Health · São Paulo Research Foundation

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