Biological properties of a novel β-Ti alloy with a low young’s modulus subjected to cold rolling
Source abstract
Abstract
Abstract The main aim of this study was to investigate the effect of plastic deformation on the biological behaviour of novel Ti-29Nb-13Ta-4.6Zr alloy and to compare it with microcrystalline α titanium, commonly used in medicine. A multiple-stage cold rolling process was applied to improve both the mechanical and functional properties in a TNTZ alloy. A systematic characterization of the microstructure of all tested materials was performed, followed by a correlation with the mechanical properties and phase composition. A cellular response test based on osteosarcoma MG63 osteoblast like cells was carried out in order to analyse the influence of plastic deformation on the biocompatibility of the TNTZ alloy subjected to cold rolling. A detailed surface characterization including inter alia: contact angle and surface free energy, XPS, AES and AFM, was made to define the key factors affecting cellular adhesion to the surface of the deformed samples. The adhered cells were analyzed using confocal and atom force microscopies after 4 days of incubation. Our initial tests indicated that the novel β-Ti alloy subjected to the cold rolling process could be a promising new candidate in the fields of orthopaedics and dentistry implantations.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Titanium Alloys Microstructure and Properties · Orthopaedic implants and arthroplasty · Advanced materials and composites
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (60)
Show source-provided references
1. Engineering biocompatible implant surfaces Part I: materials and surfaces10.1016/j.pmatsci.2012.09.001 ↗
2. Surface modification of titanium, titanium alloys, and related materials for biomedical applications10.1016/j.mser.2004.11.001 ↗
3. Corrosion resistance, mechanical properties, corrosion fatigue strength and cytocompatibility of new Ti alloys without Al and V10.1016/S0142-9612(97)00235-4 ↗
4. Corrosion behavior of biomedical Ti-24Nb-4Zr-8Sn alloy in different simulated body solutions10.1016/j.msec.2013.01.036 ↗
5. Mechanical properties of biocompatible beta-type titanium alloy coated with calcium phosphate invert glass-ceramic layer10.2320/matertrans.46.1564 ↗
6. Significant improvement in cell adhesion and wear resistance of biomedical β-type titanium alloy through ultrasonic nanocrystal surface modification10.1016/j.jallcom.2018.05.088 ↗
7. Peculiar elastic behavior of Ti-Nb-Ta-Zr single crystals10.1016/j.actamat.2008.02.017 ↗
8. Origin of low Young modulus of multicomponent, biomedical Ti alloys - seeking optimal elastic properties through a first principles investigation10.1016/j.jmbbm.2018.08.040 ↗
9. Glide and cross-slip of a-dislocations in Zr and Ti10.1016/j.actamat.2018.05.038 ↗
10. Basal slip of 〈a〉 screw dislocations in hexagonal titanium10.1016/j.scriptamat.2018.11.027 ↗
11. Mechanical biocompatibilities of titanium alloys for biomedical applications10.1016/j.jmbbm.2007.07.001 ↗
12. Influence of nanostructure on titanium corrosion resistance in fluoridated medium10.1080/02670836.2017.1407557 ↗
13. Microstructure and mechanical properties of cold-rolled TiNbTaZr biomedical β titanium alloy10.1016/j.msea.2008.03.003 ↗
14. Effects of cold rolling on microstructure, texture evolution and mechanical properties of Ti-32.5Nb-6.8Zr-2.7Sn-0.3O alloy for biomedical applications10.1016/j.msea.2017.02.045 ↗
15. Effects of annealing on microstructure and mechanical properties of nano-grained titanium produced by combination of asymmetric and symmetric rolling10.1016/j.msea.2012.08.005 ↗
16. Bulk nanostructured titanium fabricated by hydrostatic extrusion10.1002/pssc.200983396 ↗
17. Progress in hydrostatic extrusion of titanium10.1007/s10853-012-7086-7 ↗
18. Enhancement of the corrosion resistance and mechanical properties of nanocrystalline titanium by low-temperature annealing10.1016/j.corsci.2018.11.016 ↗
19. Manufacturing of nanostructured titanium Grade2 using caliber rolling10.1016/j.msea.2018.10.011 ↗
20. Comparative study of compressive and fatigue strength of dental implants made of nanocrystalline Ti Hard and microcrystalline Ti G4, Fatigue Fract
21. Nanostructuring of a titanium material by high-pressure torsion improves pre-osteoblast attachment10.1002/adma.200602276 ↗
22. In vitro biocompatibility of equal channel angular processed (ECAP) titanium10.1088/1748-6041/2/3/S06 ↗
23. Understanding the impact of grain structure in austenitic stainless steel from a nanograined regime to a coarse-grained regime on osteoblast functions using a novel metal deformation-annealing sequence10.1016/j.actbio.2012.12.003 ↗
24. Biological activity of nanostructured metallic materials for biomedical applications
