A multi-effective and long-acting immunotherapy through one single hydrogel based injection
Source abstract
Abstract
A dual-effective (photothermal and immune) therapy employing gold nanorods (AuNRs) with a drug (two macrophage migration inhibitory factor (MIF) inhibitors) sustained release hydrogel was designed in this paper. The subsequent cellular and animal studies demonstrated that the proposed therapy can not only inhibit the proliferation, migration, and recurrence of cancer cells, but also improve the immune function (increase the infiltration of CD8+ killer T cells in tumors) without the traditional multiple injections of expensive immune drugs.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Macrophage Migration Inhibitory Factor · Adenosine and Purinergic Signaling · Synthesis and Biological Evaluation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
The National Engineering Research Center for Bioengineering Drugs and the Technologies
Institute of Translational Medicine
Nanchang University
Nanchang
China
College of Chemistry
Funding
National Natural Science Foundation of China · Education Department of Jiangxi Province · National Key Research and Development Program of China
References (36)
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