journal article·2020

Recent innovations in artificial skin

Zhi Wei Kenny Low, Zibiao Li, Cally Owh, Pei Lin Chee, Enyi Ye, Kai Dan, Siew Yin Chan, David James Young, Xian Jun Loh

Biomaterials Science· Volume 8· Issue 3
Publisher page

Abstract

The skin is a "smart", multifunctional organ that is protective, self-healing and capable of sensing and many forms of artificial skins have been developed with properties and functionalities approximating those of natural skin. Starting from specific commercial products for the treatment of burns, progress in two fields of research has since allowed these remarkable materials to be viable skin replacements for a wide range of dermatological conditions. This review maps out the development of bioengineered skin replacements and synthetic skin substitutes, including electronic skins. The specific behaviors of these skins are highlighted, and the performances of both types of artificial skins are evaluated against this. Moving beyond mere replication, highly advanced artificial skin materials are also identified as potential augmented skins that can be used as flexible electronics for health-care monitoring and other applications.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Neuroscience and Neural Engineering · Nanomaterials and Printing Technologies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Materials Research and Engineering

A*STAR

Singapore 138634

Institute of Flexible Electronics (IFE)

Northwestern Polytechnical University (NPU)

Xi'an

P.R. China

College of Engineering

Information Technology and Environment

Charles Darwin University

Darwin

Australia

Funding

Agency for Science, Technology and Research

References (100+)

