Developing Bioengineered 3D-Printed Composite Scaffolds with Antimicrobial Potential for Bone Tissue Regeneration
Source abstract
Abstract
This research activity proposes to produce composite hydrogel–bioactive glass. The primary purpose of this research is to develop and optimize 3D-printed scaffolds using doped bioglass, aimed at enhancing bone regeneration in bone defects. The bioglass, a bioactive material known for its bone-bonding ability (SiO2–P2O5–CaO–Na2O), co-doped with europium and silver was synthesized and doped to improve its biological properties. This doped bioglass was then combined with a biocompatible hydrogel, chosen for its adequate cellular response and printability. The composite material was printed to form a scaffold, providing a structure that not only supports the damaged bone but also encourages osteogenesis. A variety of methods were employed to assess the rheological, compositional, and morphological characteristics of the samples: Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) coupled with energy-dispersive X-ray spectroscopy (EDS). Additionally, simulated body fluid (SBF) immersion for bioactivity monitoring and immunocytochemistry for cell viability were used to evaluate the biological response of the scaffolds.
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Research context
OpenAlex topics: 3D Printing in Biomedical Research · Bone Tissue Engineering Materials · Additive Manufacturing and 3D Printing Technologies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
3D Printing Laboratory, Center of Innovation and e-Health, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania
Faculty of Medical Engineering, University Politehnica of Bucharest, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania
REOROM Laboratory, Hydraulics Department, Politehnica University of Bucharest, 313 Splaiul Independenţei, 060042 Bucharest, Romania
Special Components for Gas Turbines Department, Romanian Research and Development Institute for Gas Turbine COMOTI, 220D Iuliu Maniu, 061126 Bucharest, Romania
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