The research and preparation of a novel nano biodegradable polymer external reinforcement

Abstract The use of current drug-loaded vascular scaffolds is limited in sustained drug release and stability studies in clinical and preclinical trials. We found that poly( l -glutamic acid)-b-poly(propylene oxide)-b-poly( l -glutamic acid) (PLGA-b-PPO-b-PLGA) triblock copolymers can deliver multiple poorly water-soluble drugs (e.g., Paclitaxel) at clinically relevant doses. In this study, we synthesized a new drug-loaded vascular external graft with electrospun nanofibrous scaffolds [poly( l -lactide-co-ɛ-caprolactone) (PLCL):fibrinogen; 2:1 (w/w)] and drug-loaded PLGA-b-PPO-b-PLGA micelles. Cell proliferation and viability assay results showed that beagle smooth muscle cells grew well on the surface of vascular graft-coated micelles at a percentages of 10% (w/w) GPG:PLCL–fibrinogen. This study demonstrates that micelle-coated electrospun PLCL–fibrinogen vascular scaffolds have potential applications in vascular tissue engineering.