BIOMATERIALS SCIENCE

Andualem Belachew Workie, Mannie Belay Taye, Ferry P. W. Melchels, Melaku Dereje Mamo

The temporal regulation of local microenvironments is a critical challenge in bone tissue engineering. Conventional silicate-based bioceramics frequently exhibit rapid hydrolytic degradation, leading to localized alkaline shifts that compromise osteoblast viability. In this study, we propose a predictive approach for regulating dissolution through thermal phase partitioning in …

Delin Ma, Qichao Zhao, Chaoyang Jin, Yunhao Zhang et al.

Biodegradable magnesium (Mg) alloys are promising orthopedic implants. However, the synergistic effects of their degradation and physiological loading on fracture healing require further investigation. This study evaluated Mg-Zn-Y-Nd alloy intramedullary (IM) nails in a rat tibiofibular fracture model under 10 N axial loading. A combined approach of finite element analysis (FEA…

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Abstract not available. Bibliographic information is searchable.

Haoran Zhou, Shuaijie Liu, Yehong Huo, Junli Yang et al.

Peptides have been shown to self-assemble into non-centrosymmetric structures exhibiting piezoelectricity. However, the piezoelectricity of peptide self-assemblies remains underexplored. Herein, for the first time, we have explored the piezoelectricity of a natural glutathione (GSH) peptide-based crystalline material for power harvesting and biosensing. The crystal structure in…

Autumn C. Hengen, Helena H. Kolon, Marian A. Ackun-Farmmer

Immunosuppressive cancers are characterized by tumor microenvironments (TME) that actively inhibit anti-tumor immune responses. Regulatory T cells (Tregs) within the TME are major players in this disruption, owing to their enhanced suppressive capabilities. Thus, targeting this population may be the key to the success of cancer immunotherapies that fail in certain patients. Not…

Kanghoon Choi, Minju Kim, Monika Lakk, Fiona S. McDonnell et al.

Glaucoma is characterized by progressive stiffening of the trabecular meshwork (TM), which is associated with elevated intraocular pressure and tissue dysfunction. Although substrate stiffness and mechanical stretch both regulate TM homeostasis, their combined effects remain poorly understood. Here, a hydrogel-integrated microfluidic platform is presented that enables simultane…

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Abstract not available. Bibliographic information is searchable.

Authors not provided

Abstract not available. Bibliographic information is searchable.

Xiaohong Li, Kang Yang, Zebin Yang, Muhammad Wajid Ullah et al.

Immunotherapy has emerged as a new clinical paradigm for cancer management, leveraging immunomodulation to enhance systemic antitumor responses. Despite its significant potency and distinct advantages, challenges such as limited patient response rates and immune-related toxicities persist. Although nanomaterial-based delivery systems have been explored to improve local drug ret…

Guikang Wang, Xianying Chen, Shiwen Zheng, Yanjiu Li et al.

Pelvic organ prolapse (POP) reconstruction is increasingly performed by utilizing knitted silk meshes (KSM), yet tracking in vivo degradation kinetics remains challenging due to complex host tissue integration. This study developed an AI-driven semi-empirical framework utilizing Gaussian Process Regression (GPR) to bridge the kinetic mismatch between in vitro and in vivo enviro…

Dawid Rossino, Cheherazade Trouki, Niccoletta Barbani, Massimiliano Labardi et al.

Myocardial infarction remains a global health challenge, necessitating advanced therapeutic strategies to address both acute injury and chronic ventricular remodeling. This study presents an innovative tri-layered bioartificial patch engineered to modulate degradation kinetics and drug release for prolonged cardiac regeneration. By integrating a slower-degrading polycaprolacton…

Buse Sezer, Günnur Pulat

Excessive fibrosis and implant-associated infections remain major challenges in wound healing and post-surgical tissue repair, often resulting in impaired regeneration and long-term complications. Although gelatin methacryloyl (GelMA) hydrogels are widely used in regenerative medicine due to their biocompatibility and tunable physicochemical properties, they intrinsically lack …

Zhe Zong, Guowenlie Gao, Pengqi Wan, Chunsheng Xiao et al.

The spread of antibiotic resistance has become a major challenge in global public health, and there is an urgent need to develop novel antibacterial agents with low resistance. Peptide-based antibacterial agents have attracted increasing attention for their membrane-targeting mechanisms, which may reduce the risk of the development of resistance. Herein, a series of quaternary …

Ya-Jing Ma, Zheng Zhang, Jian-Kang Kang, Xiu-Hai Che et al.

T-cell engagers redirect cytotoxic lymphocytes toward malignant cells, but their efficacy in solid tumors is limited by uneven antigen expression and inefficient effector-target contact. Here, we report a modular dual-tumor-recognition trispecific T-cell nano-engager (Tri-NanoTCE) generated by Fc-mediated assembly of anti-PD-L1, anti-EGFR, and anti-CD3 IgG1 antibodies on an Fcγ…

Xiang Zhou, Xinyao Wang, Haozhan Wang, Cong Zhang et al.

Bacterial infection and excessive reactive oxygen species (ROS) accumulation synergistically disrupt the wound microenvironment and severely impair the healing process. Therefore, multifunctional biomaterials with intrinsic antibacterial and antioxidant properties are highly desirable for the effective treatment of infected wounds. Here, we rationally designed and synthesized t…

Haishuang Zhu, Ruoxi Wang, Min Zhou

The immune system plays a central role in maintaining physiological homeostasis and protecting against infections, cancer, and inflammatory diseases. Immunoengineering, broadly defined as the strategic design and manipulation of immune responses, has emerged as an interdisciplinary field integrating immunology, materials science, and biomedical engineering, enabling substantial…

Antonio Martino, Joshua Moskow, Jason Shenoi, Gabrielle Rogie et al.

Orthopedic diseases impose heterogeneous therapeutic demands, ranging from symptomatic control of inflammation and pain to intra-articular drug delivery, cartilage repair, bone regeneration, and prevention of implant-associated infection. Although hydrogels are widely investigated as tunable biomaterials for these applications, their translational potential is often discussed p…

Mariana Rodrigues, Benedetta Isella, Bernhard Hruschka, Christian Uhl et al.

Sutureless microvascular anastomosis requires dedicated mechanical connectors that reduce surgery time and tissue trauma. Clinically established mechanical couplers are widely used for venous anastomosis, but rely on vessel eversion, which limits their translation to arterial applications. Bioabsorbable endoluminal flared tubular structures may enable a faster and less traumati…

Niels Geysmans, Lotte Vastmans, Ruben Verstraete, Xaveer Van Ostade et al.

Elastin-Like Proteins (ELP) are highly versatile biomaterials with significant potential in tissue-engineering, due to their design flexibility, mechanical properties and tunable stimuli responsiveness. However, expression conditions reported in literature do not always translate to new ELP fusion proteins. This study establishes a methodology to optimize expression conditions …

Volodymyr Deineka, Yevheniia Husak, Marks Truhins, Anastasia Konieva et al.

The biodistribution profile is a critical determinant of the success of nanomaterial applications, governing both therapeutic efficacy and systemic safety in emerging photothermal therapy (PTT) agents. Despite the promise of PTT, the clinical translation of many nanomaterial-based photothermal agents is impeded by intrinsic toxicity and insufficient tumor specificity. Moreover,…