Show source-provided references
1. Lillywhite · J. Zool. · 1987 · 211 · 72710.1111/j.1469-7998.1987.tb04483.x ↗
2. Silver · Oryx · 2004 · 38 · 14810.1017/S0030605304000286 ↗
3. Sizeland · J. Agric. Food Chem. · 2013 · 61 · 88710.1021/jf3043067 ↗
4. Bhushan · Beilstein J. Nanotechnol. · 2011 · 2 · 6610.3762/bjnano.2.9 ↗
5. Mann · Antimicrob. Resist. Infect. Control · 2014 · 3 · 2810.1186/2047-2994-3-28 ↗
6. T. Järvilehto and H.Hämäläinen , in Sensory Functions of the Skin of Humans , ed. D. R. Kenshalo , Springer US , Boston, MA , 1979 , pp. 279–297 , 10.1007/978-1-4613-3039-4_1510.1007/978-1-4613-3039-4_15 ↗
7. Baddour · Birth Defects Res., Part C · 2012 · 96 · 110.1002/bdrc.21006 ↗
8. Schulz 3rd · Annu. Rev. Med. · 2000 · 51 · 23110.1146/annurev.med.51.1.231 ↗
9. Brohem · Pigm. Cell Melanoma Res. · 2011 · 24 · 3510.1111/j.1755-148X.2010.00786.x ↗
10. Chortos · Nat. Mater. · 2016 · 15 · 93710.1038/nmat4671 ↗
11. Damluji · Pathobiology · 1979 · 47 · 22610.1159/000162940 ↗
12. Singh · Ann. Plast. Surg. · 2007 · 59 · 10910.1097/01.sap.0000252065.90759.e6 ↗
13. Ruszczak · Dermatol. Surg. · 2000 · 26 · 21910.1046/j.1524-4725.2000.09215.x ↗
14. Wood · Burns · 2006 · 32 · 39510.1016/j.burns.2006.01.008 ↗
15. Cuono · Plast. Reconstr. Surg. · 1987 · 80 · 62610.1097/00006534-198710000-00029 ↗
16. Abbott · Cryobiology · 1970 · 6 · 41610.1016/S0011-2240(70)80099-2 ↗
17. Yannas · J. Biomed. Mater. Res. · 1980 · 14 · 6510.1002/jbm.820140108 ↗
18. Yannas · Science · 1982 · 215 · 17410.1126/science.7031899 ↗
19. Loss · Burns · 2000 · 26 · 64410.1016/S0305-4179(00)00045-0 ↗
20. L. Yildirimer , D.Hobson , Z. Y.Lin , W.Cui and X.Zhao , Tissue Engineering for Artificial Organs , Wiley-VCH Verlag GmbH & Co. KGaA , Weinheim , 2017
21. Pham · Burns · 2007 · 33 · 94610.1016/j.burns.2007.03.020 ↗
22. Corr · Adv. Wound Care · 2013 · 2 · 3710.1089/wound.2011.0321 ↗
23. Maselli · Front. Hum. Neurosci. · 2013 · 7 · 8310.3389/fnhum.2013.00083 ↗
24. Girard · Tissue Eng., Part B · 2017 · 23 · 5910.1089/ten.teb.2016.0195 ↗
25. Weiß-Becker · Scand. J. Plast. Reconstr. Surg. Hand Surg. · 1998 · 32 · 15710.1080/02844319850158778 ↗
26. Nedelec · Burns · 2005 · 31 · 81710.1016/j.burns.2005.06.007 ↗
27. Anderson · Burns · 2011 · 37 · 110110.1016/j.burns.2011.04.002 ↗
28. Proksch · Exp. Dermatol. · 2008 · 17 · 106310.1111/j.1600-0625.2008.00786.x ↗
29. Y.-C. Fung , Biomechanics: Mechanical Properties of Living Tissues , Springer , New York , 199310.1007/978-1-4757-2257-4 ↗
30. Yang · Nat. Commun. · 2015 · 6 · 664910.1038/ncomms7649 ↗
31. W. Montagna and P. F.Parakkal , The Structure & Function of Skin , Academic Press , New York and London , 3rd edn, 1974
32. Rawlings · Dermatol. Ther. · 2004 · 17 · 4310.1111/j.1396-0296.2004.04S1005.x ↗
33. Nemes · Exp. Mol. Med. · 1999 · 31 · 510.1038/emm.1999.2 ↗
34. Williams · Adv. Drug Delivery Rev. · 2004 · 56 · 60310.1016/j.addr.2003.10.025 ↗
35. Bos · Exp. Dermatol. · 2000 · 9 · 16510.1034/j.1600-0625.2000.009003165.x ↗
36. Picard · J. Membr. Sci. · 2008 · 313 · 28410.1016/j.memsci.2008.01.011 ↗
37. Sanchez-Garcia · J. Appl. Polym. Sci. · 2010 · 118 · 18810.1002/app.31986 ↗
38. J. Fenner and R. A. F.Clark , Skin Tissue Engineering and Regenerative Medicine , Academic Press , Boston , 2016
39. Dash · Prog. Polym. Sci. · 2011 · 36 · 98110.1016/j.progpolymsci.2011.02.001 ↗
40. Marambio-Jones · J. Nanopart. Res. · 2010 · 12 · 153110.1007/s11051-010-9900-y ↗
41. Fan · Adv. Funct. Mater. · 2014 · 24 · 393310.1002/adfm.201304202 ↗
42. Matyjaszewski · Nat. Chem. · 2009 · 1 · 27610.1038/nchem.257 ↗
43. Kenawy · Biomacromolecules · 2007 · 8 · 135910.1021/bm061150q ↗
44. Zhao · J. Biomed. Mater. Res., Part B · 2009 · 91 · 47010.1002/jbm.b.31463 ↗
45. Dunne · Clin. Microbiol. Rev. · 2002 · 15 · 15510.1128/CMR.15.2.155-166.2002 ↗
46. Fu · J. Biomed. Mater. Res., Part A · 2006 · 79 · 66510.1002/jbm.a.30819 ↗
47. Li · RSC Adv. · 2016 · 6 · 2894710.1039/C6RA04531F ↗
48. Dhand · ACS Appl. Mater. Interfaces · 2016 · 8 · 3226610.1021/acsami.6b12544 ↗
