journal article·2021

Fluorinated chitosan-mediated intracellular catalase delivery for enhanced photodynamic therapy of oral cancer

Ting Zhu, Leilei Shi, Chuan Ma, Li Xu, Jiapei Yang, Guoyu Zhou, Xinyuan Zhu, Lingyue Shen

Biomaterials Science· Volume 9· Issue 3
Publisher page

Abstract

A pH-responsive fluorinated chitosan-chlorin e6 (FC-Ce6) was employed here for the intracellular delivery of catalase to relieve the hypoxic micro-environment. Upon simple mixing, FC-Ce6 and catalase co-assemble to form stable nanoparticles, which show a greatly improved cross-membrane penetration capacity compared with catalase alone or nonfluorinated CS-Ce6/catalase nanoparticles. Under catalase catalysis, a high concentration of intracellular H2O2 can be transformed into O2. Upon irradiation, due to the continuous formation of cytotoxic singlet oxygen (1O2), our nanoparticles showed superior anti-cancer activity in contrast to free Ce6 and nonfluorinated CS-Ce6/catalase nanoparticles. Our study proposes an effective intracellular catalase delivery system to overcome hypoxia for enhanced PDT against oral cancer.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Oral & Maxillofacial-Head & Neck Oncology

Department of Laser and Aesthetic Medicine

Shanghai Ninth People's Hospital

College of Stomatology

Shanghai Jiao Tong University School of Medicine

School of Chemistry and Chemical Engineering

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs

Shanghai Jiao Tong University

Shanghai 200240

China

Department of Oral and Maxillofacial Surgery

School and Hospital of Stomatology

Cheeloo College of Medicine

Shandong University and Shandong Key Laboratory of Oral Tissue Regeneration and Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration

Jinan

Funding

National Natural Science Foundation of China

References (28)

Show source-provided references
1. Fan · Chem. Soc. Rev. · 2016 · 45 · 648810.1039/C6CS00616G ↗
2. Henderson · Cancer Res. · 1987 · 47 · 3110
3. Piette · Biochem. Pharmacol. · 2003 · 66 · 165110.1016/S0006-2952(03)00539-2 ↗
4. Shi · ACS Nano · 2020 · 14 · 218310.1021/acsnano.9b09032 ↗
5. Zhu · Theranostics · 2019 · 9 · 329310.7150/thno.32867 ↗
6. Shen · Theranostics · 2017 · 7 · 453710.7150/thno.19546 ↗
7. Lan · J. Am. Chem. Soc. · 2018 · 140 · 567010.1021/jacs.8b01072 ↗
8. Lin · Theranostics · 2018 · 8 · 99010.7150/thno.22465 ↗
9. Wang · Biomaterials · 2018 · 181 · 31010.1016/j.biomaterials.2018.08.011 ↗
10. Zhang · Angew. Chem., Int. Ed. · 2018 · 57 · 706610.1002/anie.201801984 ↗
11. Li · Biomaterials · 2019 · 194 · 8410.1016/j.biomaterials.2018.12.017 ↗
12. Zhang · ACS Appl. Mater. Interfaces · 2019 · 11 · 3959410.1021/acsami.9b14084 ↗
13. Phua · ACS Nano · 2019 · 13 · 474210.1021/acsnano.9b01087 ↗
14. Liang · ACS Nano · 2020 · 14 · 1356910.1021/acsnano.0c05617 ↗
15. Shi · Theranostics · 2020 · 10 · 1160710.7150/thno.46228 ↗
16. Xu · ACS Nano · 2020 · 14 · 341410.1021/acsnano.9b09426 ↗
17. Liu · ACS Appl. Mater. Interfaces · 2019 · 11 · 4826110.1021/acsami.9b18112 ↗
18. Gao · Theranostics · 2018 · 8 · 387210.7150/thno.27815 ↗
19. Fu · Bioconjugate Chem. · 2014 · 25 · 160210.1021/bc500320j ↗
20. Ray · Nanomedicine · 2017 · 12 · 94110.2217/nnm-2016-0393 ↗
21. Posey · Bioconjugate Chem. · 2018 · 29 · 267910.1021/acs.bioconjchem.8b00363 ↗
22. Lee · Theranostics · 2019 · 9 · 328010.7150/thno.34412 ↗
23. Chang · Nano Lett. · 2017 · 17 · 167810.1021/acs.nanolett.6b04955 ↗
24. Lv · Biomaterials · 2018 · 182 · 16710.1016/j.biomaterials.2018.08.023 ↗
25. Zhang · Nat. Commun. · 2018 · 9 · 137710.1038/s41467-018-03779-8 ↗
26. Lv · Biomaterials · 2019 · 218 · 11935810.1016/j.biomaterials.2019.119358 ↗
27. Li · ACS Nano · 2020 · 14 · 158610.1021/acsnano.9b06689 ↗
28. Rong · Sci. Adv. · 2020 · 6 · eaaz177410.1126/sciadv.aaz1774 ↗