Sheltering proteins from protease-mediated degradation and a de novo strategy for preventing acute liver injury
Source abstract
Abstract
Restoring protein functions or supplying proteins is considered one of the most powerful therapeutic strategies for many diseases, but it is mainly limited by the denaturation of proteins during encapsulation and degradation by proteases during in vivo delivery, and limits its delivery. Herein, by encapsulating a protein (catalase, an enzyme) in a hexahistidine-metal assembly (HmA) via a de novo strategy under mild conditions, we demonstrated that HmA could maintain the bioactivity of the enzyme, protect the enzyme from proteinase degradation, and deliver the encapsulated protein for the prevention of disease in an acute liver injury model.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Ophthalmology and Optometry
Eye Hospital
School of Biomedical Engineering
Wenzhou Medical University
Wenzhou
Department of Anesthesiology
The First Affiliated Hospital of Wenzhou Medical University
P. R. China
Funding
National Natural Science Foundation of China · Wenzhou Institute of Biomaterials and Engineering · Science and Technology Plan Project of Wenzhou, China · Basic Public Welfare Research Program of Zhejiang Province
References (34)
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