49. Wu · Prog. Polym. Sci. · 2008 · 33 · 47910.1016/j.progpolymsci.2008.02.001 ↗
50. Brochu · J. Biomed. Mater. Res., Part A · 2011 · 96 · 49210.1002/jbm.a.32987 ↗
51. Cordier · Nature · 2008 · 451 · 97710.1038/nature06669 ↗
52. Nakahata · Nat. Commun. · 2011 · 2 · 51110.1038/ncomms1521 ↗
53. Rule · Adv. Mater. · 2005 · 17 · 20510.1002/adma.200400607 ↗
54. Bleay · Composites, Part A · 2001 · 32 · 176710.1016/S1359-835X(01)00020-3 ↗
55. Toohey · Nat. Mater. · 2007 · 6 · 58110.1038/nmat1934 ↗
56. Iger · J. Fish Biol. · 1990 · 36 · 42110.1111/j.1095-8649.1990.tb05622.x ↗
57. Martin · Science · 1997 · 276 · 7510.1126/science.276.5309.75 ↗
58. Krawczyk · J. Cell Biol. · 1971 · 49 · 24710.1083/jcb.49.2.247 ↗
59. Foulds · Br. J. Dermatol. · 1983 · 109 · 51510.1111/j.1365-2133.1983.tb07673.x ↗
60. Nuccitelli · Wound Repair Regen. · 2011 · 19 · 64510.1111/j.1524-475X.2011.00723.x ↗
61. Lumpkin · Nature · 2007 · 445 · 85810.1038/nature05662 ↗
62. Bean · Nat. Rev. Neurosci. · 2007 · 8 · 45110.1038/nrn2148 ↗
63. D. Kenshalo , The Skin Senses , Charles C Thomas , Springfield , 1968
64. Woo · Nature · 2014 · 509 · 62210.1038/nature13251 ↗
65. Johnson · J. Clin. Neurophysiol. · 2000 · 17 · 53910.1097/00004691-200011000-00002 ↗
66. Millan · Prog. Neurobiol. · 1999 · 57 · 110.1016/S0301-0082(98)00048-3 ↗
67. Dhaka · Annu. Rev. Neurosci. · 2006 · 29 · 13510.1146/annurev.neuro.29.051605.112958 ↗
68. Szolcsányi · Neuropeptides · 2004 · 38 · 37710.1016/j.npep.2004.07.005 ↗
69. Peier · Cell · 2002 · 108 · 70510.1016/S0092-8674(02)00652-9 ↗
70. Athenstaedt · Science · 1982 · 216 · 101810.1126/science.6177041 ↗
71. De Rossi · Adv. Colloid Interface Sci. · 2005 · 116 · 16510.1016/j.cis.2005.05.002 ↗
72. Hammond · Adv. Mater. · 2004 · 16 · 127110.1002/adma.200400760 ↗
73. Zeng · Adv. Mater. · 2014 · 26 · 531010.1002/adma.201400633 ↗
74. Hammock · Adv. Mater. · 2013 · 25 · 599710.1002/adma.201302240 ↗
75. Chan · ACS Appl. Mater. Interfaces · 2016 · 8 · 1007010.1021/acsami.6b01295 ↗
76. Stuart · Nat. Mater. · 2010 · 9 · 10110.1038/nmat2614 ↗
77. Ichihashi · Toxicology · 2003 · 189 · 2110.1016/S0300-483X(03)00150-1 ↗
78. Haltaufderhyde · Photochem. Photobiol. · 2015 · 91 · 11710.1111/php.12354 ↗
79. Anderson · J. Invest. Dermatol. · 1981 · 77 · 1310.1111/1523-1747.ep12479191 ↗
80. Pontén · J. Invest. Dermatol. · 1995 · 105 · 40210.1111/1523-1747.ep12321071 ↗
81. Rittié · Ageing Res. Rev. · 2002 · 1 · 70510.1016/S1568-1637(02)00024-7 ↗
82. Metcalfe · Biomaterials · 2007 · 28 · 510010.1016/j.biomaterials.2007.07.031 ↗
83. Seal · Mater. Sci. Eng., R · 2001 · 34 · 14710.1016/S0927-796X(01)00035-3 ↗
84. Chen · Biomaterials · 2003 · 24 · 116710.1016/S0142-9612(02)00466-0 ↗
85. Shalumon · J. Biomed. Nanotechnol. · 2012 · 8 · 40510.1166/jbn.2012.1395 ↗
86. Zhang · Biomacromolecules · 2005 · 6 · 258310.1021/bm050314k ↗
87. Lowery · Biomaterials · 2010 · 31 · 49110.1016/j.biomaterials.2009.09.072 ↗
88. Kai · ACS Sustainable Chem. Eng. · 2014 · 2 · 10610.1021/sc400340p ↗
89. Asran · Biomacromolecules · 2010 · 11 · 341310.1021/bm100912v ↗
90. Sodian · Tissue Eng. · 2000 · 6 · 18310.1089/107632700320793 ↗
91. Hirt · Macromol. Chem. Phys. · 1996 · 197 · 425310.1002/macp.1996.021971221 ↗
92. Avella · J. Mater. Sci. · 2000 · 35 · 52310.1023/A:1004740522751 ↗
93. Hoque · J. Biomater. Sci., Polym. Ed. · 2005 · 16 · 159510.1163/156856205774576709 ↗
94. Ruszczak · Adv. Drug Delivery Rev. · 2003 · 55 · 159510.1016/j.addr.2003.08.003 ↗
95. Friess · Eur. J. Pharm. Biopharm. · 1998 · 45 · 11310.1016/S0939-6411(98)00017-4 ↗
96. Ma · Biomaterials · 2003 · 24 · 483310.1016/S0142-9612(03)00374-0 ↗
97. Powell · J. Biomed. Mater. Res., Part A · 2008 · 84 · 107810.1002/jbm.a.31498 ↗
98. Wang · Nat. Biotechnol. · 2002 · 20 · 60210.1038/nbt0602-602 ↗
99. Pomerantseva · J. Biomed. Mater. Res., Part A · 2009 · 91 · 103810.1002/jbm.a.32327 ↗
100. Sundback · Biomaterials · 2005 · 26 · 545410.1016/j.biomaterials.2005.02.004 ↗