Covalent drugs based on small molecules and peptides for disease theranostics
Source abstract
Abstract
Biomacromolecules, such as proteins, nucleic acids and polysaccharides, are widely distributed in the human body, and some of them have been recognized as the targets of drugs for disease theranostics. Drugs typically act on targets in two ways: non-covalent bond and covalent bond. Non-covalent bond-based drugs have some disadvantages, such as structural instability and environmental sensitivity. Covalent interactions between drugs and targets have a longer action time, higher affinity and controllability than non-covalent interactions of conventional drugs. With the development of artificial intelligence, covalent drugs have received more attention and have been developed rapidly in pharmaceutical research in recent years. From the perspective of covalent drugs, this review summarizes the design methods and the effects of covalent drugs. Finally, we discuss the application of covalent peptide drugs and expect to provide a new reference for cancer treatment.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Click Chemistry and Applications · Chemical Synthesis and Analysis · Computational Drug Discovery Methods
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, 450052, P.R. China
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100190, P.R. China
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, No. 19(A) Yuquan Road, Shijingshan District, Beijing 100049, P.R. China
Department of Food and Drug, Laiwu Vocational and Technical, College, Jinan, China
Funding
National Key Research and Development Program of China · Chinese Academy of Sciences · Beijing Nova Program · Youth Innovation Promotion Association · National Natural Science Foundation of China
References (91)
Show source-provided references
1. Bonn · Science · 2021 · 371 · 12310.1126/science.abf3543 ↗
2. De Cesco · Eur. J. Med. Chem. · 2017 · 138 · 9610.1016/j.ejmech.2017.06.019 ↗
3. Haag · Nature · 2018 · 559 · 26910.1038/s41586-018-0287-8 ↗
4. Jiang · Cell Chem. Biol. · 2020 · 27 · 155310.1016/j.chembiol.2020.08.014 ↗
5. Park · J. Med. Chem. · 2022 · 65 · 1050610.1021/acs.jmedchem.2c00652 ↗
6. Morris · J. Comput. Chem. · 1998 · 19 · 163910.1002/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B ↗
7. Trott · J. Comput. Chem. · 2010 · 31 · 45510.1002/jcc.21334 ↗
8. Verdonk · Proteins · 2003 · 52 · 60910.1002/prot.10465 ↗
9. Vuong · J. Chem. Inf. Model. · 2015 · 55 · 273110.1021/acs.jcim.5b00386 ↗
10. Ghosh · ChemMedChem · 2019 · 14 · 88910.1002/cmdc.201900107 ↗
11. Bai · Eur. J. Med. Chem. · 2021 · 221 · 11354310.1016/j.ejmech.2021.113543 ↗
12. Zhong · Signal Transduction Targeted Ther. · 2021 · 6 · 20110.1038/s41392-021-00572-w ↗
13. Planas · Nat. Catal. · 2019 · 2 · 83910.1038/s41929-019-0367-7 ↗
14. Paulussen · J. Pept. Sci. · 2023 · 29 · e345710.1002/psc.3457 ↗
