A chlorin-lipid nanovesicle nucleus drug for amplified therapeutic effects of lung cancer by internal radiotherapy combined with the Cerenkov radiation-induced photodynamic therapy
Source abstract
Abstract
I-BSA@LCN-Apt produced a powerful anti-tumor effect through synergistic radiotherapy and CR-PDT, which almost caused complete tumor growth regression. After treatment, the survival time of the mice was significantly prolonged. During the treatment, no obvious side effects were found by histopathology of important organs, hematology and biochemistry analysis except the decrease of the white blood cell count (WBC). The study provides a major tool for deep-seated tumors to obtain amplified therapeutic effects by synergistic radiotherapy and CR-PDT without the use of any external light source.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Porphyrin and Phthalocyanine Chemistry
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
CAS Key Laboratory for the Biological Effects of Nanomaterials and Nanosafety
Institute of High Energy Physics
Chinese Academy of Sciences
Beijing 100049
China
CAS Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
Department of Chemistry and Chemical Engineering
Beijing University of Technology
Beijing 100124
Funding
National Natural Science Foundation of China · Natural Science Foundation of Beijing Municipality
References (38)
Show source-provided references
1. Agostinis · Ca-Cancer J. Clin. · 2011 · 61 · 25010.3322/caac.20114 ↗
2. Dolmans · Nat. Rev. Cancer · 2003 · 05 · 38010.1038/nrc1071 ↗
3. Davids · Cancer Treat. Rev. · 2011 · 37 · 465
4. Celli · Chem. Rev. · 2010 · 110 · 279510.1021/cr900300p ↗
5. Silva · Chem. – Eur. J. · 2010 · 16 · 927310.1002/chem.201000111 ↗
6. Dogra · Br. J. Dermatol. · 2007 · 157 · 137
7. Robertson · J. Photochem. Photobiol. · 2009 · 96 · 110.1016/j.jphotobiol.2009.04.001 ↗
8. Cai · Photodiagn. Photodyn. Ther. · 2013 · 10 · 67210.1016/j.pdpdt.2013.08.002 ↗
9. Ferreira · Angew. Chem. · 2019 · 58 · 1323210.1002/anie.201900594 ↗
10. Karnkaew · ACS Nano · 2016 · 10 · 391810.1021/acsnano.6b01401 ↗
11. Cline · Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol. · 2019 · 11 · e1541
12. Lakouas · Photodiagn. Photodyn. Ther. · 2017 · 18 · 23610.1016/j.pdpdt.2017.03.002 ↗
13. Shaffer · Nat. Nanotechnol. · 2017 · 12 · 10610.1038/nnano.2016.301 ↗
14. Cherenkov · Science · 1960 · 131 · 13610.1126/science.131.3394.136 ↗
15. Robertson · Phys. Med. Biol. · 2009 · 54 · N35510.1088/0031-9155/54/16/N01 ↗
16. Kotagiri · Nat. Nanotechnol. · 2015 · 10 · 37010.1038/nnano.2015.17 ↗
17. Duan · ACS Appl. Mater. Interfaces · 2018 · 10 · 527810.1021/acsami.7b17902 ↗
18. Ni · J. Am. Chem. Soc. · 2018 · 140 · 1497110.1021/jacs.8b09374 ↗
19. Kamkaew · ACS Appl. Mater. Interfaces · 2016 · 8 · 2663010.1021/acsami.6b10255 ↗
20. Cerchia · Mol. Ther. · 2012 · 20 · 229110.1038/mt.2012.163 ↗
21. Verma · Mol. Cancer Ther. · 2011 · 10 · 176310.1158/1535-7163.MCT-11-0116 ↗
22. Esposito · Mol. Ther. · 2014 · 22 · 115110.1038/mt.2014.5 ↗
23. Wang · Anal. Chem. · 2015 · 87 · 429910.1021/ac504752a ↗
24. Gao · Biomaterials · 2014 · 35 · 100410.1016/j.biomaterials.2013.10.039 ↗
25. Euhus · J. Surg. Oncol. · 1986 · 31 · 22910.1002/jso.2930310402 ↗
26. Higgins · Cancer · 2014 · 120 · 330210.1002/cncr.28878 ↗
27. Hunter · Proc. Soc. Exp. Biol. Med. · 1970 · 133 · 98910.3181/00379727-133-34611 ↗
28. Robles · Nucl. Med. Biol. · 2001 · 28 · 99910.1016/S0969-8051(01)00261-X ↗
29. Lovell · Nat. Mater. · 2011 · 10 · 32410.1038/nmat2986 ↗
30. Lin · J. Fluoresc. · 2013 · 23 · 4110.1007/s10895-012-1114-5 ↗
31. Unterweger · Nucl. Instrum. Methods · 1992 · 312 · 34910.1016/0168-9002(92)90180-C ↗
32. Li · Oncogene · 2009 · 28 · 344210.1038/onc.2009.212 ↗
33. Kristiansen · Physiol. Plant. · 2009 · 136 · 36910.1111/j.1399-3054.2009.01243.x ↗
34. Oparka · Methods · 2016 · 109 · 310.1016/j.ymeth.2016.06.008 ↗
35. Gao · Adv. Healthcare Mater. · 2017 · 6 · 160145310.1002/adhm.201601453 ↗
36. Wu · Oncotarget · 2014 · 5 · 954610.18632/oncotarget.2542 ↗
37. Trachootham · Nat. Rev. Drug Discovery · 2009 · 8 · 57910.1038/nrd2803 ↗
38. Dayal · J. Cancer Res. Ther. · 2014 · 10 · 81110.4103/0973-1482.146073 ↗