Fc-fusion mimetics
Source abstract
Abstract
The Fc-fusion mimetic RpR 2[combining low line] was prepared by disulfide bridging conjugation using PEG in the place of the Fc. RpR 2[combining low line] displayed higher affinity for VEGF than aflibercept. This is caused primarily by a slower dissociation rate, which can prolong a drug at its site of action. RpRs have considerable potential for development as stable, organ specific therapeutics.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Monoclonal and Polyclonal Antibodies Research · Nanofabrication and Lithography Techniques · Protein purification and stability
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
UCL School of Pharmacy
University College London
London WC1N 1AX
UK
NIHR Biomedical Research Centre
Moorfields Eye Hospital and UCL Institute of Ophthalmology
London
References (33)
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