Dual-functional aggregation-induced emission active chitosan-based hydrogel for the detection and killing of pathogenic bacteria
Source abstract
Abstract
(Gram-negative) bacterial strains without requiring additional antibiotics. This activity is attributed to its membrane-targeting mechanism, which is further confirmed through SEM analysis. The inherent AIE effect facilitates real-time bacterial detection, with preferential accumulation on microbial membranes leading to cell membrane disruption and intracellular penetration. This study introduces a versatile, antibiotic-free strategy for fighting against pathogenic bacterial strains, and it also provides a scalable framework for developing next-generation biomaterials with significant potential in both bacterial detection and therapeutic applications.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Antimicrobial agents and applications · Biosensors and Analytical Detection · Nanoplatforms for cancer theranostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemical and Biological Sciences, National Institute of Technology Meghalaya, Saitsohpen, Sohra (Cherrapunjee)-793108, India
Materials Research Centre, Indian Institute of Science, Bangalore, Karnataka-560012, India
AMR-Research Laboratory, Department of Biological Sciences, Adamas University, Kolkata-700126, India
Department of Chemistry, North-Eastern Hill University, Shillong-793022, India
Funding
Department of Biotechnology, Ministry of Science and Technology, India
References (68)
Show source-provided references
1. Qin · ACS Biomater. Sci. Eng. · 2020 · 6 · 352910.1021/acsbiomaterials.0c00416 ↗
2. Gao · Front. Physiol. · 2012 · 3 · 110.3389/fphys.2012.00321 ↗
3. Martínez-Martínez · Biomacromolecules · 2018 · 19 · 129410.1021/acs.biomac.8b00108 ↗
4. Gan · Adv. Funct. Mater. · 2019 · 29 · 1
5. Dai · ACS Appl. Mater. Interfaces · 2018 · 10 · 1516310.1021/acsami.8b02527 ↗
6. Yang · ACS Appl. Mater. Interfaces · 2016 · 8 · 3217010.1021/acsami.6b10398 ↗
7. Gupta · J. Am. Chem. Soc. · 2018 · 140 · 1213710.1021/jacs.8b06961 ↗
8. Konai · Chem. Commun. · 2020 · 56 · 214710.1039/C9CC06967D ↗
9. Li · Colloids Surf., B · 2019 · 177 · 37010.1016/j.colsurfb.2019.02.029 ↗
10. Landecker · Palgrave Commun. · 2019 · 5 · 110.1057/s41599-019-0251-8 ↗
11. Xin · Adv. Mater. · 2019 · 31 · 1
12. Shuai · Chem. Eng. J. · 2019 · 374 · 30410.1016/j.cej.2019.03.273 ↗
13. Nonejuie · J. Antibiot. · 2016 · 69 · 35310.1038/ja.2015.116 ↗
14. Hu · J. Controlled Release · 2017 · 247 · 14510.1016/j.jconrel.2017.01.003 ↗
15. Wang · Chem. Eng. J. · 2017 · 323 · 5610.1016/j.cej.2017.04.089 ↗
16. Li · Adv. Sci. · 2018 · 5 · 1
17. Asharani · ACS Nano · 2009 · 3 · 27910.1021/nn800596w ↗
18. Brown · Nature · 2016 · 529 · 33610.1038/nature17042 ↗
19. Salick · Adv. Mater. · 2009 · 21 · 412010.1002/adma.200900189 ↗
20. Annabi · Biomaterials · 2017 · 139 · 22910.1016/j.biomaterials.2017.05.011 ↗
21. Maity · Carbohydr. Polym. · 2018 · 193 · 11910.1016/j.carbpol.2018.03.073 ↗
22. Ghorai · ACS Appl. Bio Mater. · 2024 · 7 · 564010.1021/acsabm.4c00696 ↗
23. Jana · ACS Appl. Polym. Mater. · 2022 · 4 · 420810.1021/acsapm.2c00208 ↗
24. Jana · Mater. Today Chem. · 2023 · 33 · 10168410.1016/j.mtchem.2023.101684 ↗
25. Banerjee · Mater. Today Commun. · 2025 · 45 · 11227810.1016/j.mtcomm.2025.112278 ↗