25. In vitro fibroblast response to ultra fine grained titanium produced by a severe plastic deformation process10.1007/s10856-007-3204-5 ↗
26. Accelerated stem cell attachment to ultrafine grained titanium10.1016/j.actbio.2010.09.033 ↗
27. Relationship between surface properties (roughness, wettability) of titanium and titanium alloys and cell behaviour10.1016/S0928-4931(03)00033-X ↗
28. Designing implant surface topography for improved biocompatibility10.1586/erd.12.82 ↗
29. Heterogeneous structure and mechanical hardness of biomedical β-type Ti-29Nb-13Ta-4.6Zr subjected to high-pressure torsion10.1016/j.jmbbm.2012.02.022 ↗
30. Developing biomedical nano-grained β-type titanium alloys using high pressure torsion for improved cell adherence10.1039/C5RA23454A ↗
31. Image based analysis of complex microstructures of engineering materials10.2478/v10006-008-0003-1 ↗
32. Stereology of nano-materials10.5566/ias.v29.p1-12 ↗
33. Internal nanocrystalline structure and stiffness alterations of electrospun polycaprolactone-based mats after six months of in vitro degradation. An atomic force microscopy assay10.1016/j.jmbbm.2019.103437 ↗
34. Multi-scale characterization and biological evaluation of composite surface layers produced under glow discharge conditions on NiTi shape memory alloy for potential cardiological application10.1016/j.micron.2018.07.009 ↗
35. Corrosion behavior of Ti-29Nb-13Ta-4.6Zr and commercially pure Ti under simulated inflammatory conditions – comparative effect of grain refinement and non-toxic β phase stabilizers10.1016/j.electacta.2019.04.138 ↗
36. Biological behavior of titanium processed by severe plastic deformation10.1016/j.apsusc.2018.04.120 ↗
37. AFM assessing of nanomechanical fingerprints for cancer early diagnosis and classification: from single cell to tissue level10.1039/C8NR06146G ↗
38. The influence of carbon-encapsulated iron nanoparticles on elastic modulus of living human mesenchymal stem cells examined by atomic force microscopy10.1016/j.micron.2018.02.006 ↗
39. Microstructural evolution of precipitation-hardened β-type titanium alloy through high-pressure torsion10.1016/j.actamat.2014.07.041 ↗
40. New beta-type Ti-Fe-Sn-Nb alloys with superior mechanical strength10.1016/j.msea.2017.08.060 ↗
41. Microstrain and grain-size analysis from diffraction peak width and graphical derivation of high-pressure thermomechanics10.1107/S0021889808031762 ↗
42. Dislocations, grain size and planar faults in nanostructured copper determined by high resolution X-ray diffraction and a new procedure of peak profile analysis10.1016/S1359-6454(98)00001-9 ↗
43. Microstructure evolution during cold rolling in a nanocrystalline Ni-Fe alloy determined by synchrotron X-ray diffraction10.1016/j.actamat.2009.07.002 ↗
44. Microstructural parameters from X-ray diffraction peak broadening10.1016/j.scriptamat.2004.05.007 ↗
45. Interplay between grain structure and protein adsorption on functional response of osteoblasts: Ultrafine-grained versus coarse-grained substrates10.1002/jbm.a.34105 ↗
46. The effect of grain size on the surface properties of titanium grade 2 after different treatments10.1016/j.surfcoat.2017.12.005 ↗
47. Corrosion resistance of nanostructured titanium10.1016/j.bioeng.2007.08.007 ↗
48. The application of x-ray photo-electron spectroscopy to a study of interfacial composition in corrosion-induced paint de-adhesion10.1016/0010-938X(81)90033-0 ↗
49. Evidence of antibacterial activity on titanium surfaces through nanotextures10.1016/j.apsusc.2014.04.155 ↗
50. An X-ray photoelectron spectroscopy sputter profile study of the native air-formed oxide film on titanium10.1016/S0169-4332(98)00927-1 ↗
51. Surface hydroxyl groups direct cellular response on amorphous and anatase TiO2 nanodots10.1016/j.colsurfb.2014.08.030 ↗
52. Surface hydroxyl groups regulate the osteogenic differentiation of mesenchymal stem cells on titanium and tantalum metals10.1039/C7TB00111H ↗
53. Composition and processing effects on the electrochemical characteristics of biomedical titanium alloys10.1016/j.corsci.2014.02.017 ↗
54. Corrosion and passivity of Ti-13% Nb-13% Zr in comparison to other biomedical implant alloys10.5006/1.3290281 ↗
55. Recent trends in surface metrology10.1016/j.wear.2010.06.001 ↗
56. Scaffold stiffness influences cell behavior: opportunities for skeletal tissue engineering10.2174/1874325000802010103 ↗
57. The role of matrix stiffness in regulating cell behavior10.1002/hep.22193 ↗
58. Accelerated growth of preosteoblastic cells on ultrafine grained titanium10.1002/jbm.a.32174 ↗
59. Enhanced osteoblast response to an equal channel angular pressing-processed pure titanium substrate with microrough surface topography10.1016/j.actbio.2009.04.038 ↗
60. Actin filament mechanics and structure in crowded environments10.1021/acs.jpcb.8b12320 ↗