Phospholipid-mimic oxaliplatin prodrug liposome for treatment of the metastatic triple negative breast cancer
Source abstract
Abstract
A phospholipid-mimic oxaliplatin prodrug (Oxalipid) was synthesized, which could self-assemble into a liposomal nanostructure with a drug loading ratio as high as 27 wt%. Compared to free oxaliplatin, the resulting Oxalipid liposome displayed elongated blood circulation, increased tumor accumulation and improved anticancer efficacy against the metastatic triple negative breast cancer (TNBC).
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Drug Research & Center of Pharmaceutics
Shanghai Institute of Materia Medica
Chinese Academy of Sciences
Shanghai 201203
China
University of Chinese Academy of Sciences
Beijing 100049
Drug Discovery and Design Center
State Key Laboratory of Drug Research
National Center for Nanoscience and Technology
Beijing 100190
Funding
National Natural Science Foundation of China
References (28)
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