15. Cai · Chem. Soc. Rev. · 2016 · 45 · 598510.1039/C6CS00013D ↗
16. Chen · Bioact. Mater. · 2019 · 4 · 120
17. Pan · ACS Nano · 2015 · 9 · 1125810.1021/acsnano.5b04884 ↗
18. Duggleby · Nature · 1995 · 373 · 26410.1038/373264a0 ↗
19. Wecker · Recent Results Cancer Res. · 2018 · 211 · 19910.1007/978-3-319-91442-8_14 ↗
20. Savi · Platelets · 1998 · 9 · 25110.1080/09537109876799 ↗
21. Sachs · Aliment. Pharmacol. Ther. · 2006 · 23 · 210.1111/j.1365-2036.2006.02943.x ↗
22. McTavish · Drugs · 1991 · 42 · 13810.2165/00003495-199142010-00008 ↗
23. Shin · Curr. Gastroenterol. Rep. · 2008 · 10 · 52810.1007/s11894-008-0098-4 ↗
24. Schafer · Rheumatol. Ther. · 2020 · 7 · 10110.1007/s40744-019-00182-7 ↗
25. Wu · J. Hematol. Oncol. · 2016 · 9 · 2110.1186/s13045-016-0250-9 ↗
26. Cortes · Blood · 2020 · 136 · 4710.1182/blood-2020-139677 ↗
27. Hughes · N. Engl. J. Med. · 2019 · 381 · 231510.1056/NEJMoa1902328 ↗
28. Hallin · Cancer Discovery · 2020 · 10 · 5410.1158/2159-8290.CD-19-1167 ↗
29. Canon · Nature · 2019 · 575 · 21710.1038/s41586-019-1694-1 ↗
30. Skoulidis · N. Engl. J. Med. · 2021 · 384 · 237110.1056/NEJMoa2103695 ↗
31. Dhillon · Drugs · 2023 · 83 · 27510.1007/s40265-023-01839-y ↗
32. Schmidt · Angew. Chem., Int. Ed. · 2017 · 56 · 761510.1002/anie.201703270 ↗
33. Liu · Angew. Chem., Int. Ed. · 2018 · 57 · 1349910.1002/anie.201807181 ↗
34. Tachrim · Catalysts · 2017 · 7 · 4010.3390/catal7020040 ↗
35. Shen · Anal. Chem. · 2023 · 95 · 199510.1021/acs.analchem.2c04358 ↗
36. Mikkelsen · Bioconjugate Chem. · 2022 · 33 · 62510.1021/acs.bioconjchem.2c00045 ↗
37. Li · Green Chem. · 2023 · 25 · 430210.1039/D3GC00664F ↗
38. Lv · Chem · 2022 · 8 · 151810.1016/j.chempr.2022.04.019 ↗
39. Xiao · Biochemistry · 1997 · 36 · 183610.1021/bi962476u ↗
40. González-Morena · Front. Pharmacol. · 2021 · 12 · 80774210.3389/fphar.2021.807742 ↗
41. Obora · Top. Curr. Chem. · 2016 · 374 · 1110.1007/s41061-016-0012-8 ↗
42. Bhongale · Catal. Rev. · 2023 · 65 · 45510.1080/01614940.2021.1930490 ↗
43. Song · Green Chem. · 2018 · 20 · 166210.1039/C8GC00078F ↗
44. Chiorcea-Paquim · J. Pharm. Biomed. Anal. · 2023 · 222 · 11503610.1016/j.jpba.2022.115036 ↗
45. Cozzi · Angew. Chem., Int. Ed. · 2009 · 48 · 131310.1002/anie.200805423 ↗
46. Mori · J. Am. Chem. Soc. · 2000 · 122 · 729410.1021/ja0002060 ↗
47. Liu · Chinese Bull. of Life Sciences(in Chinese) · 2020 · 32 · 11
48. Mather · Prog. Polym. Sci. · 2006 · 31 · 48710.1016/j.progpolymsci.2006.03.001 ↗
49. Heggli · Bioconjugate Chem. · 2003 · 14 · 96710.1021/bc0340621 ↗
50. Wong · Mol. Biol. Evol. · 2010 · 28 · 32710.1093/molbev/msq194 ↗
51. Walsh · Angew. Chem., Int. Ed. · 2005 · 44 · 734210.1002/anie.200501023 ↗
52. Góngora-Benítez · Chem. Rev. · 2014 · 114 · 90110.1021/cr400031z ↗
53. Kadokura · Cell · 2009 · 138 · 116410.1016/j.cell.2009.07.030 ↗
54. Rehder · Biochemistry · 2010 · 49 · 774810.1021/bi1008694 ↗
