Synthesis of biomedical composite scaffolds by laser sintering: Mechanical properties and in vitro bioactivity evaluation
Source abstract
Abstract
Abstract In this study, biomedical composite materials were employed to fabricate bone scaffolds using a self-developed rapid prototyping (RP) apparatus. The slurry formed by combining hydroxyapatite (HA), silica sol, and sodium tripolyphosphate (STPP) was heated by a CO 2 laser. Under appropriate processing parameters, a biocomposite green body was subsequently fabricated. Its mechanical properties, including surface roughness, bending and compression strengths, volume shrinkage rate, and surface microstructure, were analyzed after heat treatment to 1200 °C, 1300 °C, and 1400 °C. The results showed that after heating the specimen to 1200 °C, its compression and bending strengths increased significantly to 43.26 MPa and 1.28 MPa, respectively; the surface roughness was 12 μm; and surface pores were of size 5–25 μm. Furthermore, the results of WST-1 and LDH assay indicate that the biocomposites showed no cytotoxicity on 3T3 fibroblast. An optical density (OD) of 1.1 was also achieved, and the specimen was suitable for the adhesion and growth of osteoblast-like cells (MG63). Therefore, the biocomposite bone scaffolds fabricated in this study have potential to be bone implants for developing hard tissue.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental materials and restorations · Additive Manufacturing and 3D Printing Technologies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (32)
Show source-provided references
1. Fabrication of pre-determined shape of bone segment with collagen-hydroxyapatite scaffold and autogenous platelet-rich plasma10.1007/s10856-008-3507-1 ↗
2. Application of human amniotic mesenchymal cells as an allogeneic transplantation cell source in bone regenerative therapy10.1016/j.msec.2012.07.021 ↗
3. A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics10.1016/j.biomaterials.2011.01.004 ↗
4. A double-chamber rotating bioreactor for the development of tissue-engineered hollow organs: from concept to clinical trial10.1016/j.biomaterials.2009.07.018 ↗
5. Cartilage regeneration in SCID mice using a highly organized three-dimensional alginate scaffold10.1016/j.biomaterials.2011.09.042 ↗
6. Application study of rapid prototyping manufacturing in media
7. Latest advance of laser direction manufacturing of metallic parts10.3788/CJL20103701.0018 ↗
8. Effects of silica and zinc oxide doping on mechanical and biological properties of 3D printed tricalcium phosphate tissue engineering scaffolds10.1016/j.dental.2011.09.010 ↗
9. Resorbable dicalcium phosphate bone substitutes prepared by 3D powder printing10.1002/adfm.200700019 ↗
10. 3D-printing of highly uniform CaSiO3 ceramic scaffolds: preparation, characterization and in vivo osteogenesis10.1039/c2jm30566f ↗
11. Differences between in vitro viability and differentiation and in vivo bone-forming efficacy of human mesenchymal stem cells cultured on PCL-TCP scaffolds10.1016/j.biomaterials.2010.07.001 ↗
12. Fabrication of 13-93 bioactive glass scaffolds for bone tissue engineering using indirect selective laser sintering10.1088/1758-5082/3/2/025004 ↗
13. Development of a 95/5 poly(l-lactide-co-glycolide)/hydroxylapatite and β-tricalcium phosphate scaffold as bone replacement material via selective laser sintering10.1002/jbm.b.30839 ↗
14. S Calcium orthophosphate F bioceramics10.4028/www.scientific.net/JBBTE.5.57 ↗
15. A new slurry-based shaping process for fabricating ceramic green part by selective laser scanning the gelled layer10.1016/j.jeurceramsoc.2012.04.014 ↗
16. Consolidation phenomena in laser and powder-bed based layered manufacturing10.1016/j.cirp.2007.10.004 ↗
17. Fabrication of inner complex ceramic parts by selective laser gelling10.1016/j.jeurceramsoc.2010.08.001 ↗
18. Selective laser sintering of a hydroxyapatite silica scaffold on cultured MG63 osteoblast in vitro10.1007/s12541-012-0056-9 ↗
19. The effect of microsized roughness in nano/microsized hierarchical surfaces replicated from a lotus leaf on the activities of osteoblast-like cells (MG63)10.1039/c2jm16765d ↗
20. Sol–gel-derived glass scaffold with high pore interconnectivity and enhanced bioactivity10.1557/jmr.2009.0440 ↗
21. Glass reinforced hydroxyapatite for hard tissue surgery-part 1: mechanical properties10.1016/S0142-9612(01)00025-4 ↗
22. Synthesis and sintered properties evaluation of calcium phosphate ceramics10.1016/j.msec.2006.06.021 ↗
23. The effect of sintering temperature on the properties of hydroxyapatite10.1016/S0272-8842(99)00046-2 ↗
24. Effect of surface topography and chemistry on adhesion, orientation and growth of fibroblasts on nickel-titanium substrates10.1016/S0928-4931(02)00097-8 ↗
25. In vitro effects on MG63 osteoblast-like cells following contact with two roughness-differing fluorohydroxyapatite-coated titanium alloys10.1016/S0142-9612(02)00098-4 ↗
26. Rat bone marrow cell response to titanium and titanium alloy with different surface roughness10.1034/j.1600-0501.2003.140106.x ↗
27. Genetic design of bioactive glass10.1016/j.jeurceramsoc.2008.08.002 ↗
28. Study of hydroxyapatite nano composites with photoluminescence properties
29. Synthesis of bioceramic scaffolds for bone tissue engineering by rapid prototyping technique10.1007/s10971-012-2905-5 ↗
30. Bioactivity and mineralization of hydroxyapatite with bioglass as sintering aid and bioceramics with Na3Ca6(PO4)5 and Ca5(PO4)2SiO4 in a silicate matrix10.1016/j.msec.2009.10.011 ↗
31. Design and production of sintered β-tricalcium phosphate 3D scaffolds for bone tissue regeneration10.1016/j.msec.2012.04.010 ↗
32. Fabrication of three-dimensional polycaprolactone/hydroxyapatite tissue scaffolds and osteoblast-scaffold interactions in vitro10.1016/j.biomaterials.2007.08.018 ↗