Osteoimmunomodulation by bone implant materials: harnessing physicochemical properties and chemical composition
Source abstract
Abstract
Chronic inflammation at bone defect sites can impede regenerative processes, but local immune responses can be adjusted to promote healing. Regulating the osteoimmune microenvironment, particularly through macrophage polarization, has become a key focus in bone regeneration research. While bone implants are crucial for addressing significant bone defects, they are often recognized by the immune system as foreign, triggering inflammation that leads to bone resorption and implant issues like fibrous encapsulation and aseptic loosening. Developing osteoimmunomodulatory implants offers a promising approach to transforming destructive inflammation into healing processes, enhancing implant integration and bone regeneration. This review explores strategies based on tuning the physicochemical attributes and chemical composition of materials in engineering osteoimmunomodulatory and pro-regenerative bone implants.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Osteoarthritis Treatment and Mechanisms · Protein Hydrolysis and Bioactive Peptides · Mast cells and histamine
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands
Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
Metabolic Diseases Pediatrics Division, University Medical Centre Utrecht, Utrecht, The Netherlands
Regenerative Medicine Centre Utrecht, Utrecht University, Utrecht, The Netherlands
Department of Microbiology, Islamic Azad University, North Tehran Branch, Tehran, Iran
Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, USA
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