26. Li · Chem. Commun. · 2017 · 53 · 331510.1039/C6CC09408B ↗
27. Qi · Angew. Chem., Int. Ed. · 2019 · 58 · 1622910.1002/anie.201906099 ↗
28. Chen · ACS Appl. Mater. Interfaces · 2018 · 10 · 1143610.1021/acsami.7b18221 ↗
29. Shi · J. Am. Chem. Soc. · 2019 · 141 · 1269710.1021/jacs.9b05329 ↗
30. Lu · Biomacromolecules · 2024 · 25 · 46610.1021/acs.biomac.3c01082 ↗
31. Ramakrishnan · Acc. Chem. Res. · 2019 · 52 · 307510.1021/acs.accounts.9b00320 ↗
32. Guo · Carbohydr Res. · 2007 · 342 · 132910.1016/j.carres.2007.04.006 ↗
33. O'Donnell · Acc. Chem. Res. · 2004 · 37 · 50610.1021/ar0300625 ↗
34. Tamer · Process Biochem. · 2016 · 51 · 172110.1016/j.procbio.2016.08.002 ↗
35. Elshaarawy · RSC Adv. · 2016 · 6 · 2090110.1039/C5RA27489C ↗
36. Casettari · Prog. Polym. Sci. · 2012 · 37 · 65910.1016/j.progpolymsci.2011.10.001 ↗
37. Chen · Pharmaceutics · 2023 · 15 · 109010.3390/pharmaceutics15041090 ↗
38. Batool · Int. J. Biol. Macromol. · 2021 · 185 · 16510.1016/j.ijbiomac.2021.06.023 ↗
39. Kesari · Int. J. Biol. Macromol. · 2023 · 225 · 132310.1016/j.ijbiomac.2022.11.192 ↗
40. Jampafuang · Polymers · 2019 · 11 · 201010.3390/polym11122010 ↗
41. Raju · Materialia · 2021 · 16 · 10108210.1016/j.mtla.2021.101082 ↗
42. Mondal · J. Mater. Chem. B · 2024 · 12 · 1093410.1039/D4TB01318B ↗
43. Sonker · J. Polym. Environ. · 2018 · 26 · 178210.1007/s10924-017-1077-3 ↗
44. K.Król-Morkisz and K.Pielichowska , Thermal Decomposition of Polymer Nanocomposites With Functionalized Nanoparticles , Elsevier Inc. , 2018
45. Corazzari · Polym. Degrad. Stab. · 2015 · 112 · 110.1016/j.polymdegradstab.2014.12.006 ↗
46. Diab · Spectrochim. Acta, Part A · 2011 · 79 · 105710.1016/j.saa.2011.04.019 ↗
47. Chen · Chem. Mater. · 2003 · 79 · 153510.1021/cm021715z ↗
48. Hu · J. Phys. Chem. C · 2009 · 113 · 1584510.1021/jp902962h ↗
49. Nijegorodov · J. Phys. Chem. · 1994 · 98 · 563910.1021/j100073a011 ↗
50. Mei · Adv. Mater. · 2014 · 26 · 542910.1002/adma.201401356 ↗
51. Chakraborty · J. Photochem. Photobiol., A · 2018 · 359 · 5310.1016/j.jphotochem.2018.03.039 ↗
52. Wang · J. Phys. Chem. C · 2013 · 117 · 2681110.1021/jp409557g ↗
53. Ayyavoo · New J. Chem. · 2021 · 45 · 1099710.1039/D1NJ00158B ↗
54. Shellaiah · Biosensors · 2022 · 12 · 55010.3390/bios12070550 ↗
55. Kathiravan · J. Phys. Chem. B · 2014 · 118 · 1357310.1021/jp509697n ↗
56. Kashyap · Nat. Med. · 2011 · 17 · 67610.1038/nm.2357 ↗
57. Diao · Food Control · 2014 · 35 · 10910.1016/j.foodcont.2013.06.056 ↗
58. Mohamed · Int. J. Mol. Sci. · 2012 · 13 · 1119410.3390/ijms130911194 ↗
59. Shyamal · J. Photochem. Photobiol., A · 2017 · 342 · 110.1016/j.jphotochem.2017.03.030 ↗
60. Yuan · Anal. Chem. · 2021 · 93 · 325810.1021/acs.analchem.0c04931 ↗
61. Hande · ChemBioChem · 2020 · 21 · 149210.1002/cbic.201900728 ↗
62. Liu · Spectrochim. Acta, Part A · 2021 · 264 · 12027210.1016/j.saa.2021.120272 ↗
63. Nie · Dyes Pigm. · 2019 · 168 · 4210.1016/j.dyepig.2019.04.034 ↗
64. Yu · Toxicol. Environ. Health Sci. · 2010 · 2 · 15810.1007/BF03216500 ↗
65. Wang · J. Mater. Chem. C · 2021 · 9 · 1282810.1039/D1TC03022A ↗
66. Singh · Mater. Sci. Eng., B · 2023 · 295 · 11658210.1016/j.mseb.2023.116582 ↗
67. Weyesa · Adv. Appl. Bioinf. Chem. · 2021 · 14 · 133
68. Frisch · Gaussian 09, Revision D.01, Gaussian, Inc., Wallingford, CT, 2009 · 2014 · 1