Ultrasound-responsive glycopolymer micelles for targeted dual drug delivery in cancer therapy

Shanmeng Lin; Liwei Zhu; Zhiying Li; Siyuan Yue; Zhaohan Wang; Youwei Xu; Yichuan Zhang; Quan Gao; Jie Chen; Ting Yin; Lili Niu; Jin Geng

doi:10.1039/d3bm01101a

journal article·2023Open access

Ultrasound-responsive glycopolymer micelles for targeted dual drug delivery in cancer therapy

Shanmeng Lin, Liwei Zhu, Zhiying Li, Siyuan Yue, Zhaohan Wang, Youwei Xu, Yichuan Zhang, Quan Gao, Jie Chen, Ting Yin, Lili Niu, Jin Geng

Biomaterials Science· Volume 11· Issue 18

Publisher page Open full text

Source abstract

Abstract

Controlled drug release of nanoparticles was achieved by irreversibly disrupting polymer micelles through high-intensity focused ultrasound (HIFU) induction. An ultrasound-responsive block copolymer was synthesized, comprising an end-functional Eosin Y fluorophore, 2-tetrahydropyranyl acrylate (THPA), and acrylate mannose (MAN). The block copolymer was then self-assembled to produce micelles. The chemotherapy drug dasatinib (DAS) and the sonodynamic therapy agent methylene blue (MB) were encapsulated by the self-assembly of the block copolymer. This targeted nanoparticle enables sonodynamic therapy through high-intensity focused ultrasound while triggering nanoparticle disassembly for controlled drug release. The ultrasound-mediated, non-invasive strategy provides external spatiotemporal control for targeted tumour treatment.

Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗

Research context

Polymers Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Ultrasound and Hyperthermia Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China

University of Chinese Academy of Sciences, Beijing, 100049, China

Department of General Surgery, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China

Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Shenzhen Fundamental Research Program

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