A red emitting carbon dot and aptamer-functionalized alginate system for targeted triple-negative breast cancer imaging
Source abstract
Abstract
The targeted detection of cancer cells is crucial for tumour diagnosis and therapeutic treatment. Recently, luminescent carbon dots have generated wide interest in biomedical applications, thanks to their unique properties such as biocompatibility, tuneable emission, water solubility and the possibility of surface functionalization. Herein, we report the conjugation of red emitting carbon dots (RCDs) to alginate and the sTN58 aptamer to obtain systems able to selectively recognize cancer cells that can be exploited in bioimaging and potentially as photothermal agents.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · Nanoplatforms for cancer theranostics · Carbon and Quantum Dots Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Industrial Chemistry “Toso Montanari”, University of Bologna, Via Piero Gobetti 85, 40129 Bologna, Italy
Institute of Endotypes in Oncology, Metabolism and Immunology “Gaetano Salvatore”, National Research Council, 80131, Naples, Italy
Department for Nanostructured Materials, Jožef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
Jožef Stefan International Postgraduate School, Jamova 39, 1000 Ljubljana, Slovenia
Funding
Università di Bologna · Fondazione AIRC per la ricerca sul cancro ETS · The Slovenian Research and Innovation Agency
References (34)
Show source-provided references
1. https://www.who.int/news-room/fact-sheets/detail/cancer
2. Shen · Theranostics · 2022 · 12 · 286010.7150/thno.70721 ↗
3. Xu · J. Am. Chem. Soc. · 2004 · 126 · 1273610.1021/ja040082h ↗
4. Singh · Adv. Drug Delivery Rev. · 2025 · 224 · 11564410.1016/j.addr.2025.115644 ↗
5. Wang · Small · 2024 · 20 · 230377310.1002/smll.202303773 ↗
6. Bartkowski · Chem. – Eur. J. · 2024 · 30 · e20230398210.1002/chem.202303982 ↗
7. Liu · ACS Cent. Sci. · 2020 · 6 · 217910.1021/acscentsci.0c01306 ↗
8. Alafeef · Small · 2024 · 20 · 230393710.1002/smll.202303937 ↗
9. Bian · Chem. Sci. · 2025 · 16 · 419510.1039/D4SC05843G ↗
10. Liu · Green Chem. · 2019 · 21 · 44910.1039/C8GC02736F ↗
11. Qin · Mater. Chem. Front. · 2024 · 8 · 93010.1039/D3QM00968H ↗
12. Warjurkar · J. Mater. Chem. B · 2023 · 11 · 884810.1039/D3TB01378B ↗
13. Jiang · Carbon · 2024 · 219 · 11883810.1016/j.carbon.2024.118838 ↗
14. Maturi · Nanoscale Adv. · 2025 · 7 · 44810.1039/D4NA00617H ↗
15. Ren · Int. J. Biol. Macromol. · 2024 · 279 · 13501910.1016/j.ijbiomac.2024.135019 ↗
16. Fazal · RSC Adv. · 2023 · 13 · 2308710.1039/D3RA03369D ↗
17. Lee · Prog. Polym. Sci. · 2012 · 37 · 10610.1016/j.progpolymsci.2011.06.003 ↗
18. Pawar · Biomaterials · 2012 · 33 · 327910.1016/j.biomaterials.2012.01.007 ↗
19. Agnello · Explor. Target. Antitumor Ther. · 2021 · 2 · 107
20. Shigdar · Pharmaceutics · 2021 · 14 · 2810.3390/pharmaceutics14010028 ↗
21. Bianchini · Nat. Rev. Clin. Oncol. · 2022 · 19 · 9110.1038/s41571-021-00565-2 ↗
22. Caliendo · Bioact. Mater. · 2025 · 50 · 443
23. Ibarra · Pharmaceutics · 2022 · 14 · 62610.3390/pharmaceutics14030626 ↗
24. Ibarra · Pharmaceutics · 2024 · 16 · 128110.3390/pharmaceutics16101281 ↗
25. Shi · Carbohydr. Polym. · 2025 · 351 · 12311210.1016/j.carbpol.2024.123112 ↗
26. Oudjedi · NanoSelect · 2025 · 6 · e202400107
27. Cai · Signal Transduction Targeted Ther. · 2025 · 10 · 11510.1038/s41392-025-02140-y ↗
28. Zhang · Mater. Chem. Front. · 2023 · 7 · 235910.1039/D3QM00043E ↗
29. Monaco · J. Med. Chem. · 2017 · 60 · 451010.1021/acs.jmedchem.7b00527 ↗
30. Camorani · J. Exp. Clin. Cancer Res. · 2024 · 43 · 9210.1186/s13046-024-03014-x ↗
31. Venegoni · Adv. Healthcare Mater. · 2025 · 14 · e240331410.1002/adhm.202403314 ↗
32. Camorani · iScience · 2020 · 23 · 1009710.1016/j.isci.2020.100979 ↗
33. Camorani · Int. J. Mol. Sci. · 2022 · 23 · 351110.3390/ijms23073511 ↗
34. van Rhoon · Adv. Drug Delivery Rev. · 2020 · 163–164 · 14510.1016/j.addr.2020.03.006 ↗