journal article·2025Open access

Tumor microenvironment modulation innovates combinative cancer therapy via a versatile graphene oxide nanosystem

Chuxin Cai, Qingming Zhang, Junqiu Ye, Sijia Yao, Qian Li, Zhechen Fan, Sulei Ge, Yukun Wang, Dingyi Xu, Jianping Zhou, Hao Cheng, Yang Ding

Biomaterials Science· Volume 13· Issue 12

Abstract

The tumor microenvironment (TME) emerges as a unique challenge to oncotherapy due to its intricate ecosystem containing diverse cell types, extracellular matrix, secreted factors, and neovascularization, which furnish tumor growth, progression, invasion, and metastasis. Graphene oxide (GO)-based materials have garnered increasing attention in cancer therapy owing to their vast specific surface area, flexible lamellar structure, and electronic-photonic properties. Recently, interactions of GO with the TME have been broadly investigated, including trapping biomolecules, catalysis, cancer stem cell targeting, immunoreactions, etc., which inspires combinative therapeutic strategies to overcome TME obstacles. Herein, we summarize TME features, GO modulating various dimensions of the TME, and a TME-triggerable drug delivery system and highlight innovation and merits in combinative cancer therapy based on TME modulation. This review aims to offer researchers deeper insights into the interactions between versatile GO nanomaterials and the TME, facilitating the development of rational and reliable GO-based nanomedicines for advanced oncotherapy.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Graphene and Nanomaterials Applications · Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China

Department of Pharmacy, Jinling Hospital, No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu, People's Republic of China

Funding

Ten Thousand Talent Plans for Young Top-notch Talents of Yunnan Province · China Pharmaceutical University · Excellent Youth Foundation of Jiangsu Scientific Committee · Fundamental Research Funds for the Central Universities · National Natural Science Foundation of China · Natural Science Foundation of Jiangsu Province · China Postdoctoral Science Foundation

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