55. Gok · Biomacromolecules · 2017 · 18 · 246310.1021/acs.biomac.7b00619 ↗
56. Jana · J. Phys. Chem. B · 2016 · 120 · 1303110.1021/acs.jpcb.6b09334 ↗
57. Zhang · Mol. Pharmacol. · 2013 · 83 · 84810.1124/mol.112.084392 ↗
58. Pinner · Eur. J. Inorg. Chem. · 1877 · 10 · 1889
59. Gauthier · Bioorg. Med. Chem. Lett. · 2008 · 18 · 92310.1016/j.bmcl.2007.12.047 ↗
60. Zhang · J. Cleaner Prod. · 2021 · 282 · 12452310.1016/j.jclepro.2020.124523 ↗
61. Mohanty · ChemMedChem · 2021 · 16 · 354510.1002/cmdc.202100447 ↗
62. Dos Santos · J. Chem. Inf. Model. · 2022 · 62 · 408310.1021/acs.jcim.2c00466 ↗
63. Resnick · J. Am. Chem. Soc. · 2019 · 141 · 895110.1021/jacs.9b02822 ↗
64. Zhang · Chem. Sci. · 2022 · 13 · 659910.1039/D2SC00555G ↗
65. St Denis · J. Med. Chem. · 2022 · 65 · 1231910.1021/acs.jmedchem.2c01044 ↗
66. Thiyagarajan · Proc. Natl. Acad. Sci. U. S. A. · 2023 · 120 · e221183212010.1073/pnas.2211832120 ↗
67. Pelliccia · Eur. J. Med. Chem. · 2022 · 244 · 11485310.1016/j.ejmech.2022.114853 ↗
68. Stille · Eur. J. Med. Chem. · 2022 · 229 · 11404610.1016/j.ejmech.2021.114046 ↗
69. Li · ACS Med. Chem. Lett. · 2022 · 13 · 157410.1021/acsmedchemlett.2c00127 ↗
70. Gonzalez-Valero · J. Am. Chem. Soc. · 2022 · 144 · 2289010.1021/jacs.2c04039 ↗
71. Patricelli · Cancer Discovery · 2016 · 6 · 31610.1158/2159-8290.CD-15-1105 ↗
72. Krueger · J. Med. Chem. · 2022 · 65 · 1241710.1021/acs.jmedchem.2c01086 ↗
73. Chan · J. Med. Chem. · 2022 · 65 · 1537410.1021/acs.jmedchem.2c01346 ↗
74. Nguyen · Chem. Sci. · 2020 · 11 · 1203610.1039/D0SC04641H ↗
75. Wang · Eur. J. Med. Chem. · 2022 · 244 · 11480310.1016/j.ejmech.2022.114803 ↗
76. Xie · J. Med. Chem. · 2021 · 64 · 128310.1021/acs.jmedchem.0c01511 ↗
77. Zerhouni · Cancer Res. · 2021 · 81 · 380610.1158/0008-5472.CAN-20-2114 ↗
78. Zhou · ACS Chem. Biol. · 2016 · 11 · 88210.1021/acschembio.5b01043 ↗
79. Qiu · Cell Chem. Biol. · 2022 · 29 · 53010.1016/j.chembiol.2021.07.012 ↗
80. Hua · Int. Immunopharmacol. · 2022 · 113 · 10943110.1016/j.intimp.2022.109431 ↗
81. Zhang · J. Med. Chem. · 2023 · 66 · 172510.1021/acs.jmedchem.2c01370 ↗
82. Liu · Drug Delivery Transl. Res. · 2018 · 8 · 64510.1007/s13346-018-0502-z ↗
83. Zhou · Talanta · 2022 · 240 · 12320410.1016/j.talanta.2021.123204 ↗
84. Farjallah · ACS Infect. Dis. · 2021 · 7 · 55210.1021/acsinfecdis.0c00325 ↗
85. Li · Anal. Chem. · 2020 · 92 · 326210.1021/acs.analchem.9b05102 ↗
86. Huang · Cell Res. · 2023 · 33 · 88710.1038/s41422-023-00868-2 ↗
87. Bao · ACS Med. Chem. Lett. · 2020 · 11 · 218210.1021/acsmedchemlett.0c00323 ↗
88. Stebbins · Chem. Biol. · 2013 · 20 · 97310.1016/j.chembiol.2013.06.008 ↗
89. Ieda · Bioorg. Med. Chem. Lett. · 2019 · 29 · 35310.1016/j.bmcl.2018.12.044 ↗
90. Ma · Eur. J. Med. Chem. · 2022 · 240 · 11457010.1016/j.ejmech.2022.114570 ↗
91. Lidumniece · Proc. Natl. Acad. Sci. U. S. A. · 2021 · 118 · e202269611810.1073/pnas.2022696118 ↗